TY - JOUR
T1 - Changes in oxygenation levels precede changes in amplitude of the EEG in premature infants
AU - Caicedo, Alexander
AU - Thewissen, Liesbeth
AU - Smits, Anne
AU - Naulaers, Gunnar
AU - Allegaert, Karel
AU - Van Huffel, Sabine
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2016.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016
Y1 - 2016
N2 - Brain function is supported by an appropriate balance between the metabolic demand and the supply of nutrients and oxygen. However, the physiological principles behind the regulation of brain metabolism and demand in premature infants are unknown. Some studies found that changes in hemodynamic variables in this population precede changes in EEG activity; however, these studies only used descriptive statistics. This paper describes the relationship between changes in cerebral oxygenation, assessed by means of near-infrared spectroscopy (NIRS), and changes in EEG, using mathematical methods taken from information dynamics. In a cohort of 35 neonates subjected to sedation by propofol, we quantified the direction of information transfer between brain oxygenation and EEG. The results obtained indicate that, as reported in other studies, changes in NIRS are likely to precede changes in EEG activity.
AB - Brain function is supported by an appropriate balance between the metabolic demand and the supply of nutrients and oxygen. However, the physiological principles behind the regulation of brain metabolism and demand in premature infants are unknown. Some studies found that changes in hemodynamic variables in this population precede changes in EEG activity; however, these studies only used descriptive statistics. This paper describes the relationship between changes in cerebral oxygenation, assessed by means of near-infrared spectroscopy (NIRS), and changes in EEG, using mathematical methods taken from information dynamics. In a cohort of 35 neonates subjected to sedation by propofol, we quantified the direction of information transfer between brain oxygenation and EEG. The results obtained indicate that, as reported in other studies, changes in NIRS are likely to precede changes in EEG activity.
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U2 - 10.1007/978-3-319-38810-6_19
DO - 10.1007/978-3-319-38810-6_19
M3 - Article
C2 - 27526136
AN - SCOPUS:84984861362
SN - 0065-2598
VL - 923
SP - 143
EP - 149
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
T2 - 43rd Annual Meeting of the International Society on Oxygen Transport to Tissue, ISOTT 2015
Y2 - 11 July 2015 through 16 July 2015
ER -