Anatomical and functional outcomes of symptomatic idiopathic vitreomacular traction

Lihteh Wu; Marcelo Zas; Maria H. Berrocal; J. Fernando Arevalo; Marta Figueroa; Francisco Rodriguez; Martin Serrano; Federico Graue; Arturo Alezzandrini; Roberto Gallego-Pinazo; José A. Roca; Matias Iglicki; José Dalma-Weishauz; Igor Kozak; Alberto Collado; Josep Badal; Mauricio Maia; Guillermo Salcedo-Villanueva; Hugo Quiroz-Mercado; Jans Fromow-Guerra; David Lozano-Rechy; Marcos Avila; Jay Chhablani

doi:10.1097/IAE.0000000000001015

Anatomical and functional outcomes of symptomatic idiopathic vitreomacular traction

Título traducido de la contribución: A Natural History Study From the Pan American Collaborative Retina Study Group

Lihteh Wu
, Marcelo Zas
, Maria H. Berrocal
, J. Fernando Arevalo
, Marta Figueroa
, Francisco Rodriguez
, Martin Serrano
, Federico Graue
, Arturo Alezzandrini
, Roberto Gallego-Pinazo
, José A. Roca
, Matias Iglicki
, José Dalma-Weishauz
, Igor Kozak
, Alberto Collado
, Josep Badal
, Mauricio Maia
, Guillermo Salcedo-Villanueva
, Hugo Quiroz-Mercado
, Jans Fromow-Guerra

David Lozano-Rechy, Marcos Avila, Jay Chhablani

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

28 Citas (Scopus)

Resumen

Purpose:
To describe the natural history of eyes with symptomatic idiopathic vitreomacular traction (VMT).

Methods:
Retrospective multicenter study of 168 eyes with spectral-domain optical coherence tomography (SD-OCT) findings consistent with idiopathic VMT. All eyes were graded according to SD-OCT findings. Grade 1 was defined as incomplete cortical vitreous separation with foveal attachment. Grade 2 was defined as Grade 1 plus intraretinal cysts or clefts. Grade 3 was defined as Grade 2 plus a foveal detachment. All patients were followed for at least 6 months.

Results:
There were 168 patients (51 men) with a mean age of 68.8 ± 10.7 years. Patients were followed for a mean of 22.7 ± 20.1 months. The mean duration of symptoms before the initial presentation was 3.65 ± 5.42 months. At baseline, 72 eyes had Grade 1, 74 eyes had Grade 2, and 22 eyes had Grade 3 SD-OCT findings. Over the follow-up period, 36 eyes (21.4%) had spontaneous resolution of the VMT with normalization of the foveal anatomy. The mean time to resolution was 12.3 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7% (13 of 168) of the eyes, with 6 eyes developing a lamellar macular hole and 7 eyes developing a full-thickness macular hole. This occurred at a mean of 10.3 ± 10.7 months after the presentation. Subgroup analysis based on baseline SD-OCT grade showed that 4.1% (3 of 73) of Grade 1 eyes compared with 6.8% (5 of 74) of Grade 2 eyes, and 23.8% (5 of 21) of Grade 3 eyes developed a full-thickness macular hole or lamellar macular hole (P = 0.0109, chi-square test). In the remaining 119 eyes, at the last follow-up, 65 eyes had Grade 1, 42 eyes had Grade 2, and 12 eyes had Grade 3 VMT. On average, the best-corrected visual acuity improved from 0.40 ± 0.35 logarithm of the minimum angle of resolution (Snellen, 20/50) at baseline to 0.35 ± 0.36 logarithm of the minimum angle of resolution (Snellen, 20/45; P = 0.0372), and the mean central macular thickness improved from 350 ± 132 μm to 323 ± 121 μm.

Conclusion:
Spontaneous resolution of VMT occurred in 21.4% (36 of 168) of eyes after a mean follow-up of 11.4 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7% (13 of 168) of eyes. The baseline SD-OCT grade may predict the progression to full-thickness macular hole.

Título traducido de la contribución	A Natural History Study From the Pan American Collaborative Retina Study Group
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	1913-1918
Número de páginas	6
Publicación	Retina
Volumen	36
N.º	10
DOI	https://doi.org/10.1097/IAE.0000000000001015
Estado	Publicada - oct. 1 2016

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Oftalmología

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Wu, L., Zas, M., Berrocal, M. H., Arevalo, J. F., Figueroa, M., Rodriguez, F., Serrano, M., Graue, F., Alezzandrini, A., Gallego-Pinazo, R., Roca, J. A., Iglicki, M., Dalma-Weishauz, J., Kozak, I., Collado, A., Badal, J., Maia, M., Salcedo-Villanueva, G., Quiroz-Mercado, H., ... Chhablani, J. (2016). Anatomical and functional outcomes of symptomatic idiopathic vitreomacular traction. Retina, 36(10), 1913-1918. https://doi.org/10.1097/IAE.0000000000001015

