Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis

Oscar Danilo Ortega-Hernandez, Ricardo Pineda-Tamayo, Aryce L. Pardo, Adriana Rojas-Villarraga, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaArtículo

17 Citas (Scopus)

Resumen

The objective of this study was to examine the clinical and genetic variables associated with extra-articular rheumatoid arthritis (ExRA). This was a cross-sectional study in which 538 Northwestern Colombian patients with rheumatoid arthritis (RA) were included. Information about demographics and clinical characteristics including disease activity, inflammatory markers, co-morbidities, cardiovascular (CV) risk factors, history of familial autoimmunity and therapy was recorded. The presence of HLA "shared epitope" (SE) alleles and TNF gene polymorphism was assessed. A multivariate statistical analysis was performed. ExRA was found in 32% of the patients, of which nodulosis, Sjögren's syndrome, and lung involvement were registered in 21%, 9%, and 4% of patients, respectively. Patients with ExRA were older than patients without it and they presented longer disease duration as well. Thus, an association between disease duration and ExRA manifestations was also observed. Patients with ExRA presented significant higher titers of anti-CCP antibodies as compared to patients without ExRA. Hypertension and thrombosis were significantly associated with ExRA. Never having smoked constituted a protective factor against ExRA onset. Associations between ExRA and the presence of traditional CV risk factors were also found. Our results show that duration of RA, CV disease and high titers of anti-CCP antibodies are associated with ExRA in Colombian patients with RA, and highlight the importance of preventing smoking in those who are prone to develop autoimmune diseases including RA. © Clinical Rheumatology 2009.
Idioma originalEnglish (US)
Páginas (desde-hasta)767-775
Número de páginas9
PublicaciónClinical Rheumatology
DOI
EstadoPublished - mar 11 2009

Huella dactilar

Rheumatoid Arthritis
Cardiovascular Diseases
Joints
Anti-Idiotypic Antibodies
Sjogren's Syndrome
Autoimmunity
Autoimmune Diseases
Epitopes
Thrombosis
Multivariate Analysis
Cross-Sectional Studies
Smoking
Alleles
Demography
Hypertension
Morbidity
Lung

Citar esto

Ortega-Hernandez, Oscar Danilo ; Pineda-Tamayo, Ricardo ; Pardo, Aryce L. ; Rojas-Villarraga, Adriana ; Anaya, Juan Manuel. / Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis. En: Clinical Rheumatology. 2009 ; pp. 767-775.
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title = "Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis",
abstract = "The objective of this study was to examine the clinical and genetic variables associated with extra-articular rheumatoid arthritis (ExRA). This was a cross-sectional study in which 538 Northwestern Colombian patients with rheumatoid arthritis (RA) were included. Information about demographics and clinical characteristics including disease activity, inflammatory markers, co-morbidities, cardiovascular (CV) risk factors, history of familial autoimmunity and therapy was recorded. The presence of HLA {"}shared epitope{"} (SE) alleles and TNF gene polymorphism was assessed. A multivariate statistical analysis was performed. ExRA was found in 32{\%} of the patients, of which nodulosis, Sj{\"o}gren's syndrome, and lung involvement were registered in 21{\%}, 9{\%}, and 4{\%} of patients, respectively. Patients with ExRA were older than patients without it and they presented longer disease duration as well. Thus, an association between disease duration and ExRA manifestations was also observed. Patients with ExRA presented significant higher titers of anti-CCP antibodies as compared to patients without ExRA. Hypertension and thrombosis were significantly associated with ExRA. Never having smoked constituted a protective factor against ExRA onset. Associations between ExRA and the presence of traditional CV risk factors were also found. Our results show that duration of RA, CV disease and high titers of anti-CCP antibodies are associated with ExRA in Colombian patients with RA, and highlight the importance of preventing smoking in those who are prone to develop autoimmune diseases including RA. {\circledC} Clinical Rheumatology 2009.",
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Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis. / Ortega-Hernandez, Oscar Danilo; Pineda-Tamayo, Ricardo; Pardo, Aryce L.; Rojas-Villarraga, Adriana; Anaya, Juan Manuel.

En: Clinical Rheumatology, 11.03.2009, p. 767-775.

Resultado de la investigación: Contribución a RevistaArtículo

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AU - Ortega-Hernandez, Oscar Danilo

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AU - Rojas-Villarraga, Adriana

AU - Anaya, Juan Manuel

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N2 - The objective of this study was to examine the clinical and genetic variables associated with extra-articular rheumatoid arthritis (ExRA). This was a cross-sectional study in which 538 Northwestern Colombian patients with rheumatoid arthritis (RA) were included. Information about demographics and clinical characteristics including disease activity, inflammatory markers, co-morbidities, cardiovascular (CV) risk factors, history of familial autoimmunity and therapy was recorded. The presence of HLA "shared epitope" (SE) alleles and TNF gene polymorphism was assessed. A multivariate statistical analysis was performed. ExRA was found in 32% of the patients, of which nodulosis, Sjögren's syndrome, and lung involvement were registered in 21%, 9%, and 4% of patients, respectively. Patients with ExRA were older than patients without it and they presented longer disease duration as well. Thus, an association between disease duration and ExRA manifestations was also observed. Patients with ExRA presented significant higher titers of anti-CCP antibodies as compared to patients without ExRA. Hypertension and thrombosis were significantly associated with ExRA. Never having smoked constituted a protective factor against ExRA onset. Associations between ExRA and the presence of traditional CV risk factors were also found. Our results show that duration of RA, CV disease and high titers of anti-CCP antibodies are associated with ExRA in Colombian patients with RA, and highlight the importance of preventing smoking in those who are prone to develop autoimmune diseases including RA. © Clinical Rheumatology 2009.

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