Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis

Francisco J. Diaz, Adriana Rojas-Villarraga, Juan C. Salazar, Antonio Iglesias-Gamarra, Ruben D. Mantilla, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaArtículo

12 Citas (Scopus)

Resumen

Objectives: To determine factors influencing the age at onset of rheumatoid arthritis (RA). Methods: A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors on the age at RA onset were computed by using Cox regression models. Results: Positive anti-CCP antibodies were associated with an increased risk of early RA onset (HR=1.60; 95% confidence interval, [1.06, 2.4]), whereas the presence of the protective 70DERAA74 sequence was associated with a delayed onset (HR=0.55; [0.33, 0.92]). After controlling for both anti-CCP antibodies and the 70DERAA74 sequence, the following variables did not influence significantly the age at RA onset: gender, ever cigarette smoking, family RA history, the TNF-308 A polymorphism, HLA shared epitope, and the presence of rheumatoid factor. Conclusion: Anti-CCP antibodies and the HLA-DRB1 70DERAA74 sequence influence the age at onset of RA. © 2010 Société française de rhumatologie.
Idioma originalEnglish (US)
Páginas (desde-hasta)175-178
Número de páginas4
PublicaciónJoint Bone Spine
DOI
EstadoPublished - mar 1 2011

Huella dactilar

Age of Onset
Anti-Idiotypic Antibodies
Rheumatoid Arthritis
HLA-DRB1 Chains
Rheumatoid Factor
Proportional Hazards Models
Epitopes
Smoking
Confidence Intervals

Citar esto

Diaz, F. J., Rojas-Villarraga, A., Salazar, J. C., Iglesias-Gamarra, A., Mantilla, R. D., & Anaya, J. M. (2011). Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis. Joint Bone Spine, 175-178. https://doi.org/10.1016/j.jbspin.2010.07.014
Diaz, Francisco J. ; Rojas-Villarraga, Adriana ; Salazar, Juan C. ; Iglesias-Gamarra, Antonio ; Mantilla, Ruben D. ; Anaya, Juan Manuel. / Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis. En: Joint Bone Spine. 2011 ; pp. 175-178.
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abstract = "Objectives: To determine factors influencing the age at onset of rheumatoid arthritis (RA). Methods: A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors on the age at RA onset were computed by using Cox regression models. Results: Positive anti-CCP antibodies were associated with an increased risk of early RA onset (HR=1.60; 95{\%} confidence interval, [1.06, 2.4]), whereas the presence of the protective 70DERAA74 sequence was associated with a delayed onset (HR=0.55; [0.33, 0.92]). After controlling for both anti-CCP antibodies and the 70DERAA74 sequence, the following variables did not influence significantly the age at RA onset: gender, ever cigarette smoking, family RA history, the TNF-308 A polymorphism, HLA shared epitope, and the presence of rheumatoid factor. Conclusion: Anti-CCP antibodies and the HLA-DRB1 70DERAA74 sequence influence the age at onset of RA. {\circledC} 2010 Soci{\'e}t{\'e} fran{\cc}aise de rhumatologie.",
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Diaz, FJ, Rojas-Villarraga, A, Salazar, JC, Iglesias-Gamarra, A, Mantilla, RD & Anaya, JM 2011, 'Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis', Joint Bone Spine, pp. 175-178. https://doi.org/10.1016/j.jbspin.2010.07.014

Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis. / Diaz, Francisco J.; Rojas-Villarraga, Adriana; Salazar, Juan C.; Iglesias-Gamarra, Antonio; Mantilla, Ruben D.; Anaya, Juan Manuel.

En: Joint Bone Spine, 01.03.2011, p. 175-178.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis

AU - Diaz, Francisco J.

AU - Rojas-Villarraga, Adriana

AU - Salazar, Juan C.

AU - Iglesias-Gamarra, Antonio

AU - Mantilla, Ruben D.

AU - Anaya, Juan Manuel

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Objectives: To determine factors influencing the age at onset of rheumatoid arthritis (RA). Methods: A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors on the age at RA onset were computed by using Cox regression models. Results: Positive anti-CCP antibodies were associated with an increased risk of early RA onset (HR=1.60; 95% confidence interval, [1.06, 2.4]), whereas the presence of the protective 70DERAA74 sequence was associated with a delayed onset (HR=0.55; [0.33, 0.92]). After controlling for both anti-CCP antibodies and the 70DERAA74 sequence, the following variables did not influence significantly the age at RA onset: gender, ever cigarette smoking, family RA history, the TNF-308 A polymorphism, HLA shared epitope, and the presence of rheumatoid factor. Conclusion: Anti-CCP antibodies and the HLA-DRB1 70DERAA74 sequence influence the age at onset of RA. © 2010 Société française de rhumatologie.

AB - Objectives: To determine factors influencing the age at onset of rheumatoid arthritis (RA). Methods: A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors on the age at RA onset were computed by using Cox regression models. Results: Positive anti-CCP antibodies were associated with an increased risk of early RA onset (HR=1.60; 95% confidence interval, [1.06, 2.4]), whereas the presence of the protective 70DERAA74 sequence was associated with a delayed onset (HR=0.55; [0.33, 0.92]). After controlling for both anti-CCP antibodies and the 70DERAA74 sequence, the following variables did not influence significantly the age at RA onset: gender, ever cigarette smoking, family RA history, the TNF-308 A polymorphism, HLA shared epitope, and the presence of rheumatoid factor. Conclusion: Anti-CCP antibodies and the HLA-DRB1 70DERAA74 sequence influence the age at onset of RA. © 2010 Société française de rhumatologie.

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Diaz FJ, Rojas-Villarraga A, Salazar JC, Iglesias-Gamarra A, Mantilla RD, Anaya JM. Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis. Joint Bone Spine. 2011 mar 1;175-178. https://doi.org/10.1016/j.jbspin.2010.07.014