Characterisation and comparative analysis of MHC-DPA1 exon 2 in the owl monkey (Aotus nancymaae)

Carlos F. Suárez M.; Manuel A. Patarroyo; Manuel E. Patarroyo

doi:10.1016/j.gene.2010.09.006

Characterisation and comparative analysis of MHC-DPA1 exon 2 in the owl monkey (Aotus nancymaae)

Carlos F. Suárez M.
, Manuel A. Patarroyo
, Manuel E. Patarroyo

Universidad del Rosario

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

6 Citas (Scopus)

Resumen

The Aotus nancymaae (owl monkey) is an important animal model in biomedical research, particularly for the preclinical evaluation of vaccine candidates against Plasmodium falciparum and Plasmodium vivax, which require a precisely typed major histocompatibility complex. The exon 2 from A. nancymaae MHC-DPA1 gene was characterised in order to infer its allelic diversity and evolutionary history. Aona-DPA1 shows no polymorphism and is related to other primate DPA alleles (including Catarrhini and Platyrrhini), constituting an ancient trans-specific and strongly supported lineage with different variability and selective patterns when compared to other primate-MHC-DPA1 lineages. A. nancymaae monkeys have thus a smaller MHC-DP polymorphism than MHC-DQ or MHC-DR.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	37-45
Número de páginas	9
Publicación	Gene
Volumen	470
N.º	1-2
DOI	https://doi.org/10.1016/j.gene.2010.09.006
Estado	Publicada - ene. 1 2011

ODS de las Naciones Unidas

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ODS 3: Salud y bienestar

Áreas temáticas de ASJC Scopus

Genética

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10.1016/j.gene.2010.09.006

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@article{1bf5f1f4a33542979d74b86a094cec86,

title = "Characterisation and comparative analysis of MHC-DPA1 exon 2 in the owl monkey (Aotus nancymaae)",

abstract = "The Aotus nancymaae (owl monkey) is an important animal model in biomedical research, particularly for the preclinical evaluation of vaccine candidates against Plasmodium falciparum and Plasmodium vivax, which require a precisely typed major histocompatibility complex. The exon 2 from A. nancymaae MHC-DPA1 gene was characterised in order to infer its allelic diversity and evolutionary history. Aona-DPA1 shows no polymorphism and is related to other primate DPA alleles (including Catarrhini and Platyrrhini), constituting an ancient trans-specific and strongly supported lineage with different variability and selective patterns when compared to other primate-MHC-DPA1 lineages. A. nancymaae monkeys have thus a smaller MHC-DP polymorphism than MHC-DQ or MHC-DR.",

author = "\{Su{\'a}rez M.\}, \{Carlos F.\} and Patarroyo, \{Manuel A.\} and Patarroyo, \{Manuel E.\}",

note = "Funding Information: This work was funded by COLCIENCIAS , contract RC-140-2009 . We would like to thank Monica Estupi{\~n}an for laboratory technical support in the obtaining of sequences and Gisselle Rivera for helping in the translation of this manuscript. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.",

year = "2011",

month = jan,

day = "1",

doi = "10.1016/j.gene.2010.09.006",

language = "English (US)",

volume = "470",

pages = "37--45",

journal = "Gene",

issn = "0378-1119",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Characterisation and comparative analysis of MHC-DPA1 exon 2 in the owl monkey (Aotus nancymaae)

AU - Suárez M., Carlos F.

AU - Patarroyo, Manuel A.

AU - Patarroyo, Manuel E.

N1 - Funding Information: This work was funded by COLCIENCIAS , contract RC-140-2009 . We would like to thank Monica Estupiñan for laboratory technical support in the obtaining of sequences and Gisselle Rivera for helping in the translation of this manuscript. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.

PY - 2011/1/1

Y1 - 2011/1/1

N2 - The Aotus nancymaae (owl monkey) is an important animal model in biomedical research, particularly for the preclinical evaluation of vaccine candidates against Plasmodium falciparum and Plasmodium vivax, which require a precisely typed major histocompatibility complex. The exon 2 from A. nancymaae MHC-DPA1 gene was characterised in order to infer its allelic diversity and evolutionary history. Aona-DPA1 shows no polymorphism and is related to other primate DPA alleles (including Catarrhini and Platyrrhini), constituting an ancient trans-specific and strongly supported lineage with different variability and selective patterns when compared to other primate-MHC-DPA1 lineages. A. nancymaae monkeys have thus a smaller MHC-DP polymorphism than MHC-DQ or MHC-DR.

AB - The Aotus nancymaae (owl monkey) is an important animal model in biomedical research, particularly for the preclinical evaluation of vaccine candidates against Plasmodium falciparum and Plasmodium vivax, which require a precisely typed major histocompatibility complex. The exon 2 from A. nancymaae MHC-DPA1 gene was characterised in order to infer its allelic diversity and evolutionary history. Aona-DPA1 shows no polymorphism and is related to other primate DPA alleles (including Catarrhini and Platyrrhini), constituting an ancient trans-specific and strongly supported lineage with different variability and selective patterns when compared to other primate-MHC-DPA1 lineages. A. nancymaae monkeys have thus a smaller MHC-DP polymorphism than MHC-DQ or MHC-DR.

UR - https://www.scopus.com/pages/publications/78349310115

UR - https://www.scopus.com/pages/publications/78349310115#tab=citedBy

U2 - 10.1016/j.gene.2010.09.006

DO - 10.1016/j.gene.2010.09.006

M3 - Research Article

C2 - 20884341

AN - SCOPUS:78349310115

SN - 0378-1119

VL - 470

SP - 37

EP - 45

JO - Gene

JF - Gene

IS - 1-2

ER -

Characterisation and comparative analysis of MHC-DPA1 exon 2 in the owl monkey (Aotus nancymaae)

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