Autoimmune thyroid disease in Colombian patients with systemic lupus erythematosus

Juan Sebastian Franco, Jenny Amaya-Amaya, Nicolás Molano-González, Julian Caro-Moreno, Mõnica Rodríguez-Jiménez, Yeny Acosta-Ampudia, Rubén D. Mantilla, Adriana Rojas-Villarraga, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaArtículo

17 Citas (Scopus)

Resumen

© 2014 John Wiley & Sons Ltd.Objectives To determine the prevalence and the predictive factors of autoimmune hypothyroidism (AH) within a systemic lupus erythematosus (SLE) cohort and to analyse the current information concerning the prevalence and impact of autoimmune thyroid disease (AITD) and thyroid autoimmunity in patients with SLE. Methods A total of 376 patients with SLE were assessed for the presence of the following: (i) confirmed AH, (ii) positive thy-roperoxidase/thyroglobulin antibodies [TPOAb/TgAb] without hypothyroidism, (iii) nonautoimmune hypothyroidism and (iv) SLE patients with neither. Multivariate analysis and a classification and regression tree model were used to analyse data. The current information was discussed through a systematic literature review (SLR). Results In our cohort, the prevalence of confirmed AH was 12%. However, in euthyroid patients with SLE, TPOAb and TgAb were observed in 21% and 10%, respectively. Patients with confirmed AH were significantly older and had later age at onset of the disease. Smoking (adjusted odds ratio (AOR) 6·93, 95% CI 1·98-28·54, P = 0·004), Sjögren's Syndrome (SS) (AOR 23·2, 95% CI 1·89-359·53, P = 0·015) and positivity for anticyclic citrullinated peptide (anti-CCP) (AOR 10·35, 95% CI 1·04-121·26, P = 0·047) were associated with AH-SLE, regardless of gender and duration of the disease. Smoking and SS were confirmed as predictors of AH-SLE. In the SLR, the prevalence of AITD ranged from 1% to 60%. The factors associated with this polyautoimmunity were female gender, older age, smoking, certain autoantibodies, SS, and cutaneous and articular involvement. Conclusions AITD is frequent in SLE and does not affect the severity of SLE. Identified risk factors will assist clinicians in the search for AITD. Our results encourage smoke-free policies in patients with SLE.
Idioma originalEnglish (US)
Páginas (desde-hasta)943-950
Número de páginas8
PublicaciónClinical Endocrinology
DOI
EstadoPublished - dic 1 2015

Huella dactilar

Thyroid Diseases
Systemic Lupus Erythematosus
Autoimmune Diseases
Sjogren's Syndrome
Smoking
Odds Ratio
Smoke-Free Policy
Thyroglobulin
Hypothyroidism
Nuclear Family
Autoimmunity
Age of Onset
Autoantibodies
Autoimmune Hypothyroidism
Thyroid Gland
Cohort Studies
Multivariate Analysis
Joints
Skin
Peptides

Citar esto

Franco, Juan Sebastian ; Amaya-Amaya, Jenny ; Molano-González, Nicolás ; Caro-Moreno, Julian ; Rodríguez-Jiménez, Mõnica ; Acosta-Ampudia, Yeny ; Mantilla, Rubén D. ; Rojas-Villarraga, Adriana ; Anaya, Juan Manuel. / Autoimmune thyroid disease in Colombian patients with systemic lupus erythematosus. En: Clinical Endocrinology. 2015 ; pp. 943-950.
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title = "Autoimmune thyroid disease in Colombian patients with systemic lupus erythematosus",
abstract = "{\circledC} 2014 John Wiley & Sons Ltd.Objectives To determine the prevalence and the predictive factors of autoimmune hypothyroidism (AH) within a systemic lupus erythematosus (SLE) cohort and to analyse the current information concerning the prevalence and impact of autoimmune thyroid disease (AITD) and thyroid autoimmunity in patients with SLE. Methods A total of 376 patients with SLE were assessed for the presence of the following: (i) confirmed AH, (ii) positive thy-roperoxidase/thyroglobulin antibodies [TPOAb/TgAb] without hypothyroidism, (iii) nonautoimmune hypothyroidism and (iv) SLE patients with neither. Multivariate analysis and a classification and regression tree model were used to analyse data. The current information was discussed through a systematic literature review (SLR). Results In our cohort, the prevalence of confirmed AH was 12{\%}. However, in euthyroid patients with SLE, TPOAb and TgAb were observed in 21{\%} and 10{\%}, respectively. Patients with confirmed AH were significantly older and had later age at onset of the disease. Smoking (adjusted odds ratio (AOR) 6·93, 95{\%} CI 1·98-28·54, P = 0·004), Sj{\"o}gren's Syndrome (SS) (AOR 23·2, 95{\%} CI 1·89-359·53, P = 0·015) and positivity for anticyclic citrullinated peptide (anti-CCP) (AOR 10·35, 95{\%} CI 1·04-121·26, P = 0·047) were associated with AH-SLE, regardless of gender and duration of the disease. Smoking and SS were confirmed as predictors of AH-SLE. In the SLR, the prevalence of AITD ranged from 1{\%} to 60{\%}. The factors associated with this polyautoimmunity were female gender, older age, smoking, certain autoantibodies, SS, and cutaneous and articular involvement. Conclusions AITD is frequent in SLE and does not affect the severity of SLE. Identified risk factors will assist clinicians in the search for AITD. Our results encourage smoke-free policies in patients with SLE.",
author = "Franco, {Juan Sebastian} and Jenny Amaya-Amaya and Nicol{\'a}s Molano-Gonz{\'a}lez and Julian Caro-Moreno and M{\~o}nica Rodr{\'i}guez-Jim{\'e}nez and Yeny Acosta-Ampudia and Mantilla, {Rub{\'e}n D.} and Adriana Rojas-Villarraga and Anaya, {Juan Manuel}",
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doi = "10.1111/cen.12662",
language = "English (US)",
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issn = "0300-0664",
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Franco, JS, Amaya-Amaya, J, Molano-González, N, Caro-Moreno, J, Rodríguez-Jiménez, M, Acosta-Ampudia, Y, Mantilla, RD, Rojas-Villarraga, A & Anaya, JM 2015, 'Autoimmune thyroid disease in Colombian patients with systemic lupus erythematosus', Clinical Endocrinology, pp. 943-950. https://doi.org/10.1111/cen.12662

