Antifungal susceptibility of clinical Cryptococcus gattii isolates from Colombia varies among molecular types

Carolina Firacative, Patricia Escandón

Producción científica: Contribución a una revistaArtículo de Investigaciónrevisión exhaustiva

5 Citas (Scopus)

Resumen

Cryptococcosis by Cryptococcus gattii is endemic in Colombia, affecting mostly immunocompetent hosts. Since antifungal susceptibility differs between molecular types of cryptococcal isolates, as reported elsewhere, the aim of this study was to determine if 42 Colombian clinical isolates, VGI, VGII and VGIII, differ in the susceptibility to commonly used antifungals, using Sensititre plates. Among the molecular types, six non-wild type isolates to fluconazole, voriconazole and 5-flucytosine, were identified. Besides, VGI and VGII were less susceptible to 5-flucytosine and azoles, respectively, than other molecular types. These findings support the applicability of practicing susceptibility testing, which could better guide treatment in cryptococcosis.

Idioma originalInglés estadounidense
Páginas (desde-hasta)1122
Número de páginas1125
PublicaciónMedical Mycology
Volumen59
N.º11
Fecha en línea anticipadajul. 15 2021
DOI
EstadoPublicada - nov. 2021
EventoCongress on Trends in Medical Mycology - Aberdeen, Reino Unido
Duración: oct. 8 2021oct. 11 2021
Número de conferencia: 10th
https://www.timm2021.org/

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