Acute kidney injury in severely injured patients admitted to the intensive care unit

Alberto F. García, Ramiro Manzano-Nunez, Juan G. Bayona, Maria P. Naranjo, Dary Neicce Villa, Manuel Moreno, Sebastian Ossa, Juan M. Martinez, Nathalia Martinez, Juan C. Puyana

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Background
Our objective was to identify possible associations between clinical and laboratory variables and the risk of developing acute kidney injury (AKI) in severely injured patients admitted to the intensive care unit (ICU) for whom creatine kinase (CK) levels were available.

Methods
For this retrospective observational study, we analyzed adult trauma patients admitted to the ICU from 2011 to 2015 at Fundación Valle del Lili (FVL) University Hospital. Our primary outcome was the incidence of AKI. Multivariate regression analysis was used to assess risk factors for this outcome.

Results
A total of 315 patients were included. The trauma mechanisms were blunt (n = 130), penetrating (n = 66) and blast (n = 44) trauma. The median (interquartile range, IQR) of injury severity score (ISS) was 21 (16–29). AKI developed in 75 patients (23.8%). Multivariate regression analysis revealed that the thoracic abbreviated injury scale (AIS) value (median (IQR) in the AKI group: 3 (0–4)), Acute Physiology and Chronic Health Evaluation (APACHE II) score (median (IQR) in the AKI group: 18 (10–27)), CK greater than 5000 U/L, lactic acid concentration at admission, and dobutamine administration were independently associated with AKI.
Idioma originalInglés estadounidense
Número de artículo47
Número de páginas6
PublicaciónMilitary Medical Research
Volumen7
N.º1
DOI
EstadoPublicada - oct 9 2020
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Medicina (todo)

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