Bcl-2 antagonist killer 1 (BAK1) polymorphisms influence the risk of developing autoimmune rheumatic diseases in women

A. M. Delgado-Vega, J. Castiblanco, L. M. Gómez, L. M. Diaz-Gallo, A. Rojas-Villarraga, J. M. Anaya

Resultado de la investigación: Contribución a RevistaArtículo

12 Citas (Scopus)

Resumen

Objective: Bcl-2 antagonist killer 1 (BAK1) is a Bcl-2 family proapoptotic member suggested as a candidate gene for autoimmune diseases. The influence of BAK1 polymorphisms on the risk of developing autoimmune rheumatic diseases (AIRDs) in women was investigated. Methods: A total of 719 Colombian women were included in the present study: 209 had systemic lupus erythematosus, 99 primary Sjögren syndrome, 159 rheumatoid arthritis and 252 were healthy matched controls. Tag single nucleotide polymorphisms (SNPs) and potentially functional variants were typed by TaqMan allele discrimination assays. HLA-DRB1 and HLA-DQB1 typing was performed by reverse dot-blot hybridisation and linkage disequilibrium (LD) with BAK1 SNPs was assessed. Results: SNPs rs513349 (odds ratio (OR) 0.57, 95% CI 0.46 to 0.72, p=
Idioma originalEnglish (US)
Páginas (desde-hasta)462-465
Número de páginas4
PublicaciónAnnals of the Rheumatic Diseases
DOI
EstadoPublished - feb 1 2010

Huella dactilar

Rheumatic Diseases
Polymorphism
Autoimmune Diseases
Single Nucleotide Polymorphism
Nucleotides
HLA-DRB1 Chains
Histocompatibility Testing
Sjogren's Syndrome
Linkage Disequilibrium
Systemic Lupus Erythematosus
Rheumatoid Arthritis
Alleles
Odds Ratio
Assays
Genes

Citar esto

Delgado-Vega, A. M. ; Castiblanco, J. ; Gómez, L. M. ; Diaz-Gallo, L. M. ; Rojas-Villarraga, A. ; Anaya, J. M. / Bcl-2 antagonist killer 1 (BAK1) polymorphisms influence the risk of developing autoimmune rheumatic diseases in women. En: Annals of the Rheumatic Diseases. 2010 ; pp. 462-465.
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title = "Bcl-2 antagonist killer 1 (BAK1) polymorphisms influence the risk of developing autoimmune rheumatic diseases in women",
abstract = "Objective: Bcl-2 antagonist killer 1 (BAK1) is a Bcl-2 family proapoptotic member suggested as a candidate gene for autoimmune diseases. The influence of BAK1 polymorphisms on the risk of developing autoimmune rheumatic diseases (AIRDs) in women was investigated. Methods: A total of 719 Colombian women were included in the present study: 209 had systemic lupus erythematosus, 99 primary Sj{\"o}gren syndrome, 159 rheumatoid arthritis and 252 were healthy matched controls. Tag single nucleotide polymorphisms (SNPs) and potentially functional variants were typed by TaqMan allele discrimination assays. HLA-DRB1 and HLA-DQB1 typing was performed by reverse dot-blot hybridisation and linkage disequilibrium (LD) with BAK1 SNPs was assessed. Results: SNPs rs513349 (odds ratio (OR) 0.57, 95{\%} CI 0.46 to 0.72, p=",
author = "Delgado-Vega, {A. M.} and J. Castiblanco and G{\'o}mez, {L. M.} and Diaz-Gallo, {L. M.} and A. Rojas-Villarraga and Anaya, {J. M.}",
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Bcl-2 antagonist killer 1 (BAK1) polymorphisms influence the risk of developing autoimmune rheumatic diseases in women. / Delgado-Vega, A. M.; Castiblanco, J.; Gómez, L. M.; Diaz-Gallo, L. M.; Rojas-Villarraga, A.; Anaya, J. M.

En: Annals of the Rheumatic Diseases, 01.02.2010, p. 462-465.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Bcl-2 antagonist killer 1 (BAK1) polymorphisms influence the risk of developing autoimmune rheumatic diseases in women

AU - Delgado-Vega, A. M.

AU - Castiblanco, J.

AU - Gómez, L. M.

AU - Diaz-Gallo, L. M.

AU - Rojas-Villarraga, A.

AU - Anaya, J. M.

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Objective: Bcl-2 antagonist killer 1 (BAK1) is a Bcl-2 family proapoptotic member suggested as a candidate gene for autoimmune diseases. The influence of BAK1 polymorphisms on the risk of developing autoimmune rheumatic diseases (AIRDs) in women was investigated. Methods: A total of 719 Colombian women were included in the present study: 209 had systemic lupus erythematosus, 99 primary Sjögren syndrome, 159 rheumatoid arthritis and 252 were healthy matched controls. Tag single nucleotide polymorphisms (SNPs) and potentially functional variants were typed by TaqMan allele discrimination assays. HLA-DRB1 and HLA-DQB1 typing was performed by reverse dot-blot hybridisation and linkage disequilibrium (LD) with BAK1 SNPs was assessed. Results: SNPs rs513349 (odds ratio (OR) 0.57, 95% CI 0.46 to 0.72, p=

AB - Objective: Bcl-2 antagonist killer 1 (BAK1) is a Bcl-2 family proapoptotic member suggested as a candidate gene for autoimmune diseases. The influence of BAK1 polymorphisms on the risk of developing autoimmune rheumatic diseases (AIRDs) in women was investigated. Methods: A total of 719 Colombian women were included in the present study: 209 had systemic lupus erythematosus, 99 primary Sjögren syndrome, 159 rheumatoid arthritis and 252 were healthy matched controls. Tag single nucleotide polymorphisms (SNPs) and potentially functional variants were typed by TaqMan allele discrimination assays. HLA-DRB1 and HLA-DQB1 typing was performed by reverse dot-blot hybridisation and linkage disequilibrium (LD) with BAK1 SNPs was assessed. Results: SNPs rs513349 (odds ratio (OR) 0.57, 95% CI 0.46 to 0.72, p=

U2 - 10.1136/ard.2008.100818

DO - 10.1136/ard.2008.100818

M3 - Article

C2 - 19282307

SP - 462

EP - 465

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

ER -