Astroglial role in the pathophysiology of status epilepticus: an overview

Rodrigo Esteban Gonzalez Reyes, Karina Vargas-Sánchez, Maria Mogilevskaya, John Rodríguez-Pérez, María Graciela Rubiano, José Julián Javela

Resultado de la investigación: Contribución a RevistaArtículo de revisión

  • 1 Citas

Resumen

El estado epiléptico es una emergencia médica con morbilidad y mortalidad elevadas,
y representa una causa principal de muertes relacionadas con la epilepsia. Aunque el estado
epilepticus puede ocurrir a cualquier edad, se manifiesta más probablemente en niños y ancianos
gente. A pesar de la prevalencia común de trastornos epilépticos, una explicación completa
para los mecanismos que conducen al desarrollo de convulsiones autolimitadas o de larga duración
(como en el estado epiléptico) siguen faltando. Aparte de las neuronas, la evidencia de la investigación
sugiere la implicación de células inmunes y gliales en la epileptogénesis. Entre los gliales
células, los astrocitos representan un blanco ideal para el estudio de la fisiopatología de
estado epiléptico, debido a su papel clave en el equilibrio homeostático del sistema nervioso central.
sistema. Durante el estado epiléptico, las células astrogliales se activan por la presencia de
citoquinas, patrones moleculares asociados al daño y especies reactivas de oxígeno. La activación persistente de los astrocitos lleva a una disminución de la depuración del glutamato con una
acumulación correspondiente en el espacio sináptico extracelular, aumentando la probabilidad
de excitotoxicidad neuronal. Además, alteraciones importantes en la unión del espacio astrocítico
de acoplamiento, inflamación y expresión de los receptores, facilitan la generación de convulsiones.
Los astrocitos también están involucrados en la desregulación de la transmisión inhibitoria en el cerebro central.
el sistema nervioso y participar directamente en las alteraciones homeostáticas iónicas durante el estado
epiléptico. En la presente revisión, nos centramos en los cambios funcionales y estructurales
en la actividad astrocítica que participan en el desarrollo y mantenimiento del estado
epiléptico, con especial atención a las alteraciones inflamatorias concurrentes. También
incluir objetivos potenciales de tratamiento astrocítico para el estado epiléptico.
Título traducido de la contribuciónPapel de los astrocitos en la fisiopatología del estatus epiléptico: una revisión.
IdiomaEnglish (US)
Páginas26954-26976
PublicaciónOncotarget
Volumen9
DOI
EstadoPublished - jun 1 2018

Huella dactilar

Status Epilepticus
Astrocytes
Neuroglia
Seizures
Central Nervous System
Gap Junctions
Extracellular Space
Glutamic Acid
Epilepsy
Reactive Oxygen Species
Emergencies
Maintenance
Cytokines
Inflammation
Morbidity
Neurons
Mortality
Research

Citar esto

Gonzalez Reyes, R. E., Vargas-Sánchez, K., Mogilevskaya, M., Rodríguez-Pérez, J., Rubiano, M. G., & Javela, J. J. (2018). Astroglial role in the pathophysiology of status epilepticus: an overview. Oncotarget, 9, 26954-26976. https://doi.org/10.18632/oncotarget.25485
Gonzalez Reyes, Rodrigo Esteban ; Vargas-Sánchez, Karina ; Mogilevskaya, Maria ; Rodríguez-Pérez, John ; Rubiano, María Graciela ; Javela, José Julián. / Astroglial role in the pathophysiology of status epilepticus: an overview. En: Oncotarget. 2018 ; Vol. 9. pp. 26954-26976.
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abstract = "Status epilepticus is a medical emergency with elevated morbidity and mortality rates, and represents a leading cause of epilepsy-related deaths. Though status epilepticus can occur at any age, it manifests more likely in children and elderly people. Despite the common prevalence of epileptic disorders, a complete explanation for the mechanisms leading to development of self-limited or long lasting seizures (as in status epilepticus) are still lacking. Apart from neurons, research evidence suggests the involvement of immune and glial cells in epileptogenesis. Among glial cells, astrocytes represent an ideal target for the study of the pathophysiology of status epilepticus, due to their key role in homeostatic balance of the central nervous system. During status epilepticus, astroglial cells are activated by the presence of cytokines, damage associated molecular patterns and reactive oxygen species. The persistent activation of astrocytes leads to a decrease in glutamate clearance with a corresponding accumulation in the synaptic extracellular space, increasing the chance of neuronal excitotoxicity. Moreover, major alterations in astrocytic gap junction coupling, inflammation and receptor expression, facilitate the generation of seizures. Astrocytes are also involved in dysregulation of inhibitory transmission in the central nervous system and directly participate in ionic homeostatic alterations during status epilepticus. In the present review, we focus on the functional and structural changes in astrocytic activity that participate in the development and maintenance of status epilepticus, with special attention on concurrent inflammatory alterations. We also include potential astrocytic treatment targets for status epilepticus.",
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Gonzalez Reyes, RE, Vargas-Sánchez, K, Mogilevskaya, M, Rodríguez-Pérez, J, Rubiano, MG & Javela, JJ 2018, 'Astroglial role in the pathophysiology of status epilepticus: an overview' Oncotarget, vol. 9, pp. 26954-26976. https://doi.org/10.18632/oncotarget.25485

