TY - JOUR
T1 - Characterisation and comparative analysis of MHC-DPA1 exon 2 in the owl monkey (Aotus nancymaae)
AU - Suárez M., Carlos F.
AU - Patarroyo, Manuel A.
AU - Patarroyo, Manuel E.
N1 - Funding Information:
This work was funded by COLCIENCIAS , contract RC-140-2009 . We would like to thank Monica Estupiñan for laboratory technical support in the obtaining of sequences and Gisselle Rivera for helping in the translation of this manuscript.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - The Aotus nancymaae (owl monkey) is an important animal model in biomedical research, particularly for the preclinical evaluation of vaccine candidates against Plasmodium falciparum and Plasmodium vivax, which require a precisely typed major histocompatibility complex. The exon 2 from A. nancymaae MHC-DPA1 gene was characterised in order to infer its allelic diversity and evolutionary history. Aona-DPA1 shows no polymorphism and is related to other primate DPA alleles (including Catarrhini and Platyrrhini), constituting an ancient trans-specific and strongly supported lineage with different variability and selective patterns when compared to other primate-MHC-DPA1 lineages. A. nancymaae monkeys have thus a smaller MHC-DP polymorphism than MHC-DQ or MHC-DR.
AB - The Aotus nancymaae (owl monkey) is an important animal model in biomedical research, particularly for the preclinical evaluation of vaccine candidates against Plasmodium falciparum and Plasmodium vivax, which require a precisely typed major histocompatibility complex. The exon 2 from A. nancymaae MHC-DPA1 gene was characterised in order to infer its allelic diversity and evolutionary history. Aona-DPA1 shows no polymorphism and is related to other primate DPA alleles (including Catarrhini and Platyrrhini), constituting an ancient trans-specific and strongly supported lineage with different variability and selective patterns when compared to other primate-MHC-DPA1 lineages. A. nancymaae monkeys have thus a smaller MHC-DP polymorphism than MHC-DQ or MHC-DR.
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U2 - 10.1016/j.gene.2010.09.006
DO - 10.1016/j.gene.2010.09.006
M3 - Article
C2 - 20884341
AN - SCOPUS:78349310115
SN - 0378-1119
VL - 470
SP - 37
EP - 45
JO - Gene
JF - Gene
IS - 1-2
ER -
