Bacterial translocation in abdominal trauma and postoperative infections

Ernesto Nieves, Luisa F. Tobón, Dora I. Ríos, Andrés Isaza, Miguel Ramírez, Johnny A. Beltrán, Diego Garzón-Ospina, Manuel A. Patarroyo, Arley Gómez

Resultado de la investigación: Contribución a RevistaArtículo

11 Citas (Scopus)

Resumen

BACKGROUND: Bacterial translocation (BT) describes the passage of bacteria residing into the gastrointestinal tract, through the intestinal mucosa barrier to sterile tissues such as mesenteric lymph nodes (MLN) and other organs. This phenomenon has not been thoroughly studied in patients with trauma to date, and an association between BT and postoperative infection has not been well established so far. METHODS: MLNs from 36 patients with abdominal trauma were removed during laparotomy and cultured to detect BT. Postoperative infectious complications in these patients were registered, and both phenotypical and molecular typings (through multilocus sequencing) were carried out for microorganisms isolated from MLN and postoperative infection sites. Associations between clinical variables, BT presence, and postoperative infection development were established. RESULTS: BT was detected in 33% of the patients (n = 12). Postoperative infections were present in 22.2% of the patients (n = 8). A significant statistical difference was found between postoperative infections in patients with BT evidence (41.6%), when compared with patients without BT (12.5%; p = 0.047). Bacteria isolated from infection sites were the same as those cultured in MLN in 40% of the cases (n = 2 of 5), allowing us to establish causality between BT and postoperative infection. CONCLUSIONS: There is higher risk of BT in trauma patients, and it is associated with a significant increase of postoperative infections. An abdominal trauma index ≥10 was found to be associated with the development of BT. This is the first study describing BT among patients with abdominal trauma, where causality is confirmed at molecular level.
Idioma originalEnglish (US)
Páginas (desde-hasta)1258-1261
Número de páginas4
PublicaciónThe Journal of Trauma: Injury, Infection, and Critical Care
DOI
EstadoPublished - nov 1 2011

Huella dactilar

Bacterial Translocation
Wounds and Injuries
Infection
Lymph Nodes
Causality
Bacteria
Molecular Typing
Intestinal Mucosa
Laparotomy
Gastrointestinal Tract

Citar esto

Nieves, E., Tobón, L. F., Ríos, D. I., Isaza, A., Ramírez, M., Beltrán, J. A., ... Gómez, A. (2011). Bacterial translocation in abdominal trauma and postoperative infections. The Journal of Trauma: Injury, Infection, and Critical Care, 1258-1261. https://doi.org/10.1097/TA.0b013e318215140e
Nieves, Ernesto ; Tobón, Luisa F. ; Ríos, Dora I. ; Isaza, Andrés ; Ramírez, Miguel ; Beltrán, Johnny A. ; Garzón-Ospina, Diego ; Patarroyo, Manuel A. ; Gómez, Arley. / Bacterial translocation in abdominal trauma and postoperative infections. En: The Journal of Trauma: Injury, Infection, and Critical Care. 2011 ; pp. 1258-1261.
@article{ba96a34b02484239a38fc81b880b35f3,
title = "Bacterial translocation in abdominal trauma and postoperative infections",
abstract = "BACKGROUND: Bacterial translocation (BT) describes the passage of bacteria residing into the gastrointestinal tract, through the intestinal mucosa barrier to sterile tissues such as mesenteric lymph nodes (MLN) and other organs. This phenomenon has not been thoroughly studied in patients with trauma to date, and an association between BT and postoperative infection has not been well established so far. METHODS: MLNs from 36 patients with abdominal trauma were removed during laparotomy and cultured to detect BT. Postoperative infectious complications in these patients were registered, and both phenotypical and molecular typings (through multilocus sequencing) were carried out for microorganisms isolated from MLN and postoperative infection sites. Associations between clinical variables, BT presence, and postoperative infection development were established. RESULTS: BT was detected in 33{\%} of the patients (n = 12). Postoperative infections were present in 22.2{\%} of the patients (n = 8). A significant statistical difference was found between postoperative infections in patients with BT evidence (41.6{\%}), when compared with patients without BT (12.5{\%}; p = 0.047). Bacteria isolated from infection sites were the same as those cultured in MLN in 40{\%} of the cases (n = 2 of 5), allowing us to establish causality between BT and postoperative infection. CONCLUSIONS: There is higher risk of BT in trauma patients, and it is associated with a significant increase of postoperative infections. An abdominal trauma index ≥10 was found to be associated with the development of BT. This is the first study describing BT among patients with abdominal trauma, where causality is confirmed at molecular level.",
author = "Ernesto Nieves and Tob{\'o}n, {Luisa F.} and R{\'i}os, {Dora I.} and Andr{\'e}s Isaza and Miguel Ram{\'i}rez and Beltr{\'a}n, {Johnny A.} and Diego Garz{\'o}n-Ospina and Patarroyo, {Manuel A.} and Arley G{\'o}mez",
year = "2011",
month = "11",
day = "1",
doi = "10.1097/TA.0b013e318215140e",
language = "English (US)",
pages = "1258--1261",
journal = "Journal of Trauma and Acute Care Surgery",
issn = "2163-0755",
publisher = "Lippincott Williams and Wilkins",

