Autoimmune diseases in the intensive care unit. An update

Olga L. Quintero, Adriana Rojas-Villarraga, Ruben D. Mantilla, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaRevisión Literaria

30 Citas (Scopus)

Resumen

Autoimmune diseases (ADs) are a challenge at the intensive care unit. The management of patients with these diseases in the critical care setting has improved over time since there are new and more aggressive alternatives to treat and diagnose them. We aimed to review the current causes of admission, clinical features, outcomes and variables associated with mortality of patients with ADs admitted to the intensive care unit (ICU). International classification criteria for ADs were used to include patients. Search was done through PubMed, SCOPUS, SciELO, and LILACS databases up to December of 2011.Twenty-nine case series and forty-one case reports were analyzed after quality assessment. Respiratory involvement was the leading cause of admission. Systemic lupus erythematosus (SLE) (33.5% of reported patients), rheumatoid arthritis (25%) and systemic vasculitis (15%) were the most frequent ADs in patients admitted to the ICU in the last decade. Mortality ranged from 17% to 55% in case series including all ADs, but in the ones that only included patients with a specific AD, such as SLE, it reached up to 79%. High APACHE score, multi-organ dysfunction, older age and cytopenia were the most reported variables associated with mortality. In conclusion, ADs should always be considered in patients with life threatening conditions that warrant critical care. Variables influencing mortality should be promptly identified in order to improve the patients' outcomes. © 2012 Elsevier B.V.
Idioma originalEnglish (US)
Páginas (desde-hasta)380-395
Número de páginas16
PublicaciónAutoimmunity Reviews
DOI
EstadoPublished - ene 1 2013

Huella dactilar

Autoimmune Diseases
Intensive Care Units
Mortality
Critical Care
Systemic Lupus Erythematosus
Organ Dysfunction Scores
Systemic Vasculitis
APACHE
PubMed
Rheumatoid Arthritis
Databases

Citar esto

Quintero, O. L., Rojas-Villarraga, A., Mantilla, R. D., & Anaya, J. M. (2013). Autoimmune diseases in the intensive care unit. An update. Autoimmunity Reviews, 380-395. https://doi.org/10.1016/j.autrev.2012.06.002
Quintero, Olga L. ; Rojas-Villarraga, Adriana ; Mantilla, Ruben D. ; Anaya, Juan Manuel. / Autoimmune diseases in the intensive care unit. An update. En: Autoimmunity Reviews. 2013 ; pp. 380-395.
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Quintero, OL, Rojas-Villarraga, A, Mantilla, RD & Anaya, JM 2013, 'Autoimmune diseases in the intensive care unit. An update', Autoimmunity Reviews, pp. 380-395. https://doi.org/10.1016/j.autrev.2012.06.002

Autoimmune diseases in the intensive care unit. An update. / Quintero, Olga L.; Rojas-Villarraga, Adriana; Mantilla, Ruben D.; Anaya, Juan Manuel.

En: Autoimmunity Reviews, 01.01.2013, p. 380-395.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

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AU - Mantilla, Ruben D.

AU - Anaya, Juan Manuel

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N2 - Autoimmune diseases (ADs) are a challenge at the intensive care unit. The management of patients with these diseases in the critical care setting has improved over time since there are new and more aggressive alternatives to treat and diagnose them. We aimed to review the current causes of admission, clinical features, outcomes and variables associated with mortality of patients with ADs admitted to the intensive care unit (ICU). International classification criteria for ADs were used to include patients. Search was done through PubMed, SCOPUS, SciELO, and LILACS databases up to December of 2011.Twenty-nine case series and forty-one case reports were analyzed after quality assessment. Respiratory involvement was the leading cause of admission. Systemic lupus erythematosus (SLE) (33.5% of reported patients), rheumatoid arthritis (25%) and systemic vasculitis (15%) were the most frequent ADs in patients admitted to the ICU in the last decade. Mortality ranged from 17% to 55% in case series including all ADs, but in the ones that only included patients with a specific AD, such as SLE, it reached up to 79%. High APACHE score, multi-organ dysfunction, older age and cytopenia were the most reported variables associated with mortality. In conclusion, ADs should always be considered in patients with life threatening conditions that warrant critical care. Variables influencing mortality should be promptly identified in order to improve the patients' outcomes. © 2012 Elsevier B.V.

AB - Autoimmune diseases (ADs) are a challenge at the intensive care unit. The management of patients with these diseases in the critical care setting has improved over time since there are new and more aggressive alternatives to treat and diagnose them. We aimed to review the current causes of admission, clinical features, outcomes and variables associated with mortality of patients with ADs admitted to the intensive care unit (ICU). International classification criteria for ADs were used to include patients. Search was done through PubMed, SCOPUS, SciELO, and LILACS databases up to December of 2011.Twenty-nine case series and forty-one case reports were analyzed after quality assessment. Respiratory involvement was the leading cause of admission. Systemic lupus erythematosus (SLE) (33.5% of reported patients), rheumatoid arthritis (25%) and systemic vasculitis (15%) were the most frequent ADs in patients admitted to the ICU in the last decade. Mortality ranged from 17% to 55% in case series including all ADs, but in the ones that only included patients with a specific AD, such as SLE, it reached up to 79%. High APACHE score, multi-organ dysfunction, older age and cytopenia were the most reported variables associated with mortality. In conclusion, ADs should always be considered in patients with life threatening conditions that warrant critical care. Variables influencing mortality should be promptly identified in order to improve the patients' outcomes. © 2012 Elsevier B.V.

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