Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family members

Ilan Krause, Juan Manuel Anaya, Abigail Fraser, Ori Barzilai, Maya Ram, Verónica Abad, Alvaro Arango, Jorge García, Yehuda Shoenfeld

Resultado de la investigación: Capítulo en Libro/Reporte/ConferenciaContribución a la conferencia

34 Citas (Scopus)

Resumen

Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune-associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P = 0.01), cytomegalovirus (P = 0.001), Epstein-Barr virus (P = 0.02) and Toxoplasma (P = 0.001). T1DM patients had significantly higher levels of IgG-anti-gliadin antibodies (P = 0.001) and IgG-antitissue transglutaminase antibodies (P = 0.03), and a borderline association with anticentromere antibodies (P = 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies.

Idioma originalInglés estadounidense
Título de la publicación alojadaContemporary Challenges in Autoimmunity
EditorialBlackwell Publishing, Inc.
Páginas633-639
Número de páginas7
ISBN (versión impresa)9781573317627
DOI
EstadoPublicada - sep 2009

Serie de la publicación

NombreAnnals of the New York Academy of Sciences
Volumen1173
ISSN (versión impresa)0077-8923
ISSN (versión digital)1749-6632

All Science Journal Classification (ASJC) codes

  • Neurociencia (todo)
  • Bioquímica, genética y biología molecular (todo)
  • Historia y filosofía de la ciencia

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