Antibiotic treatment for ocular toxoplasmosis: A systematic review and meta-analysis: Study protocol

John E. Feliciano-Alfonso, Andrés Vargas-Villanueva, María Alejandra Marín, Laura Triviño, Natalia Carvajal, Manuela Moreno, Tatiana Luna, Clara Lopez De Mesa, Juliana Muñoz-Ortiz, Alejandra De-La-Torre

Resultado de la investigación: Contribución a RevistaArtículo de revisión

Resumen

Background: Ocular toxoplasmosis (OT) is the most common cause of posterior uveitis, leading to visual impairment in a high proportion of patients. Antibiotics and corticosteroids lower the risk of permanent visual impairment by reducing the size of the retinochoroidal scar, the risk of recurrence, and the severity and duration of acute symptoms. Although OT is a very common cause of infectious posterior uveitis, its treatment remains controversial. Through our systematic review and meta-analysis, we aim to provide the best possible evidence-based information on the safety and effectiveness of the different antibiotic regimes for OT. Methods: This systematic review protocol has been developed based on PRISMA-P guidelines for reporting systematic reviews evaluating health care interventions. We will include all published and unpublished randomized controlled trials (RCTs) comparing different antibiotics used for the treatment of OT. We will consider changes in visual acuity, number of recurrences, improvement or worsening of ocular inflammation, size of lesion, and adverse effects as our outcomes. Screening, data extraction, and quality assessment will be undertaken by two reviewers with disagreements resolved through discussion. Studies that compared antibiotics with placebo will be excluded. The reviews will be assessed for quality and relevance. We will assess the risk of bias in five domains according to Cochrane group's tool. The type of data will dictate measures of treatment effect. We will use a random-effects model to calculate our meta-analysis, as eligible studies represent clinically varied populations of participants. Discussion: The strength of our study will lie in the exhaustive and systematic nature of the literature search, as well as in its methods for assessing quality and analyzing RCT data. Considering the controversial efficacy of the treatment for OT, our study will contribute to improving the existing evidence on the effectiveness of different antibiotics. Future studies may be conducted to increase physicians' awareness of antibiotic therapies, improving the health of patients with OT. Systematic review registration: PROSPERO CRD42018085468.

Idioma originalEnglish (US)
Número de artículo146
PublicaciónSystematic Reviews
Volumen8
N.º1
DOI
EstadoPublished - jun 20 2019
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)

Citar esto

Feliciano-Alfonso, J. E., Vargas-Villanueva, A., Marín, M. A., Triviño, L., Carvajal, N., Moreno, M., ... De-La-Torre, A. (2019). Antibiotic treatment for ocular toxoplasmosis: A systematic review and meta-analysis: Study protocol. Systematic Reviews, 8(1), [146]. https://doi.org/10.1186/s13643-019-1067-8
Feliciano-Alfonso, John E. ; Vargas-Villanueva, Andrés ; Marín, María Alejandra ; Triviño, Laura ; Carvajal, Natalia ; Moreno, Manuela ; Luna, Tatiana ; Lopez De Mesa, Clara ; Muñoz-Ortiz, Juliana ; De-La-Torre, Alejandra. / Antibiotic treatment for ocular toxoplasmosis : A systematic review and meta-analysis: Study protocol. En: Systematic Reviews. 2019 ; Vol. 8, N.º 1.
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title = "Antibiotic treatment for ocular toxoplasmosis: A systematic review and meta-analysis: Study protocol",
abstract = "Background: Ocular toxoplasmosis (OT) is the most common cause of posterior uveitis, leading to visual impairment in a high proportion of patients. Antibiotics and corticosteroids lower the risk of permanent visual impairment by reducing the size of the retinochoroidal scar, the risk of recurrence, and the severity and duration of acute symptoms. Although OT is a very common cause of infectious posterior uveitis, its treatment remains controversial. Through our systematic review and meta-analysis, we aim to provide the best possible evidence-based information on the safety and effectiveness of the different antibiotic regimes for OT. Methods: This systematic review protocol has been developed based on PRISMA-P guidelines for reporting systematic reviews evaluating health care interventions. We will include all published and unpublished randomized controlled trials (RCTs) comparing different antibiotics used for the treatment of OT. We will consider changes in visual acuity, number of recurrences, improvement or worsening of ocular inflammation, size of lesion, and adverse effects as our outcomes. Screening, data extraction, and quality assessment will be undertaken by two reviewers with disagreements resolved through discussion. Studies that compared antibiotics with placebo will be excluded. The reviews will be assessed for quality and relevance. We will assess the risk of bias in five domains according to Cochrane group's tool. The type of data will dictate measures of treatment effect. We will use a random-effects model to calculate our meta-analysis, as eligible studies represent clinically varied populations of participants. Discussion: The strength of our study will lie in the exhaustive and systematic nature of the literature search, as well as in its methods for assessing quality and analyzing RCT data. Considering the controversial efficacy of the treatment for OT, our study will contribute to improving the existing evidence on the effectiveness of different antibiotics. Future studies may be conducted to increase physicians' awareness of antibiotic therapies, improving the health of patients with OT. Systematic review registration: PROSPERO CRD42018085468.",
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Feliciano-Alfonso, JE, Vargas-Villanueva, A, Marín, MA, Triviño, L, Carvajal, N, Moreno, M, Luna, T, Lopez De Mesa, C, Muñoz-Ortiz, J & De-La-Torre, A 2019, 'Antibiotic treatment for ocular toxoplasmosis: A systematic review and meta-analysis: Study protocol', Systematic Reviews, vol. 8, n.º 1, 146. https://doi.org/10.1186/s13643-019-1067-8

Antibiotic treatment for ocular toxoplasmosis : A systematic review and meta-analysis: Study protocol. / Feliciano-Alfonso, John E.; Vargas-Villanueva, Andrés; Marín, María Alejandra; Triviño, Laura; Carvajal, Natalia; Moreno, Manuela; Luna, Tatiana; Lopez De Mesa, Clara; Muñoz-Ortiz, Juliana; De-La-Torre, Alejandra.