@article{74deff1cac9f433684e29767ffb2f58a,

title = "Anatomical and functional outcomes of symptomatic idiopathic vitreomacular traction",

abstract = "Purpose: To describe the natural history of eyes with symptomatic idiopathic vitreomacular traction (VMT). Methods: Retrospective multicenter study of 168 eyes with spectral-domain optical coherence tomography (SD-OCT) findings consistent with idiopathic VMT. All eyes were graded according to SD-OCT findings. Grade 1 was defined as incomplete cortical vitreous separation with foveal attachment. Grade 2 was defined as Grade 1 plus intraretinal cysts or clefts. Grade 3 was defined as Grade 2 plus a foveal detachment. All patients were followed for at least 6 months. Results: There were 168 patients (51 men) with a mean age of 68.8 ± 10.7 years. Patients were followed for a mean of 22.7 ± 20.1 months. The mean duration of symptoms before the initial presentation was 3.65 ± 5.42 months. At baseline, 72 eyes had Grade 1, 74 eyes had Grade 2, and 22 eyes had Grade 3 SD-OCT findings. Over the follow-up period, 36 eyes (21.4\%) had spontaneous resolution of the VMT with normalization of the foveal anatomy. The mean time to resolution was 12.3 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7\% (13 of 168) of the eyes, with 6 eyes developing a lamellar macular hole and 7 eyes developing a full-thickness macular hole. This occurred at a mean of 10.3 ± 10.7 months after the presentation. Subgroup analysis based on baseline SD-OCT grade showed that 4.1\% (3 of 73) of Grade 1 eyes compared with 6.8\% (5 of 74) of Grade 2 eyes, and 23.8\% (5 of 21) of Grade 3 eyes developed a full-thickness macular hole or lamellar macular hole (P 0.0109, chi-square test). In the remaining 119 eyes, at the last follow-up, 65 eyes had Grade 1, 42 eyes had Grade 2, and 12 eyes had Grade 3 VMT. On average, the best-corrected visual acuity improved from 0.40 ± 0.35 logarithm of the minimum angle of resolution (Snellen, 20/50) at baseline to 0.35 ± 0.36 logarithm of the minimum angle of resolution (Snellen, 20/45; P 0.0372), and the mean central macular thickness improved from 350 ± 132 m to 323 ± 121 m. Conclusion: Spontaneous resolution of VMT occurred in 21.4\% (36 of 168) of eyes after a mean follow-up of 11.4 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7\% (13 of 168) of eyes. The baseline SD-OCT grade may predict the progression to full-thickness macular hole.",

author = "Lihteh Wu and Marcelo Zas and Berrocal, \{Maria H.\} and Arevalo, \{J. Fernando\} and Marta Figueroa and Francisco Rodriguez and Martin Serrano and Federico Graue and Arturo Alezzandrini and Roberto Gallego-Pinazo and Roca, \{Jos{\'e} A.\} and Matias Iglicki and Jos{\'e} Dalma-Weishauz and Igor Kozak and Alberto Collado and Josep Badal and Mauricio Maia and Guillermo Salcedo-Villanueva and Hugo Quiroz-Mercado and Jans Fromow-Guerra and David Lozano-Rechy and Marcos Avila and Jay Chhablani",

year = "2016",

month = oct,

day = "1",

doi = "10.1097/IAE.0000000000001015",

language = "English (US)",

volume = "36",

pages = "1913--1918",

journal = "Retina",

issn = "0275-004X",

publisher = "Lippincott Williams and Wilkins",

number = "10",

}

Wu, L, Zas, M, Berrocal, MH, Arevalo, JF, Figueroa, M, Rodriguez, F, Serrano, M, Graue, F, Alezzandrini, A, Gallego-Pinazo, R, Roca, JA, Iglicki, M, Dalma-Weishauz, J, Kozak, I, Collado, A, Badal, J, Maia, M, Salcedo-Villanueva, G, Quiroz-Mercado, H, Fromow-Guerra, J, Lozano-Rechy, D, Avila, M & Chhablani, J 2016, 'Anatomical and functional outcomes of symptomatic idiopathic vitreomacular traction', Retina, vol. 36, n.º 10, pp. 1913-1918. https://doi.org/10.1097/IAE.0000000000001015

TY - JOUR

T1 - Anatomical and functional outcomes of symptomatic idiopathic vitreomacular traction

AU - Wu, Lihteh

AU - Zas, Marcelo

AU - Berrocal, Maria H.

AU - Arevalo, J. Fernando

AU - Figueroa, Marta

AU - Rodriguez, Francisco

AU - Serrano, Martin

AU - Graue, Federico

AU - Alezzandrini, Arturo

AU - Gallego-Pinazo, Roberto

AU - Roca, José A.