Autoimmune thyroid disease in Colombian patients with systemic lupus erythematosus. / Franco, Juan Sebastian; Amaya-Amaya, Jenny; Molano-González, Nicolás; Caro-Moreno, Julian; Rodríguez-Jiménez, Mõnica; Acosta-Ampudia, Yeny; Mantilla, Rubén D.; Rojas-Villarraga, Adriana; Anaya, Juan Manuel.

En: Clinical Endocrinology, 01.12.2015, p. 943-950.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Autoimmune thyroid disease in Colombian patients with systemic lupus erythematosus

AU - Franco, Juan Sebastian

AU - Amaya-Amaya, Jenny

AU - Molano-González, Nicolás

AU - Caro-Moreno, Julian

AU - Rodríguez-Jiménez, Mõnica

AU - Acosta-Ampudia, Yeny

AU - Mantilla, Rubén D.

AU - Rojas-Villarraga, Adriana

AU - Anaya, Juan Manuel

PY - 2015/12/1

Y1 - 2015/12/1

N2 - © 2014 John Wiley & Sons Ltd.Objectives To determine the prevalence and the predictive factors of autoimmune hypothyroidism (AH) within a systemic lupus erythematosus (SLE) cohort and to analyse the current information concerning the prevalence and impact of autoimmune thyroid disease (AITD) and thyroid autoimmunity in patients with SLE. Methods A total of 376 patients with SLE were assessed for the presence of the following: (i) confirmed AH, (ii) positive thy-roperoxidase/thyroglobulin antibodies [TPOAb/TgAb] without hypothyroidism, (iii) nonautoimmune hypothyroidism and (iv) SLE patients with neither. Multivariate analysis and a classification and regression tree model were used to analyse data. The current information was discussed through a systematic literature review (SLR). Results In our cohort, the prevalence of confirmed AH was 12%. However, in euthyroid patients with SLE, TPOAb and TgAb were observed in 21% and 10%, respectively. Patients with confirmed AH were significantly older and had later age at onset of the disease. Smoking (adjusted odds ratio (AOR) 6·93, 95% CI 1·98-28·54, P = 0·004), Sjögren's Syndrome (SS) (AOR 23·2, 95% CI 1·89-359·53, P = 0·015) and positivity for anticyclic citrullinated peptide (anti-CCP) (AOR 10·35, 95% CI 1·04-121·26, P = 0·047) were associated with AH-SLE, regardless of gender and duration of the disease. Smoking and SS were confirmed as predictors of AH-SLE. In the SLR, the prevalence of AITD ranged from 1% to 60%. The factors associated with this polyautoimmunity were female gender, older age, smoking, certain autoantibodies, SS, and cutaneous and articular involvement. Conclusions AITD is frequent in SLE and does not affect the severity of SLE. Identified risk factors will assist clinicians in the search for AITD. Our results encourage smoke-free policies in patients with SLE.

AB - © 2014 John Wiley & Sons Ltd.Objectives To determine the prevalence and the predictive factors of autoimmune hypothyroidism (AH) within a systemic lupus erythematosus (SLE) cohort and to analyse the current information concerning the prevalence and impact of autoimmune thyroid disease (AITD) and thyroid autoimmunity in patients with SLE. Methods A total of 376 patients with SLE were assessed for the presence of the following: (i) confirmed AH, (ii) positive thy-roperoxidase/thyroglobulin antibodies [TPOAb/TgAb] without hypothyroidism, (iii) nonautoimmune hypothyroidism and (iv) SLE patients with neither. Multivariate analysis and a classification and regression tree model were used to analyse data. The current information was discussed through a systematic literature review (SLR). Results In our cohort, the prevalence of confirmed AH was 12%. However, in euthyroid patients with SLE, TPOAb and TgAb were observed in 21% and 10%, respectively. Patients with confirmed AH were significantly older and had later age at onset of the disease. Smoking (adjusted odds ratio (AOR) 6·93, 95% CI 1·98-28·54, P = 0·004), Sjögren's Syndrome (SS) (AOR 23·2, 95% CI 1·89-359·53, P = 0·015) and positivity for anticyclic citrullinated peptide (anti-CCP) (AOR 10·35, 95% CI 1·04-121·26, P = 0·047) were associated with AH-SLE, regardless of gender and duration of the disease. Smoking and SS were confirmed as predictors of AH-SLE. In the SLR, the prevalence of AITD ranged from 1% to 60%. The factors associated with this polyautoimmunity were female gender, older age, smoking, certain autoantibodies, SS, and cutaneous and articular involvement. Conclusions AITD is frequent in SLE and does not affect the severity of SLE. Identified risk factors will assist clinicians in the search for AITD. Our results encourage smoke-free policies in patients with SLE.

U2 - 10.1111/cen.12662

DO - 10.1111/cen.12662

M3 - Article

C2 - 25382266

SP - 943

EP - 950

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

ER -