En: Systematic Reviews, Vol. 8, N.º 1, 146, 20.06.2019.

Resultado de la investigación: Contribución a RevistaArtículo de revisión

TY - JOUR

T1 - Antibiotic treatment for ocular toxoplasmosis

T2 - A systematic review and meta-analysis: Study protocol

AU - Feliciano-Alfonso, John E.

AU - Vargas-Villanueva, Andrés

AU - Marín, María Alejandra

AU - Triviño, Laura

AU - Carvajal, Natalia

AU - Moreno, Manuela

AU - Luna, Tatiana

AU - Lopez De Mesa, Clara

AU - Muñoz-Ortiz, Juliana

AU - De-La-Torre, Alejandra

PY - 2019/6/20

Y1 - 2019/6/20

N2 - Background: Ocular toxoplasmosis (OT) is the most common cause of posterior uveitis, leading to visual impairment in a high proportion of patients. Antibiotics and corticosteroids lower the risk of permanent visual impairment by reducing the size of the retinochoroidal scar, the risk of recurrence, and the severity and duration of acute symptoms. Although OT is a very common cause of infectious posterior uveitis, its treatment remains controversial. Through our systematic review and meta-analysis, we aim to provide the best possible evidence-based information on the safety and effectiveness of the different antibiotic regimes for OT. Methods: This systematic review protocol has been developed based on PRISMA-P guidelines for reporting systematic reviews evaluating health care interventions. We will include all published and unpublished randomized controlled trials (RCTs) comparing different antibiotics used for the treatment of OT. We will consider changes in visual acuity, number of recurrences, improvement or worsening of ocular inflammation, size of lesion, and adverse effects as our outcomes. Screening, data extraction, and quality assessment will be undertaken by two reviewers with disagreements resolved through discussion. Studies that compared antibiotics with placebo will be excluded. The reviews will be assessed for quality and relevance. We will assess the risk of bias in five domains according to Cochrane group's tool. The type of data will dictate measures of treatment effect. We will use a random-effects model to calculate our meta-analysis, as eligible studies represent clinically varied populations of participants. Discussion: The strength of our study will lie in the exhaustive and systematic nature of the literature search, as well as in its methods for assessing quality and analyzing RCT data. Considering the controversial efficacy of the treatment for OT, our study will contribute to improving the existing evidence on the effectiveness of different antibiotics. Future studies may be conducted to increase physicians' awareness of antibiotic therapies, improving the health of patients with OT. Systematic review registration: PROSPERO CRD42018085468.

AB - Background: Ocular toxoplasmosis (OT) is the most common cause of posterior uveitis, leading to visual impairment in a high proportion of patients. Antibiotics and corticosteroids lower the risk of permanent visual impairment by reducing the size of the retinochoroidal scar, the risk of recurrence, and the severity and duration of acute symptoms. Although OT is a very common cause of infectious posterior uveitis, its treatment remains controversial. Through our systematic review and meta-analysis, we aim to provide the best possible evidence-based information on the safety and effectiveness of the different antibiotic regimes for OT. Methods: This systematic review protocol has been developed based on PRISMA-P guidelines for reporting systematic reviews evaluating health care interventions. We will include all published and unpublished randomized controlled trials (RCTs) comparing different antibiotics used for the treatment of OT. We will consider changes in visual acuity, number of recurrences, improvement or worsening of ocular inflammation, size of lesion, and adverse effects as our outcomes. Screening, data extraction, and quality assessment will be undertaken by two reviewers with disagreements resolved through discussion. Studies that compared antibiotics with placebo will be excluded. The reviews will be assessed for quality and relevance. We will assess the risk of bias in five domains according to Cochrane group's tool. The type of data will dictate measures of treatment effect. We will use a random-effects model to calculate our meta-analysis, as eligible studies represent clinically varied populations of participants. Discussion: The strength of our study will lie in the exhaustive and systematic nature of the literature search, as well as in its methods for assessing quality and analyzing RCT data. Considering the controversial efficacy of the treatment for OT, our study will contribute to improving the existing evidence on the effectiveness of different antibiotics. Future studies may be conducted to increase physicians' awareness of antibiotic therapies, improving the health of patients with OT. Systematic review registration: PROSPERO CRD42018085468.

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U2 - 10.1186/s13643-019-1067-8

DO - 10.1186/s13643-019-1067-8

M3 - Review article

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VL - 8

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Feliciano-Alfonso JE, Vargas-Villanueva A, Marín MA, Triviño L, Carvajal N, Moreno M y otros. Antibiotic treatment for ocular toxoplasmosis: A systematic review and meta-analysis: Study protocol. Systematic Reviews. 2019 jun 20;8(1). 146. https://doi.org/10.1186/s13643-019-1067-8