An antibody profile of systemic lupus erythematosus detected by antigen microarray

Ittai Fattal, Noam Shental, Dror Mevorach, Juan Manuel Anaya, Avi Livneh, Pnina Langevitz, Gisele Zandman-Goddard, Rachel Pauzner, Miriam Lerner, Miri Blank, Maria Eugenia Hincapie, Uzi Gafter, Yaakov Naparstek, Yehuda Shoenfeld, Eytan Domany, Irun R. Cohen

Resultado de la investigación: Contribución a RevistaArtículo

49 Citas (Scopus)

Resumen

Patients with systemic lupus erythematosus (SLE) produce antibodies to many different self-antigens. Here, we investigated antibodies in SLE sera using an antigen microarray containing many hundreds of antigens, mostly self-antigens. The aim was to detect sets of antibody reactivities characteristic of SLE patients in each of various clinical states - SLE patients with acute lupus nephritis, SLE patients in renal remission, and SLE patients who had never had renal involvement. The analysis produced two novel findings: (i) an SLE antibody profile persists independently of disease activity and despite long-term clinical remission, and (ii) this SLE antibody profile includes increases in four specific immunoglobulin G (IgG) reactivities to double-stranded DNA (dsDNA), single-stranded DNA (ssDNA), Epstein-Barr virus (EBV) and hyaluronic acid; the profile also includes decreases in specific IgM reactivities to myeloperoxidase (MPO), CD99, collagen III, insulin-like growth factor binding protein 1 (IGFBP1) and cardiolipin. The reactivities together showed high sensitivity (> 93%) and high specificity for SLE (> 88%). A healthy control subject who had the SLE antibody profile was later found to develop clinical SLE. The present study did not detect antibody reactivities that differentiated among the various subgroups of SLE subjects with statistical significance. Thus, SLE is characterized by an enduring antibody profile irrespective of clinical state. The association of SLE with decreased IgM natural autoantibodies suggests that these autoantibodies might enhance resistance to SLE. © 2010 Blackwell Publishing Ltd.
Idioma originalEnglish (US)
Páginas (desde-hasta)337-343
Número de páginas7
PublicaciónImmunology
DOI
EstadoPublished - jul 1 2010

Huella dactilar

Systemic Lupus Erythematosus
Antigens
Antibodies
Autoantigens
Autoantibodies
Immunoglobulin M
Kidney
Insulin-Like Growth Factor Binding Protein 1
Lupus Nephritis
Cardiolipins
Hyaluronic Acid
Human Herpesvirus 4
Peroxidase
Healthy Volunteers
Collagen
Immunoglobulin G

Citar esto

Fattal, I., Shental, N., Mevorach, D., Anaya, J. M., Livneh, A., Langevitz, P., ... Cohen, I. R. (2010). An antibody profile of systemic lupus erythematosus detected by antigen microarray. Immunology, 337-343. https://doi.org/10.1111/j.1365-2567.2010.03245.x
Fattal, Ittai ; Shental, Noam ; Mevorach, Dror ; Anaya, Juan Manuel ; Livneh, Avi ; Langevitz, Pnina ; Zandman-Goddard, Gisele ; Pauzner, Rachel ; Lerner, Miriam ; Blank, Miri ; Hincapie, Maria Eugenia ; Gafter, Uzi ; Naparstek, Yaakov ; Shoenfeld, Yehuda ; Domany, Eytan ; Cohen, Irun R. / An antibody profile of systemic lupus erythematosus detected by antigen microarray. En: Immunology. 2010 ; pp. 337-343.
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title = "An antibody profile of systemic lupus erythematosus detected by antigen microarray",
abstract = "Patients with systemic lupus erythematosus (SLE) produce antibodies to many different self-antigens. Here, we investigated antibodies in SLE sera using an antigen microarray containing many hundreds of antigens, mostly self-antigens. The aim was to detect sets of antibody reactivities characteristic of SLE patients in each of various clinical states - SLE patients with acute lupus nephritis, SLE patients in renal remission, and SLE patients who had never had renal involvement. The analysis produced two novel findings: (i) an SLE antibody profile persists independently of disease activity and despite long-term clinical remission, and (ii) this SLE antibody profile includes increases in four specific immunoglobulin G (IgG) reactivities to double-stranded DNA (dsDNA), single-stranded DNA (ssDNA), Epstein-Barr virus (EBV) and hyaluronic acid; the profile also includes decreases in specific IgM reactivities to myeloperoxidase (MPO), CD99, collagen III, insulin-like growth factor binding protein 1 (IGFBP1) and cardiolipin. The reactivities together showed high sensitivity (> 93{\%}) and high specificity for SLE (> 88{\%}). A healthy control subject who had the SLE antibody profile was later found to develop clinical SLE. The present study did not detect antibody reactivities that differentiated among the various subgroups of SLE subjects with statistical significance. Thus, SLE is characterized by an enduring antibody profile irrespective of clinical state. The association of SLE with decreased IgM natural autoantibodies suggests that these autoantibodies might enhance resistance to SLE. {\circledC} 2010 Blackwell Publishing Ltd.",
author = "Ittai Fattal and Noam Shental and Dror Mevorach and Anaya, {Juan Manuel} and Avi Livneh and Pnina Langevitz and Gisele Zandman-Goddard and Rachel Pauzner and Miriam Lerner and Miri Blank and Hincapie, {Maria Eugenia} and Uzi Gafter and Yaakov Naparstek and Yehuda Shoenfeld and Eytan Domany and Cohen, {Irun R.}",
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Fattal, I, Shental, N, Mevorach, D, Anaya, JM, Livneh, A, Langevitz, P, Zandman-Goddard, G, Pauzner, R, Lerner, M, Blank, M, Hincapie, ME, Gafter, U, Naparstek, Y, Shoenfeld, Y, Domany, E & Cohen, IR 2010, 'An antibody profile of systemic lupus erythematosus detected by antigen microarray', Immunology, pp. 337-343. https://doi.org/10.1111/j.1365-2567.2010.03245.x