Astroglial role in the pathophysiology of status epilepticus: an overview. / Gonzalez Reyes, Rodrigo Esteban; Vargas-Sánchez, Karina; Mogilevskaya, Maria; Rodríguez-Pérez, John; Rubiano, María Graciela; Javela, José Julián.

En: Oncotarget, Vol. 9, 01.06.2018, p. 26954-26976.

Resultado de la investigación: Contribución a RevistaArtículo de revisión

TY - JOUR

T1 - Astroglial role in the pathophysiology of status epilepticus: an overview

AU - Gonzalez Reyes, Rodrigo Esteban

AU - Vargas-Sánchez, Karina

AU - Mogilevskaya, Maria

AU - Rodríguez-Pérez, John

AU - Rubiano, María Graciela

AU - Javela, José Julián

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Status epilepticus is a medical emergency with elevated morbidity and mortality rates, and represents a leading cause of epilepsy-related deaths. Though status epilepticus can occur at any age, it manifests more likely in children and elderly people. Despite the common prevalence of epileptic disorders, a complete explanation for the mechanisms leading to development of self-limited or long lasting seizures (as in status epilepticus) are still lacking. Apart from neurons, research evidence suggests the involvement of immune and glial cells in epileptogenesis. Among glial cells, astrocytes represent an ideal target for the study of the pathophysiology of status epilepticus, due to their key role in homeostatic balance of the central nervous system. During status epilepticus, astroglial cells are activated by the presence of cytokines, damage associated molecular patterns and reactive oxygen species. The persistent activation of astrocytes leads to a decrease in glutamate clearance with a corresponding accumulation in the synaptic extracellular space, increasing the chance of neuronal excitotoxicity. Moreover, major alterations in astrocytic gap junction coupling, inflammation and receptor expression, facilitate the generation of seizures. Astrocytes are also involved in dysregulation of inhibitory transmission in the central nervous system and directly participate in ionic homeostatic alterations during status epilepticus. In the present review, we focus on the functional and structural changes in astrocytic activity that participate in the development and maintenance of status epilepticus, with special attention on concurrent inflammatory alterations. We also include potential astrocytic treatment targets for status epilepticus.

AB - Status epilepticus is a medical emergency with elevated morbidity and mortality rates, and represents a leading cause of epilepsy-related deaths. Though status epilepticus can occur at any age, it manifests more likely in children and elderly people. Despite the common prevalence of epileptic disorders, a complete explanation for the mechanisms leading to development of self-limited or long lasting seizures (as in status epilepticus) are still lacking. Apart from neurons, research evidence suggests the involvement of immune and glial cells in epileptogenesis. Among glial cells, astrocytes represent an ideal target for the study of the pathophysiology of status epilepticus, due to their key role in homeostatic balance of the central nervous system. During status epilepticus, astroglial cells are activated by the presence of cytokines, damage associated molecular patterns and reactive oxygen species. The persistent activation of astrocytes leads to a decrease in glutamate clearance with a corresponding accumulation in the synaptic extracellular space, increasing the chance of neuronal excitotoxicity. Moreover, major alterations in astrocytic gap junction coupling, inflammation and receptor expression, facilitate the generation of seizures. Astrocytes are also involved in dysregulation of inhibitory transmission in the central nervous system and directly participate in ionic homeostatic alterations during status epilepticus. In the present review, we focus on the functional and structural changes in astrocytic activity that participate in the development and maintenance of status epilepticus, with special attention on concurrent inflammatory alterations. We also include potential astrocytic treatment targets for status epilepticus.

U2 - 10.18632/oncotarget.25485

DO - 10.18632/oncotarget.25485

M3 - Review article

VL - 9

SP - 26954

EP - 26976

JO - Oncotarget

T2 - Oncotarget

JF - Oncotarget

SN - 1949-2553

ER -

Gonzalez Reyes RE, Vargas-Sánchez K, Mogilevskaya M, Rodríguez-Pérez J, Rubiano MG, Javela JJ. Astroglial role in the pathophysiology of status epilepticus: an overview. Oncotarget. 2018 jun 1;9:26954-26976. https://doi.org/10.18632/oncotarget.25485