}

Nieves, E, Tobón, LF, Ríos, DI, Isaza, A, Ramírez, M, Beltrán, JA, Garzón-Ospina, D, Patarroyo, MA & Gómez, A 2011, 'Bacterial translocation in abdominal trauma and postoperative infections', The Journal of Trauma: Injury, Infection, and Critical Care, pp. 1258-1261. https://doi.org/10.1097/TA.0b013e318215140e

Bacterial translocation in abdominal trauma and postoperative infections. / Nieves, Ernesto; Tobón, Luisa F.; Ríos, Dora I.; Isaza, Andrés; Ramírez, Miguel; Beltrán, Johnny A.; Garzón-Ospina, Diego; Patarroyo, Manuel A.; Gómez, Arley.

En: The Journal of Trauma: Injury, Infection, and Critical Care, 01.11.2011, p. 1258-1261.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Bacterial translocation in abdominal trauma and postoperative infections

AU - Nieves, Ernesto

AU - Tobón, Luisa F.

AU - Ríos, Dora I.

AU - Isaza, Andrés

AU - Ramírez, Miguel

AU - Beltrán, Johnny A.

AU - Garzón-Ospina, Diego

AU - Patarroyo, Manuel A.

AU - Gómez, Arley

PY - 2011/11/1

Y1 - 2011/11/1

N2 - BACKGROUND: Bacterial translocation (BT) describes the passage of bacteria residing into the gastrointestinal tract, through the intestinal mucosa barrier to sterile tissues such as mesenteric lymph nodes (MLN) and other organs. This phenomenon has not been thoroughly studied in patients with trauma to date, and an association between BT and postoperative infection has not been well established so far. METHODS: MLNs from 36 patients with abdominal trauma were removed during laparotomy and cultured to detect BT. Postoperative infectious complications in these patients were registered, and both phenotypical and molecular typings (through multilocus sequencing) were carried out for microorganisms isolated from MLN and postoperative infection sites. Associations between clinical variables, BT presence, and postoperative infection development were established. RESULTS: BT was detected in 33% of the patients (n = 12). Postoperative infections were present in 22.2% of the patients (n = 8). A significant statistical difference was found between postoperative infections in patients with BT evidence (41.6%), when compared with patients without BT (12.5%; p = 0.047). Bacteria isolated from infection sites were the same as those cultured in MLN in 40% of the cases (n = 2 of 5), allowing us to establish causality between BT and postoperative infection. CONCLUSIONS: There is higher risk of BT in trauma patients, and it is associated with a significant increase of postoperative infections. An abdominal trauma index ≥10 was found to be associated with the development of BT. This is the first study describing BT among patients with abdominal trauma, where causality is confirmed at molecular level.

AB - BACKGROUND: Bacterial translocation (BT) describes the passage of bacteria residing into the gastrointestinal tract, through the intestinal mucosa barrier to sterile tissues such as mesenteric lymph nodes (MLN) and other organs. This phenomenon has not been thoroughly studied in patients with trauma to date, and an association between BT and postoperative infection has not been well established so far. METHODS: MLNs from 36 patients with abdominal trauma were removed during laparotomy and cultured to detect BT. Postoperative infectious complications in these patients were registered, and both phenotypical and molecular typings (through multilocus sequencing) were carried out for microorganisms isolated from MLN and postoperative infection sites. Associations between clinical variables, BT presence, and postoperative infection development were established. RESULTS: BT was detected in 33% of the patients (n = 12). Postoperative infections were present in 22.2% of the patients (n = 8). A significant statistical difference was found between postoperative infections in patients with BT evidence (41.6%), when compared with patients without BT (12.5%; p = 0.047). Bacteria isolated from infection sites were the same as those cultured in MLN in 40% of the cases (n = 2 of 5), allowing us to establish causality between BT and postoperative infection. CONCLUSIONS: There is higher risk of BT in trauma patients, and it is associated with a significant increase of postoperative infections. An abdominal trauma index ≥10 was found to be associated with the development of BT. This is the first study describing BT among patients with abdominal trauma, where causality is confirmed at molecular level.

U2 - 10.1097/TA.0b013e318215140e

DO - 10.1097/TA.0b013e318215140e

M3 - Article

SP - 1258

EP - 1261

JO - Journal of Trauma and Acute Care Surgery

JF - Journal of Trauma and Acute Care Surgery

SN - 2163-0755

ER -