Asociación entre el genotipo FTO (ns9939609) y los marcadores de adiposidad en adultos chilenos

Fanny Petermann, Marcelo Villagrán, Claudia Troncoso, Lorena Mardones, Ana María Leiva, María Adela Martínez, Alex Garrido-Méndez, Felipe Poblete-Valderrama, Carlos Salas-Bravo, Robinson Ramírez-Vélez, Natalia Ulloa, Francisco Pérez-Bravo, Carlos Celis-Morales

Resultado de la investigación: Contribución a RevistaArtículo

Resumen

Antecedentes:
Numerosos estudios han identificado el papel del gen asociado a la grasa en el desarrollo de la obesidad.

Apunta:
Investigar la asociación del gen FTO con marcadores de adiposidad en adultos chilenos.

Material y métodos:
Se incluyeron 409 participantes en este estudio transversal. La asociación entre el genotipo FTO (rs9939609) y los marcadores de adiposidad se determinó mediante análisis de regresión lineal. Los marcadores de adiposidad incluidos fueron: peso corporal, índice de masa corporal, masa grasa, circunferencia de la cintura, circunferencia de la cadera y relación cintura/cadera.

Resultados:
Un modelo totalmente ajustado mostró una asociación significativa entre el genotipo FTO y el peso corporal (2,16 kg por cada copia adicional del alelo de riesgo[intervalos de confianza[IC] del 95%: 0,45 a 3,87], p = 0,014), el índice de masa corporal (0,61 kg.m-2[IC del 95%: 0,12 a 1,20], p = 0,050) y la masa grasa (1,14%[IC del 95%: 0,39 a 1,89], p = 0,010). La mayor magnitud de asociación se encontró entre el gen FTO y la masa grasa cuando los resultados se estandarizaron a z-score.

Conclusiones:
Este estudio confirma una asociación entre el gen FTO y los marcadores de adiposidad en adultos chilenos, que es independiente de los principales factores de confusión.
Título traducido de la contribuciónAsociación entre el genotipo FTO (ns9939609) y los marcadores de adiposidad en adultos chilenos
IdiomaEnglish (US)
Páginas717-726
Número de páginas10
PublicaciónRevista Medica de Chile
Volumen146
Número de edición6
DOI
EstadoPublished - jun 1 2018

Citar esto

Petermann, F., Villagrán, M., Troncoso, C., Mardones, L., Leiva, A. M., Martínez, M. A., ... Celis-Morales, C. (2018). Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults. Revista Medica de Chile, 146(6), 717-726. https://doi.org/10.4067/s0034-98872018000600717
Petermann, Fanny ; Villagrán, Marcelo ; Troncoso, Claudia ; Mardones, Lorena ; Leiva, Ana María ; Martínez, María Adela ; Garrido-Méndez, Alex ; Poblete-Valderrama, Felipe ; Salas-Bravo, Carlos ; Ramírez-Vélez, Robinson ; Ulloa, Natalia ; Pérez-Bravo, Francisco ; Celis-Morales, Carlos. / Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults. En: Revista Medica de Chile. 2018 ; Vol. 146, N.º 6. pp. 717-726.
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title = "Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults",
abstract = "{\circledC} 2018, Sociedad Medica de Santiago. All rights reserved. Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95{\%} confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2[95{\%} CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14{\%} [95{\%} CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.",
author = "Fanny Petermann and Marcelo Villagr{\'a}n and Claudia Troncoso and Lorena Mardones and Leiva, {Ana Mar{\'i}a} and Mart{\'i}nez, {Mar{\'i}a Adela} and Alex Garrido-M{\'e}ndez and Felipe Poblete-Valderrama and Carlos Salas-Bravo and Robinson Ram{\'i}rez-V{\'e}lez and Natalia Ulloa and Francisco P{\'e}rez-Bravo and Carlos Celis-Morales",
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Petermann, F, Villagrán, M, Troncoso, C, Mardones, L, Leiva, AM, Martínez, MA, Garrido-Méndez, A, Poblete-Valderrama, F, Salas-Bravo, C, Ramírez-Vélez, R, Ulloa, N, Pérez-Bravo, F & Celis-Morales, C 2018, 'Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults' Revista Medica de Chile, vol. 146, n.º 6, pp. 717-726. https://doi.org/10.4067/s0034-98872018000600717

Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults. / Petermann, Fanny; Villagrán, Marcelo; Troncoso, Claudia; Mardones, Lorena; Leiva, Ana María; Martínez, María Adela; Garrido-Méndez, Alex; Poblete-Valderrama, Felipe; Salas-Bravo, Carlos; Ramírez-Vélez, Robinson; Ulloa, Natalia; Pérez-Bravo, Francisco; Celis-Morales, Carlos.

En: Revista Medica de Chile, Vol. 146, N.º 6, 01.06.2018, p. 717-726.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults

AU - Petermann, Fanny

AU - Villagrán, Marcelo

AU - Troncoso, Claudia

AU - Mardones, Lorena

AU - Leiva, Ana María

AU - Martínez, María Adela

AU - Garrido-Méndez, Alex

AU - Poblete-Valderrama, Felipe

AU - Salas-Bravo, Carlos

AU - Ramírez-Vélez, Robinson

AU - Ulloa, Natalia

AU - Pérez-Bravo, Francisco

AU - Celis-Morales, Carlos

PY - 2018/6/1

Y1 - 2018/6/1

N2 - © 2018, Sociedad Medica de Santiago. All rights reserved. Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2[95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.

AB - © 2018, Sociedad Medica de Santiago. All rights reserved. Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2[95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.

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Petermann F, Villagrán M, Troncoso C, Mardones L, Leiva AM, Martínez MA y otros. Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults. Revista Medica de Chile. 2018 jun 1;146(6):717-726. https://doi.org/10.4067/s0034-98872018000600717