Characterisation of the Plasmodium vivax Pv38 antigen

Alvaro Mongui, Diana I. Angel, Catalina Guzman, Magnolia Vanegas, Manuel A. Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

20 Citas (Scopus)

Resumen

This study describes the identification and characterisation of Pv38, based on the available genomic sequence of Plasmodium vivax and previous studies done with its Plasmodium falciparum homologue: Pf38. Pv38 is a 355 amino acid long peptide encoded by a single exon gene, for which orthologous genes have been identified in other Plasmodium species by bioinformatic approaches. As for Pf38, Pv38 was found to contain a s48/45 domain which is usually found in proteins displayed on gametocytes surface. The association of Pv38 with detergent-resistant membranes (DRMs), its expression in mature blood stages of the parasite (mainly schizonts) and the detection of its recombinant protein by sera from Aotus monkeys previously exposed to the parasite, were here assessed to further characterise this new antigen. © 2008 Elsevier Inc. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)326-330
Número de páginas5
PublicaciónBiochemical and Biophysical Research Communications
DOI
EstadoPublished - nov 14 2008

Huella dactilar

Plasmodium vivax
Parasites
Genes
Schizonts
Antigens
Plasmodium
Plasmodium falciparum
Bioinformatics
Computational Biology
Recombinant Proteins
Detergents
Haplorhini
Exons
Blood
Membranes
Amino Acids
Peptides
Serum
Proteins

Citar esto

Mongui, Alvaro ; Angel, Diana I. ; Guzman, Catalina ; Vanegas, Magnolia ; Patarroyo, Manuel A. / Characterisation of the Plasmodium vivax Pv38 antigen. En: Biochemical and Biophysical Research Communications. 2008 ; pp. 326-330.
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Characterisation of the Plasmodium vivax Pv38 antigen. / Mongui, Alvaro; Angel, Diana I.; Guzman, Catalina; Vanegas, Magnolia; Patarroyo, Manuel A.

En: Biochemical and Biophysical Research Communications, 14.11.2008, p. 326-330.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Characterisation of the Plasmodium vivax Pv38 antigen

AU - Mongui, Alvaro

AU - Angel, Diana I.

AU - Guzman, Catalina

AU - Vanegas, Magnolia

AU - Patarroyo, Manuel A.

PY - 2008/11/14

Y1 - 2008/11/14

N2 - This study describes the identification and characterisation of Pv38, based on the available genomic sequence of Plasmodium vivax and previous studies done with its Plasmodium falciparum homologue: Pf38. Pv38 is a 355 amino acid long peptide encoded by a single exon gene, for which orthologous genes have been identified in other Plasmodium species by bioinformatic approaches. As for Pf38, Pv38 was found to contain a s48/45 domain which is usually found in proteins displayed on gametocytes surface. The association of Pv38 with detergent-resistant membranes (DRMs), its expression in mature blood stages of the parasite (mainly schizonts) and the detection of its recombinant protein by sera from Aotus monkeys previously exposed to the parasite, were here assessed to further characterise this new antigen. © 2008 Elsevier Inc. All rights reserved.

AB - This study describes the identification and characterisation of Pv38, based on the available genomic sequence of Plasmodium vivax and previous studies done with its Plasmodium falciparum homologue: Pf38. Pv38 is a 355 amino acid long peptide encoded by a single exon gene, for which orthologous genes have been identified in other Plasmodium species by bioinformatic approaches. As for Pf38, Pv38 was found to contain a s48/45 domain which is usually found in proteins displayed on gametocytes surface. The association of Pv38 with detergent-resistant membranes (DRMs), its expression in mature blood stages of the parasite (mainly schizonts) and the detection of its recombinant protein by sera from Aotus monkeys previously exposed to the parasite, were here assessed to further characterise this new antigen. © 2008 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.bbrc.2008.08.163

DO - 10.1016/j.bbrc.2008.08.163

M3 - Article

SP - 326

EP - 330

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

ER -