Analyzing biological and molecular characteristics and genomic damage induced by exposure to asbestos

Diana Ospina; Victoria Eugenia Villegas; Giovanni Rodríguez-Leguizamón; Milena Rondón-Lagos

doi:10.2147/CMAR.S205723

Analyzing biological and molecular characteristics and genomic damage induced by exposure to asbestos

Título traducido de la contribución: Analizar las características biológicas y moleculares y el daño genómico inducido por la exposición al amianto.

Diana Ospina, Victoria Eugenia Villegas, Giovanni Rodríguez-Leguizamón, Milena Rondón-Lagos

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

16 Citas (Scopus)

Resumen

El amianto es uno de los carcinógenos ocupacionales más importantes. Actualmente, alrededor de 125 millones de personas en todo el mundo están expuestas al asbesto en el lugar de trabajo. Según estimaciones mundiales, al menos 107.000 personas mueren cada año de cáncer de pulmón, mesotelioma y asbestosis como resultado de la exposición ocupacional al asbesto. Actualmente se conoce la alta patogenicidad de este material, estando asociado al desarrollo de enfermedades pulmonares, de las cuales el cáncer de pulmón es la principal causa de muerte por exposición a este mineral. Las enfermedades pulmonares relacionadas con el amianto son un problema clínico común y un importante problema de salud en todo el mundo. Una extensa investigación ha identificado muchos mecanismos patogénicos importantes; sin embargo, los mecanismos moleculares precisos involucrados y el daño genómico generado que conducen al desarrollo de estas enfermedades no se comprenden completamente. Los modos de acción que subyacen a este tipo de enfermedad parecen diferir según el tipo de fibra, el aclaramiento pulmonar y la genética. Esto evidencia la necesidad de incrementar nuestro conocimiento sobre estos efectos sobre la salud humana. Esta revisión se centra en las características del amianto y el daño celular y genómico que se genera en los seres humanos a través de la exposición.

Título traducido de la contribución	Analizar las características biológicas y moleculares y el daño genómico inducido por la exposición al amianto.
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	4997-5012
Número de páginas	16
Publicación	Cancer Management and Research
Volumen	11
DOI	https://doi.org/10.2147/CMAR.S205723
Estado	Publicada - 2019

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@article{05739c74e90c4d729e7f9e0fa051f80b,

title = "Analyzing biological and molecular characteristics and genomic damage induced by exposure to asbestos",

abstract = "Asbestos is one of the most important occupational carcinogens. Currently, about 125 million people worldwide are exposed to asbestos in the workplace. According to global estimates, at least 107,000 people die each year from lung cancer, mesothelioma, and asbestosis as a result of occupational exposure to asbestos. The high pathogenicity of this material is currently known, being associated with the development of pulmonary diseases, of which lung cancer is the main cause of death due to exposure to this mineral. Pulmonary diseases related to asbestos are a common clinical problem and a major health concern worldwide. Extensive research has identified many important pathogenic mechanisms; however, the precise molecular mechanisms involved, and the generated genomic damage that lead to the development of these diseases, are not completely understood. The modes of action that underlie this type of disease seem to differ depending on the type of fiber, lung clearance, and genetics. This evidences the need to increase our knowledge about these effects on human health. This review focuses on the characteristics of asbestos and the cellular and genomic damage generated in humans via exposure.",

author = "Diana Ospina and Villegas, {Victoria Eugenia} and Giovanni Rodr{\'i}guez-Leguizam{\'o}n and Milena Rond{\'o}n-Lagos",

note = "Funding Information: Graphic designer Elizabeth Cruz Tapias is acknowledged for the illustrations. The authors also thank MDPI English editing group for editing a draft of this manuscript. This research was funded by Corporaci{\'o}n Hospitalaria Juan Ciudad – Hospital Universitario Mayor – M{\'e}deri. Publisher Copyright: {\textcopyright} 2019 Zhang et al. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

year = "2019",

doi = "10.2147/CMAR.S205723",

language = "English (US)",

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pages = "4997--5012",

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AU - Ospina, Diana

AU - Villegas, Victoria Eugenia

AU - Rodríguez-Leguizamón, Giovanni

AU - Rondón-Lagos, Milena

N1 - Funding Information: Graphic designer Elizabeth Cruz Tapias is acknowledged for the illustrations. The authors also thank MDPI English editing group for editing a draft of this manuscript. This research was funded by Corporación Hospitalaria Juan Ciudad – Hospital Universitario Mayor – Méderi. Publisher Copyright: © 2019 Zhang et al. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019

Y1 - 2019

N2 - Asbestos is one of the most important occupational carcinogens. Currently, about 125 million people worldwide are exposed to asbestos in the workplace. According to global estimates, at least 107,000 people die each year from lung cancer, mesothelioma, and asbestosis as a result of occupational exposure to asbestos. The high pathogenicity of this material is currently known, being associated with the development of pulmonary diseases, of which lung cancer is the main cause of death due to exposure to this mineral. Pulmonary diseases related to asbestos are a common clinical problem and a major health concern worldwide. Extensive research has identified many important pathogenic mechanisms; however, the precise molecular mechanisms involved, and the generated genomic damage that lead to the development of these diseases, are not completely understood. The modes of action that underlie this type of disease seem to differ depending on the type of fiber, lung clearance, and genetics. This evidences the need to increase our knowledge about these effects on human health. This review focuses on the characteristics of asbestos and the cellular and genomic damage generated in humans via exposure.

AB - Asbestos is one of the most important occupational carcinogens. Currently, about 125 million people worldwide are exposed to asbestos in the workplace. According to global estimates, at least 107,000 people die each year from lung cancer, mesothelioma, and asbestosis as a result of occupational exposure to asbestos. The high pathogenicity of this material is currently known, being associated with the development of pulmonary diseases, of which lung cancer is the main cause of death due to exposure to this mineral. Pulmonary diseases related to asbestos are a common clinical problem and a major health concern worldwide. Extensive research has identified many important pathogenic mechanisms; however, the precise molecular mechanisms involved, and the generated genomic damage that lead to the development of these diseases, are not completely understood. The modes of action that underlie this type of disease seem to differ depending on the type of fiber, lung clearance, and genetics. This evidences the need to increase our knowledge about these effects on human health. This review focuses on the characteristics of asbestos and the cellular and genomic damage generated in humans via exposure.

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Analyzing biological and molecular characteristics and genomic damage induced by exposure to asbestos

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