AU - Iglicki, Matias

AU - Dalma-Weishauz, José

AU - Kozak, Igor

AU - Collado, Alberto

AU - Badal, Josep

AU - Maia, Mauricio

AU - Salcedo-Villanueva, Guillermo

AU - Quiroz-Mercado, Hugo

AU - Fromow-Guerra, Jans

AU - Lozano-Rechy, David

AU - Avila, Marcos

AU - Chhablani, Jay

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Purpose: To describe the natural history of eyes with symptomatic idiopathic vitreomacular traction (VMT). Methods: Retrospective multicenter study of 168 eyes with spectral-domain optical coherence tomography (SD-OCT) findings consistent with idiopathic VMT. All eyes were graded according to SD-OCT findings. Grade 1 was defined as incomplete cortical vitreous separation with foveal attachment. Grade 2 was defined as Grade 1 plus intraretinal cysts or clefts. Grade 3 was defined as Grade 2 plus a foveal detachment. All patients were followed for at least 6 months. Results: There were 168 patients (51 men) with a mean age of 68.8 ± 10.7 years. Patients were followed for a mean of 22.7 ± 20.1 months. The mean duration of symptoms before the initial presentation was 3.65 ± 5.42 months. At baseline, 72 eyes had Grade 1, 74 eyes had Grade 2, and 22 eyes had Grade 3 SD-OCT findings. Over the follow-up period, 36 eyes (21.4%) had spontaneous resolution of the VMT with normalization of the foveal anatomy. The mean time to resolution was 12.3 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7% (13 of 168) of the eyes, with 6 eyes developing a lamellar macular hole and 7 eyes developing a full-thickness macular hole. This occurred at a mean of 10.3 ± 10.7 months after the presentation. Subgroup analysis based on baseline SD-OCT grade showed that 4.1% (3 of 73) of Grade 1 eyes compared with 6.8% (5 of 74) of Grade 2 eyes, and 23.8% (5 of 21) of Grade 3 eyes developed a full-thickness macular hole or lamellar macular hole (P 0.0109, chi-square test). In the remaining 119 eyes, at the last follow-up, 65 eyes had Grade 1, 42 eyes had Grade 2, and 12 eyes had Grade 3 VMT. On average, the best-corrected visual acuity improved from 0.40 ± 0.35 logarithm of the minimum angle of resolution (Snellen, 20/50) at baseline to 0.35 ± 0.36 logarithm of the minimum angle of resolution (Snellen, 20/45; P 0.0372), and the mean central macular thickness improved from 350 ± 132 m to 323 ± 121 m. Conclusion: Spontaneous resolution of VMT occurred in 21.4% (36 of 168) of eyes after a mean follow-up of 11.4 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7% (13 of 168) of eyes. The baseline SD-OCT grade may predict the progression to full-thickness macular hole.

AB - Purpose: To describe the natural history of eyes with symptomatic idiopathic vitreomacular traction (VMT). Methods: Retrospective multicenter study of 168 eyes with spectral-domain optical coherence tomography (SD-OCT) findings consistent with idiopathic VMT. All eyes were graded according to SD-OCT findings. Grade 1 was defined as incomplete cortical vitreous separation with foveal attachment. Grade 2 was defined as Grade 1 plus intraretinal cysts or clefts. Grade 3 was defined as Grade 2 plus a foveal detachment. All patients were followed for at least 6 months. Results: There were 168 patients (51 men) with a mean age of 68.8 ± 10.7 years. Patients were followed for a mean of 22.7 ± 20.1 months. The mean duration of symptoms before the initial presentation was 3.65 ± 5.42 months. At baseline, 72 eyes had Grade 1, 74 eyes had Grade 2, and 22 eyes had Grade 3 SD-OCT findings. Over the follow-up period, 36 eyes (21.4%) had spontaneous resolution of the VMT with normalization of the foveal anatomy. The mean time to resolution was 12.3 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7% (13 of 168) of the eyes, with 6 eyes developing a lamellar macular hole and 7 eyes developing a full-thickness macular hole. This occurred at a mean of 10.3 ± 10.7 months after the presentation. Subgroup analysis based on baseline SD-OCT grade showed that 4.1% (3 of 73) of Grade 1 eyes compared with 6.8% (5 of 74) of Grade 2 eyes, and 23.8% (5 of 21) of Grade 3 eyes developed a full-thickness macular hole or lamellar macular hole (P 0.0109, chi-square test). In the remaining 119 eyes, at the last follow-up, 65 eyes had Grade 1, 42 eyes had Grade 2, and 12 eyes had Grade 3 VMT. On average, the best-corrected visual acuity improved from 0.40 ± 0.35 logarithm of the minimum angle of resolution (Snellen, 20/50) at baseline to 0.35 ± 0.36 logarithm of the minimum angle of resolution (Snellen, 20/45; P 0.0372), and the mean central macular thickness improved from 350 ± 132 m to 323 ± 121 m. Conclusion: Spontaneous resolution of VMT occurred in 21.4% (36 of 168) of eyes after a mean follow-up of 11.4 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7% (13 of 168) of eyes. The baseline SD-OCT grade may predict the progression to full-thickness macular hole.

UR - https://www.scopus.com/pages/publications/84962019082

UR - https://www.scopus.com/pages/publications/84962019082#tab=citedBy

U2 - 10.1097/IAE.0000000000001015

DO - 10.1097/IAE.0000000000001015

M3 - Research Article

C2 - 26966868

AN - SCOPUS:84962019082

SN - 0275-004X

VL - 36

SP - 1913

EP - 1918

JO - Retina

JF - Retina

IS - 10

ER -

Anatomical and functional outcomes of symptomatic idiopathic vitreomacular traction

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