An antibody profile of systemic lupus erythematosus detected by antigen microarray. / Fattal, Ittai; Shental, Noam; Mevorach, Dror; Anaya, Juan Manuel; Livneh, Avi; Langevitz, Pnina; Zandman-Goddard, Gisele; Pauzner, Rachel; Lerner, Miriam; Blank, Miri; Hincapie, Maria Eugenia; Gafter, Uzi; Naparstek, Yaakov; Shoenfeld, Yehuda; Domany, Eytan; Cohen, Irun R.

En: Immunology, 01.07.2010, p. 337-343.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - An antibody profile of systemic lupus erythematosus detected by antigen microarray

AU - Fattal, Ittai

AU - Shental, Noam

AU - Mevorach, Dror

AU - Anaya, Juan Manuel

AU - Livneh, Avi

AU - Langevitz, Pnina

AU - Zandman-Goddard, Gisele

AU - Pauzner, Rachel

AU - Lerner, Miriam

AU - Blank, Miri

AU - Hincapie, Maria Eugenia

AU - Gafter, Uzi

AU - Naparstek, Yaakov

AU - Shoenfeld, Yehuda

AU - Domany, Eytan

AU - Cohen, Irun R.

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Patients with systemic lupus erythematosus (SLE) produce antibodies to many different self-antigens. Here, we investigated antibodies in SLE sera using an antigen microarray containing many hundreds of antigens, mostly self-antigens. The aim was to detect sets of antibody reactivities characteristic of SLE patients in each of various clinical states - SLE patients with acute lupus nephritis, SLE patients in renal remission, and SLE patients who had never had renal involvement. The analysis produced two novel findings: (i) an SLE antibody profile persists independently of disease activity and despite long-term clinical remission, and (ii) this SLE antibody profile includes increases in four specific immunoglobulin G (IgG) reactivities to double-stranded DNA (dsDNA), single-stranded DNA (ssDNA), Epstein-Barr virus (EBV) and hyaluronic acid; the profile also includes decreases in specific IgM reactivities to myeloperoxidase (MPO), CD99, collagen III, insulin-like growth factor binding protein 1 (IGFBP1) and cardiolipin. The reactivities together showed high sensitivity (> 93%) and high specificity for SLE (> 88%). A healthy control subject who had the SLE antibody profile was later found to develop clinical SLE. The present study did not detect antibody reactivities that differentiated among the various subgroups of SLE subjects with statistical significance. Thus, SLE is characterized by an enduring antibody profile irrespective of clinical state. The association of SLE with decreased IgM natural autoantibodies suggests that these autoantibodies might enhance resistance to SLE. © 2010 Blackwell Publishing Ltd.

AB - Patients with systemic lupus erythematosus (SLE) produce antibodies to many different self-antigens. Here, we investigated antibodies in SLE sera using an antigen microarray containing many hundreds of antigens, mostly self-antigens. The aim was to detect sets of antibody reactivities characteristic of SLE patients in each of various clinical states - SLE patients with acute lupus nephritis, SLE patients in renal remission, and SLE patients who had never had renal involvement. The analysis produced two novel findings: (i) an SLE antibody profile persists independently of disease activity and despite long-term clinical remission, and (ii) this SLE antibody profile includes increases in four specific immunoglobulin G (IgG) reactivities to double-stranded DNA (dsDNA), single-stranded DNA (ssDNA), Epstein-Barr virus (EBV) and hyaluronic acid; the profile also includes decreases in specific IgM reactivities to myeloperoxidase (MPO), CD99, collagen III, insulin-like growth factor binding protein 1 (IGFBP1) and cardiolipin. The reactivities together showed high sensitivity (> 93%) and high specificity for SLE (> 88%). A healthy control subject who had the SLE antibody profile was later found to develop clinical SLE. The present study did not detect antibody reactivities that differentiated among the various subgroups of SLE subjects with statistical significance. Thus, SLE is characterized by an enduring antibody profile irrespective of clinical state. The association of SLE with decreased IgM natural autoantibodies suggests that these autoantibodies might enhance resistance to SLE. © 2010 Blackwell Publishing Ltd.

U2 - 10.1111/j.1365-2567.2010.03245.x

DO - 10.1111/j.1365-2567.2010.03245.x

M3 - Article

SP - 337

EP - 343

JO - Immunology

JF - Immunology

SN - 0019-2805

ER -