Cannabinoids for major neurocognitive disorder: Case report and literature review

Título traducido de la contribución: Uso de cannabinoides en trastorno neurocognitivo mayor: reporte de un caso y revisión de la literatura: case report and literature review

Paula M. Herrera Gómez, Sergio A. Ochoa-Orozco, Carolina Jaramillo Toro

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Introduction
Major neurocognitive disorder (MNCD) affects millions of people worldwide. However, the pharmacological options for its management are limited, ineffective and frequently associated with severe adverse reactions.

Case report
An 85-year-old man with history of multiple chronic brain injuries (alcohol-use disorder, haemorrhagic stroke, brain trauma, chronic use of benzodiazepines) developed an MNCD, reaching 7 points on the Reisberg Global Deterioration Scale. He had minimal response to antidepressants, antipsychotics and anticholinergic medications. After the use of mother tincture of Indian hemp (cannabis), a significant improvement was found in his cognitive function, ability to carry out activities of daily living and independence.

Discussion
The endocannabinoid system seems to be implicated in age-related cognitive decline. In addition, the evidence derived from in-vitro and animal models suggest that this system could play an important role in the management of MNCD of different causes.

Conclusions
Cannabinoid treatment for MNCD emerges as a promising therapeutic approach that may benefit a growing number of patients who do not have other treatment options. It is therefore necessary to encourage more research efforts that will help to remove political and scientific barriers to its clinical use.
Título traducido de la contribuciónUso de cannabinoides en trastorno neurocognitivo mayor: reporte de un caso y revisión de la literatura: case report and literature review
Idioma originalEspañol
Número de páginas5
PublicaciónRevista Colombiana de Psiquiatria
Volumen50
N.º1
DOI
EstadoPublicada - ene 1 2021

All Science Journal Classification (ASJC) codes

  • Psiquiatría y salud mental

Concepts

  • !!!Concept
  • Demencia
  • Trastorno neurocognitivo mayor
  • Cannabis
  • Cannabis indica

Huella

Profundice en los temas de investigación de 'Uso de cannabinoides en trastorno neurocognitivo mayor: reporte de un caso y revisión de la literatura: Case report and literature review'. En conjunto forman una huella única.

Citar esto