A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis

Luis Miguel Gómez, Juan Manuel Anaya, José Ramón Vilchez, Jose Cadena, Rosa Hinojosa, Luciano Vélez, Miguel Angel Lopez-Nevot, Javier Martín

Resultado de la investigación: Contribución a RevistaArtículo

45 Citas (Scopus)

Resumen

iNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO production and disease outcome. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of two polymorphisms in the NOS2A gene on the risk of developing pulmonary TB in a Northwestern Colombian population, which is a moderately-high endemic area. One hundred and fourteen patients with TB and negative for human immunodeficiency virus, plus 304 healthy controls were examined for NOS2A CCTTT and TAAA polymorphisms. A total of 160 healthy controls mentioned before, underwent tuberculin skin test (TST). Analysis disclosed significant differences between patients and controls with NOS2A CCTTT polymorphism (P=0.0001, Pc=0.001, OR=0.4, and 95%CI=0.3-0.7) independent of TST status. When the NOS2A alleles were stratified into short (8-11) and long (12-16) repeats, significant differences with short repeats were observed between TB patients and all controls (P=0.005, OR=0.63, 95%CI=0.46-0.86). No individual association with NOS2A TAAA was detected. These results indicate that a polymorphism in the NOS2A gene influences the susceptibility to TB and suggest a role for NOS2A in the pathogenesis of mycobacterial infection. © 2007 Elsevier Ltd. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)288-294
Número de páginas7
PublicaciónTuberculosis
DOI
EstadoPublished - jul 1 2007

Huella dactilar

Nitric Oxide Synthase Type II
Tuberculin Test
Tuberculosis
Skin Tests
Nitric Oxide
Genes
Alleles
HIV
Lung
Infection
Population

Citar esto

Miguel Gómez, L., Anaya, J. M., Ramón Vilchez, J., Cadena, J., Hinojosa, R., Vélez, L., ... Martín, J. (2007). A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis. Tuberculosis, 288-294. https://doi.org/10.1016/j.tube.2007.03.002
Miguel Gómez, Luis ; Anaya, Juan Manuel ; Ramón Vilchez, José ; Cadena, Jose ; Hinojosa, Rosa ; Vélez, Luciano ; Angel Lopez-Nevot, Miguel ; Martín, Javier. / A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis. En: Tuberculosis. 2007 ; pp. 288-294.
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title = "A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis",
abstract = "iNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO production and disease outcome. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of two polymorphisms in the NOS2A gene on the risk of developing pulmonary TB in a Northwestern Colombian population, which is a moderately-high endemic area. One hundred and fourteen patients with TB and negative for human immunodeficiency virus, plus 304 healthy controls were examined for NOS2A CCTTT and TAAA polymorphisms. A total of 160 healthy controls mentioned before, underwent tuberculin skin test (TST). Analysis disclosed significant differences between patients and controls with NOS2A CCTTT polymorphism (P=0.0001, Pc=0.001, OR=0.4, and 95{\%}CI=0.3-0.7) independent of TST status. When the NOS2A alleles were stratified into short (8-11) and long (12-16) repeats, significant differences with short repeats were observed between TB patients and all controls (P=0.005, OR=0.63, 95{\%}CI=0.46-0.86). No individual association with NOS2A TAAA was detected. These results indicate that a polymorphism in the NOS2A gene influences the susceptibility to TB and suggest a role for NOS2A in the pathogenesis of mycobacterial infection. {\circledC} 2007 Elsevier Ltd. All rights reserved.",
author = "{Miguel G{\'o}mez}, Luis and Anaya, {Juan Manuel} and {Ram{\'o}n Vilchez}, Jos{\'e} and Jose Cadena and Rosa Hinojosa and Luciano V{\'e}lez and {Angel Lopez-Nevot}, Miguel and Javier Mart{\'i}n",
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Miguel Gómez, L, Anaya, JM, Ramón Vilchez, J, Cadena, J, Hinojosa, R, Vélez, L, Angel Lopez-Nevot, M & Martín, J 2007, 'A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis', Tuberculosis, pp. 288-294. https://doi.org/10.1016/j.tube.2007.03.002

A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis. / Miguel Gómez, Luis; Anaya, Juan Manuel; Ramón Vilchez, José; Cadena, Jose; Hinojosa, Rosa; Vélez, Luciano; Angel Lopez-Nevot, Miguel; Martín, Javier.

En: Tuberculosis, 01.07.2007, p. 288-294.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis

AU - Miguel Gómez, Luis

AU - Anaya, Juan Manuel

AU - Ramón Vilchez, José

AU - Cadena, Jose

AU - Hinojosa, Rosa

AU - Vélez, Luciano

AU - Angel Lopez-Nevot, Miguel

AU - Martín, Javier

PY - 2007/7/1

Y1 - 2007/7/1

N2 - iNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO production and disease outcome. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of two polymorphisms in the NOS2A gene on the risk of developing pulmonary TB in a Northwestern Colombian population, which is a moderately-high endemic area. One hundred and fourteen patients with TB and negative for human immunodeficiency virus, plus 304 healthy controls were examined for NOS2A CCTTT and TAAA polymorphisms. A total of 160 healthy controls mentioned before, underwent tuberculin skin test (TST). Analysis disclosed significant differences between patients and controls with NOS2A CCTTT polymorphism (P=0.0001, Pc=0.001, OR=0.4, and 95%CI=0.3-0.7) independent of TST status. When the NOS2A alleles were stratified into short (8-11) and long (12-16) repeats, significant differences with short repeats were observed between TB patients and all controls (P=0.005, OR=0.63, 95%CI=0.46-0.86). No individual association with NOS2A TAAA was detected. These results indicate that a polymorphism in the NOS2A gene influences the susceptibility to TB and suggest a role for NOS2A in the pathogenesis of mycobacterial infection. © 2007 Elsevier Ltd. All rights reserved.

AB - iNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO production and disease outcome. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of two polymorphisms in the NOS2A gene on the risk of developing pulmonary TB in a Northwestern Colombian population, which is a moderately-high endemic area. One hundred and fourteen patients with TB and negative for human immunodeficiency virus, plus 304 healthy controls were examined for NOS2A CCTTT and TAAA polymorphisms. A total of 160 healthy controls mentioned before, underwent tuberculin skin test (TST). Analysis disclosed significant differences between patients and controls with NOS2A CCTTT polymorphism (P=0.0001, Pc=0.001, OR=0.4, and 95%CI=0.3-0.7) independent of TST status. When the NOS2A alleles were stratified into short (8-11) and long (12-16) repeats, significant differences with short repeats were observed between TB patients and all controls (P=0.005, OR=0.63, 95%CI=0.46-0.86). No individual association with NOS2A TAAA was detected. These results indicate that a polymorphism in the NOS2A gene influences the susceptibility to TB and suggest a role for NOS2A in the pathogenesis of mycobacterial infection. © 2007 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.tube.2007.03.002

DO - 10.1016/j.tube.2007.03.002

M3 - Article

SP - 288

EP - 294

JO - Tuberculosis

JF - Tuberculosis

SN - 1472-9792

ER -