Arthritis associated with primary agammaglobulinemia: New clues to its immunopathology

J. Sany, C. Jorgensen, J. M. Anaya, C. Didry, M. Andary, I. Serre, P. Baldet

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

17 Citas (Scopus)

Resumen

Primary agammaglobulinemia is a rare disorder which is associated with articular symptoms in 11% of patients. Septic arthritis may occur, but often patients complain of chronic oligoarthritis and have a clinical presentation similar to rheumatoid arthritis. We report 2 cases of primary agammaglobulinemia in adults, associated with non-erosive chronic arthritis. Peripheral blood lymphocyte phenotyping showed a predominance of CD8 lymphocytes with a CD4/CD8 ratio <1. We did not find any abnormalities in cellular immunity. A histological study of the synovium showed chronic synovitis with perivascular CD8 lymphocyte infiltrates. Intravenous infusion of immunoglobulins resulted in a dramatic improvement in the arthritis in both cases. In one patient we noticed a decrease in CD8 lymphocytosis. These results suggest that CD8 lymphocytes are involved in the pathogenesis of the arthritis associated with agammaglobulinemia.

Idioma originalInglés estadounidense
Páginas (desde-hasta)65-69
Número de páginas5
PublicaciónClinical and Experimental Rheumatology
Volumen11
N.º1
EstadoPublicada - 1993
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Reumatología
  • Inmulogía y alergología
  • Inmunología

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