TY - JOUR
T1 - ADHD Endophenotypes in Caribbean Families
AU - Cervantes-Henríquez, M. L.
AU - Acosta-López, J. E.
AU - Martínez-Banfi, M. L.
AU - Vélez, J. I.
AU - Mejía-Segura, E.
AU - Lozano-Gutiérrez, S. G.
AU - Sánchez-Rojas, M.
AU - Zurbarán, M. A.
AU - Zurek, E. E.
AU - Arcos-Burgos, M.
AU - Pineda, D. A.
AU - Puentes-Rozo, P. J.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Objective: The aim of this study is to contrast the genetics of neuropsychological tasks in individuals from nuclear families clustering ADHD in a Caribbean community. Method: We recruited and clinically characterized 408 individuals using an extensive battery of neuropsychological tasks. The genetic variance underpinning these tasks was estimated by heritability. A predictive framework for ADHD diagnosis was derived using these tasks. Results: We found that individuals with ADHD differed from controls in tasks of mental control, visuospatial ability, visuoverbal memory, phonological and verbal fluency, verbal and semantic fluency, cognitive flexibility, and cognitive ability. Among them, tasks of mental control, visuoverbal memory, phonological fluency, semantic verbal fluency, and intelligence had a significant heritability. A predictive model of ADHD diagnosis using these endophenotypes yields remarkable classification rate, sensitivity, specificity, and precision values (above 80%). Conclusion: We have dissected new cognitive endophenotypes in ADHD that can be suitable to assess the neurobiological and genetic basis of ADHD.
AB - Objective: The aim of this study is to contrast the genetics of neuropsychological tasks in individuals from nuclear families clustering ADHD in a Caribbean community. Method: We recruited and clinically characterized 408 individuals using an extensive battery of neuropsychological tasks. The genetic variance underpinning these tasks was estimated by heritability. A predictive framework for ADHD diagnosis was derived using these tasks. Results: We found that individuals with ADHD differed from controls in tasks of mental control, visuospatial ability, visuoverbal memory, phonological and verbal fluency, verbal and semantic fluency, cognitive flexibility, and cognitive ability. Among them, tasks of mental control, visuoverbal memory, phonological fluency, semantic verbal fluency, and intelligence had a significant heritability. A predictive model of ADHD diagnosis using these endophenotypes yields remarkable classification rate, sensitivity, specificity, and precision values (above 80%). Conclusion: We have dissected new cognitive endophenotypes in ADHD that can be suitable to assess the neurobiological and genetic basis of ADHD.
UR - http://www.scopus.com/inward/record.url?scp=85044936738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044936738&partnerID=8YFLogxK
U2 - 10.1177/1087054718763741
DO - 10.1177/1087054718763741
M3 - Article
C2 - 29589797
AN - SCOPUS:85044936738
SN - 1087-0547
VL - 24
SP - 2100
EP - 2114
JO - Journal of Attention Disorders
JF - Journal of Attention Disorders
IS - 14
ER -