Changes in selenium levels in epilepsy

Ángela María Gutiérrez-Álvarez, C. B. Moreno, R. E. González-Reyes

Resultado de la investigación: Contribución a RevistaRevisión Literaria

2 Citas (Scopus)

Resumen

Introduction. It has been suggested that antiepileptic drug therapies deplete total body selenium stores and failure to give appropriate selenium supplementation, especially to patients receiving valproic acid during pregnancy may increase the risk of neural tube defects or other free radical mediated damage. Selenium is essential for the synthesis of selenoproteins, including glutathione peroxidase. Aims. To review the present state of knowledge about selenium behaviour in people with epilepsy taking antiepileptic drugs and to develop guidelines for the appropriate use of selenium supplements. Development. Databases such as Medline, Embase, Scisearch and Lilacs were consulted to have access to literature. A search in said databases was performed in order to find articles published from January 1966 to August 2004. All articles published in English and Spanish were considered. A manual review of the references present in each produced article was done in order to identify the articles that the electronic search may have not found itself. The title and abstract of the potential articles were analyzed before asking for the complete article. However, articles which seemed ambiguous were completely analyzed later to establish their relevance. Conclusions. There is insufficient evidence to fully evaluate the effect of selenium supplementation. The possible beneficial effects on pregnancy need to be evaluated in further studies. © 2005, Revista de Neurología.
Idioma originalEnglish (US)
Páginas (desde-hasta)111-116
Número de páginas6
PublicaciónRevista de Neurologia
EstadoPublished - ene 16 2005

Huella dactilar

Selenium
Epilepsy
Anticonvulsants
Databases
Selenoproteins
Pregnancy
Neural Tube Defects
Valproic Acid
Glutathione Peroxidase
Free Radicals
Guidelines
Drug Therapy

Citar esto

Gutiérrez-Álvarez, Á. M., Moreno, C. B., & González-Reyes, R. E. (2005). Changes in selenium levels in epilepsy. Revista de Neurologia, 111-116.
Gutiérrez-Álvarez, Ángela María ; Moreno, C. B. ; González-Reyes, R. E. / Changes in selenium levels in epilepsy. En: Revista de Neurologia. 2005 ; pp. 111-116.
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abstract = "Introduction. It has been suggested that antiepileptic drug therapies deplete total body selenium stores and failure to give appropriate selenium supplementation, especially to patients receiving valproic acid during pregnancy may increase the risk of neural tube defects or other free radical mediated damage. Selenium is essential for the synthesis of selenoproteins, including glutathione peroxidase. Aims. To review the present state of knowledge about selenium behaviour in people with epilepsy taking antiepileptic drugs and to develop guidelines for the appropriate use of selenium supplements. Development. Databases such as Medline, Embase, Scisearch and Lilacs were consulted to have access to literature. A search in said databases was performed in order to find articles published from January 1966 to August 2004. All articles published in English and Spanish were considered. A manual review of the references present in each produced article was done in order to identify the articles that the electronic search may have not found itself. The title and abstract of the potential articles were analyzed before asking for the complete article. However, articles which seemed ambiguous were completely analyzed later to establish their relevance. Conclusions. There is insufficient evidence to fully evaluate the effect of selenium supplementation. The possible beneficial effects on pregnancy need to be evaluated in further studies. {\circledC} 2005, Revista de Neurolog{\'i}a.",
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Gutiérrez-Álvarez, ÁM, Moreno, CB & González-Reyes, RE 2005, 'Changes in selenium levels in epilepsy', Revista de Neurologia, pp. 111-116.

Changes in selenium levels in epilepsy. / Gutiérrez-Álvarez, Ángela María; Moreno, C. B.; González-Reyes, R. E.

En: Revista de Neurologia, 16.01.2005, p. 111-116.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

TY - JOUR

T1 - Changes in selenium levels in epilepsy

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AU - Moreno, C. B.

AU - González-Reyes, R. E.

PY - 2005/1/16

Y1 - 2005/1/16

N2 - Introduction. It has been suggested that antiepileptic drug therapies deplete total body selenium stores and failure to give appropriate selenium supplementation, especially to patients receiving valproic acid during pregnancy may increase the risk of neural tube defects or other free radical mediated damage. Selenium is essential for the synthesis of selenoproteins, including glutathione peroxidase. Aims. To review the present state of knowledge about selenium behaviour in people with epilepsy taking antiepileptic drugs and to develop guidelines for the appropriate use of selenium supplements. Development. Databases such as Medline, Embase, Scisearch and Lilacs were consulted to have access to literature. A search in said databases was performed in order to find articles published from January 1966 to August 2004. All articles published in English and Spanish were considered. A manual review of the references present in each produced article was done in order to identify the articles that the electronic search may have not found itself. The title and abstract of the potential articles were analyzed before asking for the complete article. However, articles which seemed ambiguous were completely analyzed later to establish their relevance. Conclusions. There is insufficient evidence to fully evaluate the effect of selenium supplementation. The possible beneficial effects on pregnancy need to be evaluated in further studies. © 2005, Revista de Neurología.

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M3 - Literature review

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Gutiérrez-Álvarez ÁM, Moreno CB, González-Reyes RE. Changes in selenium levels in epilepsy. Revista de Neurologia. 2005 ene 16;111-116.