Characterization and antigenicity of the promising vaccine candidate Plasmodium vivax 34 kDa rhoptry antigen (Pv34)

Alvaro Mongui, Diana I. Angel, Gina Gallego, Claudia Reyes, Paola Martinez, Felipe Guhl, Manuel A. Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

14 Citas (Scopus)

Resumen

This study describes the identification of the Plasmodium vivax rhoptry antigen Pv34 whose sequence was obtained based on homology comparison with the Plasmodium falciparum Pf34. The pv34 gene product was characterized by molecular biology and immunological techniques. Additionally, association of Pv34 to detergent-resistant microdomains (DRMs), expression in late blood-stage parasites and recognition of recombinant Pv34 (rPv34) by sera from P. vivax-infected Aotus monkeys and patients was assessed. Lymphoproliferation and cytokine secretion was also evaluated in individuals living in malaria endemic areas. Altogether, the data support carrying out further studies to assess the immunogenicity and protection-inducing ability of rPv34 as component of a multi-antigenic, multi-stage vaccine against vivax malaria. © 2009 Elsevier Ltd. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)415-421
Número de páginas7
PublicaciónVaccine
DOI
EstadoPublished - dic 11 2009

Huella dactilar

Plasmodium vivax
malaria
vaccines
Vivax Malaria
Immunologic Techniques
antigens
Aotus (Cebidae)
Antigens
Plasmodium falciparum
immunologic techniques
blood serum
detergents
Detergents
molecular biology
Malaria
Haplorhini
monkeys
Molecular Biology
Parasites
cytokines

Citar esto

Mongui, Alvaro ; Angel, Diana I. ; Gallego, Gina ; Reyes, Claudia ; Martinez, Paola ; Guhl, Felipe ; Patarroyo, Manuel A. / Characterization and antigenicity of the promising vaccine candidate Plasmodium vivax 34 kDa rhoptry antigen (Pv34). En: Vaccine. 2009 ; pp. 415-421.
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title = "Characterization and antigenicity of the promising vaccine candidate Plasmodium vivax 34 kDa rhoptry antigen (Pv34)",
abstract = "This study describes the identification of the Plasmodium vivax rhoptry antigen Pv34 whose sequence was obtained based on homology comparison with the Plasmodium falciparum Pf34. The pv34 gene product was characterized by molecular biology and immunological techniques. Additionally, association of Pv34 to detergent-resistant microdomains (DRMs), expression in late blood-stage parasites and recognition of recombinant Pv34 (rPv34) by sera from P. vivax-infected Aotus monkeys and patients was assessed. Lymphoproliferation and cytokine secretion was also evaluated in individuals living in malaria endemic areas. Altogether, the data support carrying out further studies to assess the immunogenicity and protection-inducing ability of rPv34 as component of a multi-antigenic, multi-stage vaccine against vivax malaria. {\circledC} 2009 Elsevier Ltd. All rights reserved.",
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Characterization and antigenicity of the promising vaccine candidate Plasmodium vivax 34 kDa rhoptry antigen (Pv34). / Mongui, Alvaro; Angel, Diana I.; Gallego, Gina; Reyes, Claudia; Martinez, Paola; Guhl, Felipe; Patarroyo, Manuel A.

En: Vaccine, 11.12.2009, p. 415-421.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Characterization and antigenicity of the promising vaccine candidate Plasmodium vivax 34 kDa rhoptry antigen (Pv34)

AU - Mongui, Alvaro

AU - Angel, Diana I.

AU - Gallego, Gina

AU - Reyes, Claudia

AU - Martinez, Paola

AU - Guhl, Felipe

AU - Patarroyo, Manuel A.

PY - 2009/12/11

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N2 - This study describes the identification of the Plasmodium vivax rhoptry antigen Pv34 whose sequence was obtained based on homology comparison with the Plasmodium falciparum Pf34. The pv34 gene product was characterized by molecular biology and immunological techniques. Additionally, association of Pv34 to detergent-resistant microdomains (DRMs), expression in late blood-stage parasites and recognition of recombinant Pv34 (rPv34) by sera from P. vivax-infected Aotus monkeys and patients was assessed. Lymphoproliferation and cytokine secretion was also evaluated in individuals living in malaria endemic areas. Altogether, the data support carrying out further studies to assess the immunogenicity and protection-inducing ability of rPv34 as component of a multi-antigenic, multi-stage vaccine against vivax malaria. © 2009 Elsevier Ltd. All rights reserved.

AB - This study describes the identification of the Plasmodium vivax rhoptry antigen Pv34 whose sequence was obtained based on homology comparison with the Plasmodium falciparum Pf34. The pv34 gene product was characterized by molecular biology and immunological techniques. Additionally, association of Pv34 to detergent-resistant microdomains (DRMs), expression in late blood-stage parasites and recognition of recombinant Pv34 (rPv34) by sera from P. vivax-infected Aotus monkeys and patients was assessed. Lymphoproliferation and cytokine secretion was also evaluated in individuals living in malaria endemic areas. Altogether, the data support carrying out further studies to assess the immunogenicity and protection-inducing ability of rPv34 as component of a multi-antigenic, multi-stage vaccine against vivax malaria. © 2009 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.vaccine.2009.10.034

DO - 10.1016/j.vaccine.2009.10.034

M3 - Article

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EP - 421

JO - Vaccine

JF - Vaccine

SN - 0264-410X

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