TY - JOUR
T1 - Autoimmune Neurological Conditions Associated With Zika Virus Infection
AU - Acosta-Ampudia, Yeny
AU - Monsalve, Diana M.
AU - Castillo-Medina, Luis F.
AU - Rodríguez, Yhojan
AU - Pacheco, Yovana
AU - Halstead, Susan
AU - Willison, Hugh J.
AU - Anaya, Juan Manuel
AU - Ramírez-Santana, Carolina
N1 - Funding Information:
This work was supported by Universidad del Rosario (ABN011) and Colciencias (747-2016), Bogota, Colombia.
Publisher Copyright:
© 2018 Acosta-Ampudia, Monsalve, Castillo-Medina, Rodríguez, Pacheco, Halstead, Willison, Anaya and Ramírez-Santana.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/4/11
Y1 - 2018/4/11
N2 - Zika virus (ZIKV) is an emerging flavivirus rapidly spreading throughout the tropical Americas. Aedes mosquitoes is the principal way of transmission of the virus to humans. ZIKV can be spread by transplacental, perinatal, and body fluids. ZIKV infection is often asymptomatic and those with symptoms present minor illness after 3 to 12 days of incubation, characterized by a mild and self-limiting disease with low-grade fever, conjunctivitis, widespread pruritic maculopapular rash, arthralgia and myalgia. ZIKV has been linked to a number of central and peripheral nervous system injuries such as Guillain-Barré syndrome (GBS), transverse myelitis (TM), meningoencephalitis, ophthalmological manifestations, and other neurological complications. Nevertheless, mechanisms of host-pathogen neuro-immune interactions remain incompletely elucidated. This review provides a critical discussion about the possible mechanisms underlying the development of autoimmune neurological conditions associated with Zika virus infection.
AB - Zika virus (ZIKV) is an emerging flavivirus rapidly spreading throughout the tropical Americas. Aedes mosquitoes is the principal way of transmission of the virus to humans. ZIKV can be spread by transplacental, perinatal, and body fluids. ZIKV infection is often asymptomatic and those with symptoms present minor illness after 3 to 12 days of incubation, characterized by a mild and self-limiting disease with low-grade fever, conjunctivitis, widespread pruritic maculopapular rash, arthralgia and myalgia. ZIKV has been linked to a number of central and peripheral nervous system injuries such as Guillain-Barré syndrome (GBS), transverse myelitis (TM), meningoencephalitis, ophthalmological manifestations, and other neurological complications. Nevertheless, mechanisms of host-pathogen neuro-immune interactions remain incompletely elucidated. This review provides a critical discussion about the possible mechanisms underlying the development of autoimmune neurological conditions associated with Zika virus infection.
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U2 - 10.3389/fnmol.2018.00116
DO - 10.3389/fnmol.2018.00116
M3 - Review article
AN - SCOPUS:85046904587
SN - 1662-5099
VL - 11
JO - Frontiers in Molecular Neuroscience
JF - Frontiers in Molecular Neuroscience
M1 - 116
ER -
