A signature of renal stress resistance induced by short-Term dietary restriction, fasting, and protein restriction

F. Jongbloed, T. C. Saat, M. Verweij, C. Payan-Gomez, J. H J Hoeijmakers, S. Van Den Engel, C. T. Van Oostrom, G. Ambagtsheer, S. Imholz, J. L A Pennings, H. Van Steeg, J. N M Ijzermans, M. E T Dollé, R. W F De Bruin

Resultado de la investigación: Contribución a la publicaciónArtículo

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Resumen

© The Author(s) 2017.During kidney transplantation, ischemia-reperfusion injury (IRI) induces oxidative stress. Short-Term preoperative 30% dietary restriction (DR) and 3-day fasting protect against renal IRI. We investigated the contribution of macronutrients to this protection on both phenotypical and transcriptional levels. Male C57BL/6 mice were fed control food ad libitum, underwent two weeks of 30%DR, 3-day fasting, or received a protein-, carbohydrate-or fat-free diet for various periods of time. After completion of each diet, renal gene expression was investigated using microarrays. After induction of renal IRI by clamping the renal pedicles, animals were monitored seven days postoperatively for signs of IRI. In addition to 3-day fasting and two weeks 30%DR, three days of a protein-free diet protected against renal IRI as well, whereas the other diets did not. Gene expression patterns significantly overlapped between all diets except the fat-free diet. Detailed meta-Analysis showed involvement of nuclear receptor signaling via transcription factors, including FOXO3, HNF4A and HMGA1. In conclusion, three days of a protein-free diet is sufficient to induce protection against renal IRI similar to 3-day fasting and two weeks of 30%DR. The elucidated network of common protective pathways and transcription factors further improves our mechanistic insight into the increased stress resistance induced by short-Term DR.
IdiomaEnglish (US)
PublicaciónScientific Reports
DOI
EstadoPublished - ene 19 2017

Huella dactilar

Reperfusion Injury
Fasting
Kidney
Protein-Restricted Diet
Fat-Restricted Diet
Proteins
Diet
Transcription Factors
Gene Expression
Cytoplasmic and Nuclear Receptors
Inbred C57BL Mouse
Constriction
Kidney Transplantation
Meta-Analysis
Oxidative Stress
Carbohydrates
Food

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Jongbloed, F., Saat, T. C., Verweij, M., Payan-Gomez, C., Hoeijmakers, J. H. J., Van Den Engel, S., ... De Bruin, R. W. F. (2017). A signature of renal stress resistance induced by short-Term dietary restriction, fasting, and protein restriction. Scientific Reports. DOI: 10.1038/srep40901
Jongbloed, F. ; Saat, T. C. ; Verweij, M. ; Payan-Gomez, C. ; Hoeijmakers, J. H J ; Van Den Engel, S. ; Van Oostrom, C. T. ; Ambagtsheer, G. ; Imholz, S. ; Pennings, J. L A ; Van Steeg, H. ; Ijzermans, J. N M ; Dollé, M. E T ; De Bruin, R. W F. / A signature of renal stress resistance induced by short-Term dietary restriction, fasting, and protein restriction. En: Scientific Reports. 2017
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title = "A signature of renal stress resistance induced by short-Term dietary restriction, fasting, and protein restriction",
abstract = "{\circledC} The Author(s) 2017.During kidney transplantation, ischemia-reperfusion injury (IRI) induces oxidative stress. Short-Term preoperative 30{\%} dietary restriction (DR) and 3-day fasting protect against renal IRI. We investigated the contribution of macronutrients to this protection on both phenotypical and transcriptional levels. Male C57BL/6 mice were fed control food ad libitum, underwent two weeks of 30{\%}DR, 3-day fasting, or received a protein-, carbohydrate-or fat-free diet for various periods of time. After completion of each diet, renal gene expression was investigated using microarrays. After induction of renal IRI by clamping the renal pedicles, animals were monitored seven days postoperatively for signs of IRI. In addition to 3-day fasting and two weeks 30{\%}DR, three days of a protein-free diet protected against renal IRI as well, whereas the other diets did not. Gene expression patterns significantly overlapped between all diets except the fat-free diet. Detailed meta-Analysis showed involvement of nuclear receptor signaling via transcription factors, including FOXO3, HNF4A and HMGA1. In conclusion, three days of a protein-free diet is sufficient to induce protection against renal IRI similar to 3-day fasting and two weeks of 30{\%}DR. The elucidated network of common protective pathways and transcription factors further improves our mechanistic insight into the increased stress resistance induced by short-Term DR.",
author = "F. Jongbloed and Saat, {T. C.} and M. Verweij and C. Payan-Gomez and Hoeijmakers, {J. H J} and {Van Den Engel}, S. and {Van Oostrom}, {C. T.} and G. Ambagtsheer and S. Imholz and Pennings, {J. L A} and {Van Steeg}, H. and Ijzermans, {J. N M} and Doll{\'e}, {M. E T} and {De Bruin}, {R. W F}",
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month = "1",
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Jongbloed, F, Saat, TC, Verweij, M, Payan-Gomez, C, Hoeijmakers, JHJ, Van Den Engel, S, Van Oostrom, CT, Ambagtsheer, G, Imholz, S, Pennings, JLA, Van Steeg, H, Ijzermans, JNM, Dollé, MET & De Bruin, RWF 2017, 'A signature of renal stress resistance induced by short-Term dietary restriction, fasting, and protein restriction' Scientific Reports. DOI: 10.1038/srep40901

