Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically Important Candida Species

Gina P Rodríguez-Castaño; Frank Rosenau; Ludger Ständker; Carolina Firacative

doi:10.3390/pharmaceutics15030789

Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically Important Candida Species

Gina P Rodríguez-Castaño
, Frank Rosenau
, Ludger Ständker
, Carolina Firacative

Producción científica: Contribución a revista › Artículo de revisión › revisión exhaustiva

25 Citas (Scopus)

Resumen

Ampliar el arsenal de fármacos antifúngicos para tratar las infecciones por Candida es crucial en esta época de aumento de la esperanza de vida de los pacientes con inmunodepresión y comorbilidades. Las infecciones causadas por especies de Candida van en aumento, incluidas las causadas por cepas o especies multirresistentes, y la lista de antifúngicos aprobados para el tratamiento de estas infecciones sigue siendo limitada. Los péptidos antimicrobianos (AMP) son polipéptidos catiónicos cortos cuya actividad antimicrobiana está siendo objeto de intensa investigación. En esta revisión, presentamos un resumen exhaustivo de los AMP con actividad anti-Candida que han sido sometidos con éxito a ensayos preclínicos o clínicos. Se presenta su origen, modo de acción y modelo animal de infección (o ensayo clínico). Además, dado que algunos de estos AMP se han probado en terapia combinada, se describen las ventajas de este enfoque, así como los casos estudiados en los que se han utilizado AMP y otros fármacos de forma concomitante para combatir las infecciones por Candida.

Idioma original	Inglés estadounidense
Publicación	Pharmaceutics
Volumen	15
N.º	3
DOI	https://doi.org/10.3390/pharmaceutics15030789
Estado	Publicada - feb. 27 2023

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@article{00913c3cd6d94cc2912ca7a40240ff9d,

title = "Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically Important Candida Species",

abstract = "Expanding the antifungal drug arsenal for treating Candida infections is crucial in this era of the rising life expectancy of patients with immunosuppression and comorbidities. Infections caused by Candida species are on the rise, including those caused by multidrug-resistant strains or species, and the list of antifungals approved for the treatment of these infections is still limited. Antimicrobial peptides (AMPs) are short cationic polypeptides whose antimicrobial activity is under intense investigation. In this review, we present a comprehensive summary of the AMPs with anti-Candida activity that have undergone successful preclinical or clinical trials. Their source, mode of action, and animal model of infection (or clinical trial) are presented. In addition, as some of these AMPs have been tested in combination therapy, the advantages of this approach, as well as the studied cases that have used AMPs and other drugs concomitantly to fight Candida infections, are described.",

author = "Rodr{\'i}guez-Casta{\~n}o, \{Gina P\} and Frank Rosenau and Ludger St{\"a}ndker and Carolina Firacative",

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doi = "10.3390/pharmaceutics15030789",

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T1 - Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically Important Candida Species

AU - Rodríguez-Castaño, Gina P

AU - Rosenau, Frank

AU - Ständker, Ludger

AU - Firacative, Carolina

PY - 2023/2/27

Y1 - 2023/2/27

N2 - Expanding the antifungal drug arsenal for treating Candida infections is crucial in this era of the rising life expectancy of patients with immunosuppression and comorbidities. Infections caused by Candida species are on the rise, including those caused by multidrug-resistant strains or species, and the list of antifungals approved for the treatment of these infections is still limited. Antimicrobial peptides (AMPs) are short cationic polypeptides whose antimicrobial activity is under intense investigation. In this review, we present a comprehensive summary of the AMPs with anti-Candida activity that have undergone successful preclinical or clinical trials. Their source, mode of action, and animal model of infection (or clinical trial) are presented. In addition, as some of these AMPs have been tested in combination therapy, the advantages of this approach, as well as the studied cases that have used AMPs and other drugs concomitantly to fight Candida infections, are described.

AB - Expanding the antifungal drug arsenal for treating Candida infections is crucial in this era of the rising life expectancy of patients with immunosuppression and comorbidities. Infections caused by Candida species are on the rise, including those caused by multidrug-resistant strains or species, and the list of antifungals approved for the treatment of these infections is still limited. Antimicrobial peptides (AMPs) are short cationic polypeptides whose antimicrobial activity is under intense investigation. In this review, we present a comprehensive summary of the AMPs with anti-Candida activity that have undergone successful preclinical or clinical trials. Their source, mode of action, and animal model of infection (or clinical trial) are presented. In addition, as some of these AMPs have been tested in combination therapy, the advantages of this approach, as well as the studied cases that have used AMPs and other drugs concomitantly to fight Candida infections, are described.

U2 - 10.3390/pharmaceutics15030789

DO - 10.3390/pharmaceutics15030789

M3 - Review article

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SN - 1999-4923

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JO - Pharmaceutics

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ER -

Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically Important Candida Species

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