Association between Secondary and Primary Sjögren's Syndrome in a Large Collection of Lupus Families

Rachna Aggarwal, Juan Manuel Anaya, Kristi A. Koelsch, Biji T. Kurien, R. Hal Scofield

Resultado de la investigación: Contribución a RevistaArtículo

5 Citas (Scopus)

Resumen

© 2015 Rachna Aggarwal et al.Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) share clinical and immunogenetic features and may occur together. We undertook this study to determine the risk of primary SS among SLE-unaffected relatives of SLE patients and whether or not primary and secondary SS tended to occur in the same families. Methods. We collected clinical and serological data on 2694 SLE patients, 7390 SLE-unaffected relatives of the SLE patients, and 1470 matched controls. Results. Of the 2694 subjects with SLE, 548 had secondary SS, while 71 of their 7390 SLE-unaffected relatives had primary SS. None of the 1470 controls had SS as defined herein (p = 5 × 10-5 compared to SLE-unaffected relatives). Of the 71 SLE-unaffected relatives with primary SS, 18 (25.3%) had an SLE-affected family member with secondary SS, while only 530 of the 7319 (7.2%) SLE-unaffected relatives without SS did so (p = 1 × 10-8). Conclusion. Among families identified for the presence of SLE, primary and secondary SS tend to occur within the same families. These results highlight the commonalities between these two forms of SS, which in fact correspond to the same disease.
Idioma originalEnglish (US)
PublicaciónAutoimmune Diseases
DOI
EstadoPublished - ene 1 2015

Huella dactilar

Sjogren's Syndrome
Systemic Lupus Erythematosus
Immunogenetics

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@article{953b4233c239423dbf6d3fd7c0273e8b,
title = "Association between Secondary and Primary Sj{\"o}gren's Syndrome in a Large Collection of Lupus Families",
abstract = "{\circledC} 2015 Rachna Aggarwal et al.Systemic lupus erythematosus (SLE) and Sj{\"o}gren's syndrome (SS) share clinical and immunogenetic features and may occur together. We undertook this study to determine the risk of primary SS among SLE-unaffected relatives of SLE patients and whether or not primary and secondary SS tended to occur in the same families. Methods. We collected clinical and serological data on 2694 SLE patients, 7390 SLE-unaffected relatives of the SLE patients, and 1470 matched controls. Results. Of the 2694 subjects with SLE, 548 had secondary SS, while 71 of their 7390 SLE-unaffected relatives had primary SS. None of the 1470 controls had SS as defined herein (p = 5 × 10-5 compared to SLE-unaffected relatives). Of the 71 SLE-unaffected relatives with primary SS, 18 (25.3{\%}) had an SLE-affected family member with secondary SS, while only 530 of the 7319 (7.2{\%}) SLE-unaffected relatives without SS did so (p = 1 × 10-8). Conclusion. Among families identified for the presence of SLE, primary and secondary SS tend to occur within the same families. These results highlight the commonalities between these two forms of SS, which in fact correspond to the same disease.",
author = "Rachna Aggarwal and Anaya, {Juan Manuel} and Koelsch, {Kristi A.} and Kurien, {Biji T.} and Scofield, {R. Hal}",
year = "2015",
month = "1",
day = "1",
doi = "10.1155/2015/298506",
language = "English (US)",
journal = "Autoimmune Diseases",
issn = "2090-0422",
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Association between Secondary and Primary Sjögren's Syndrome in a Large Collection of Lupus Families. / Aggarwal, Rachna; Anaya, Juan Manuel; Koelsch, Kristi A.; Kurien, Biji T.; Scofield, R. Hal.

En: Autoimmune Diseases, 01.01.2015.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Association between Secondary and Primary Sjögren's Syndrome in a Large Collection of Lupus Families

AU - Aggarwal, Rachna

AU - Anaya, Juan Manuel

AU - Koelsch, Kristi A.

AU - Kurien, Biji T.

AU - Scofield, R. Hal

PY - 2015/1/1

Y1 - 2015/1/1

N2 - © 2015 Rachna Aggarwal et al.Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) share clinical and immunogenetic features and may occur together. We undertook this study to determine the risk of primary SS among SLE-unaffected relatives of SLE patients and whether or not primary and secondary SS tended to occur in the same families. Methods. We collected clinical and serological data on 2694 SLE patients, 7390 SLE-unaffected relatives of the SLE patients, and 1470 matched controls. Results. Of the 2694 subjects with SLE, 548 had secondary SS, while 71 of their 7390 SLE-unaffected relatives had primary SS. None of the 1470 controls had SS as defined herein (p = 5 × 10-5 compared to SLE-unaffected relatives). Of the 71 SLE-unaffected relatives with primary SS, 18 (25.3%) had an SLE-affected family member with secondary SS, while only 530 of the 7319 (7.2%) SLE-unaffected relatives without SS did so (p = 1 × 10-8). Conclusion. Among families identified for the presence of SLE, primary and secondary SS tend to occur within the same families. These results highlight the commonalities between these two forms of SS, which in fact correspond to the same disease.

AB - © 2015 Rachna Aggarwal et al.Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) share clinical and immunogenetic features and may occur together. We undertook this study to determine the risk of primary SS among SLE-unaffected relatives of SLE patients and whether or not primary and secondary SS tended to occur in the same families. Methods. We collected clinical and serological data on 2694 SLE patients, 7390 SLE-unaffected relatives of the SLE patients, and 1470 matched controls. Results. Of the 2694 subjects with SLE, 548 had secondary SS, while 71 of their 7390 SLE-unaffected relatives had primary SS. None of the 1470 controls had SS as defined herein (p = 5 × 10-5 compared to SLE-unaffected relatives). Of the 71 SLE-unaffected relatives with primary SS, 18 (25.3%) had an SLE-affected family member with secondary SS, while only 530 of the 7319 (7.2%) SLE-unaffected relatives without SS did so (p = 1 × 10-8). Conclusion. Among families identified for the presence of SLE, primary and secondary SS tend to occur within the same families. These results highlight the commonalities between these two forms of SS, which in fact correspond to the same disease.

U2 - 10.1155/2015/298506

DO - 10.1155/2015/298506

M3 - Article

C2 - 26246904

JO - Autoimmune Diseases

JF - Autoimmune Diseases

SN - 2090-0422

ER -