A signature of renal stress resistance induced by short-Term dietary restriction, fasting, and protein restriction. / Jongbloed, F.; Saat, T. C.; Verweij, M.; Payan-Gomez, C.; Hoeijmakers, J. H J; Van Den Engel, S.; Van Oostrom, C. T.; Ambagtsheer, G.; Imholz, S.; Pennings, J. L A; Van Steeg, H.; Ijzermans, J. N M; Dollé, M. E T; De Bruin, R. W F.

En: Scientific Reports, 19.01.2017.

Resultado de la investigación: Contribución a la publicaciónArtículo

TY - JOUR

T1 - A signature of renal stress resistance induced by short-Term dietary restriction, fasting, and protein restriction

AU - Jongbloed,F.

AU - Saat,T. C.

AU - Verweij,M.

AU - Payan-Gomez,C.

AU - Hoeijmakers,J. H J

AU - Van Den Engel,S.

AU - Van Oostrom,C. T.

AU - Ambagtsheer,G.

AU - Imholz,S.

AU - Pennings,J. L A

AU - Van Steeg,H.

AU - Ijzermans,J. N M

AU - Dollé,M. E T

AU - De Bruin,R. W F

PY - 2017/1/19

Y1 - 2017/1/19

N2 - © The Author(s) 2017.During kidney transplantation, ischemia-reperfusion injury (IRI) induces oxidative stress. Short-Term preoperative 30% dietary restriction (DR) and 3-day fasting protect against renal IRI. We investigated the contribution of macronutrients to this protection on both phenotypical and transcriptional levels. Male C57BL/6 mice were fed control food ad libitum, underwent two weeks of 30%DR, 3-day fasting, or received a protein-, carbohydrate-or fat-free diet for various periods of time. After completion of each diet, renal gene expression was investigated using microarrays. After induction of renal IRI by clamping the renal pedicles, animals were monitored seven days postoperatively for signs of IRI. In addition to 3-day fasting and two weeks 30%DR, three days of a protein-free diet protected against renal IRI as well, whereas the other diets did not. Gene expression patterns significantly overlapped between all diets except the fat-free diet. Detailed meta-Analysis showed involvement of nuclear receptor signaling via transcription factors, including FOXO3, HNF4A and HMGA1. In conclusion, three days of a protein-free diet is sufficient to induce protection against renal IRI similar to 3-day fasting and two weeks of 30%DR. The elucidated network of common protective pathways and transcription factors further improves our mechanistic insight into the increased stress resistance induced by short-Term DR.

AB - © The Author(s) 2017.During kidney transplantation, ischemia-reperfusion injury (IRI) induces oxidative stress. Short-Term preoperative 30% dietary restriction (DR) and 3-day fasting protect against renal IRI. We investigated the contribution of macronutrients to this protection on both phenotypical and transcriptional levels. Male C57BL/6 mice were fed control food ad libitum, underwent two weeks of 30%DR, 3-day fasting, or received a protein-, carbohydrate-or fat-free diet for various periods of time. After completion of each diet, renal gene expression was investigated using microarrays. After induction of renal IRI by clamping the renal pedicles, animals were monitored seven days postoperatively for signs of IRI. In addition to 3-day fasting and two weeks 30%DR, three days of a protein-free diet protected against renal IRI as well, whereas the other diets did not. Gene expression patterns significantly overlapped between all diets except the fat-free diet. Detailed meta-Analysis showed involvement of nuclear receptor signaling via transcription factors, including FOXO3, HNF4A and HMGA1. In conclusion, three days of a protein-free diet is sufficient to induce protection against renal IRI similar to 3-day fasting and two weeks of 30%DR. The elucidated network of common protective pathways and transcription factors further improves our mechanistic insight into the increased stress resistance induced by short-Term DR.

U2 - 10.1038/srep40901

DO - 10.1038/srep40901

M3 - Article

JO - Scientific Reports

T2 - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

ER -

Jongbloed F, Saat TC, Verweij M, Payan-Gomez C, Hoeijmakers JHJ, Van Den Engel S y otros. A signature of renal stress resistance induced by short-Term dietary restriction, fasting, and protein restriction. Scientific Reports. 2017 ene 19. Disponible desde, DOI: 10.1038/srep40901