A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia

Victor Pordeus, Ori Barzilai, Yaniv Sherer, Ronir Raggio Luiz, Miri Blank, Nicola Bizzaro, Danilo Villalta, Juan Manuel Anaya, Yehuda Shoenfeld

Resultado de la investigación: Contribución a RevistaArtículo

20 Citas (Scopus)

Resumen

Background: Infectious agents are important in the pathogenesis of autoimmune disease since they are a major part of the environmental trigger of autoimmunity. A negative relationship between latitude and infectious disease species richness has been suggested. Objectives: To examine whether their prevalence differs in two latitudinally different populations. Methods: The prevalence of infections with Toxoplasma gondii, rubella virus, cytomegalovirus, Epstein-Barr virus and Treponema pallidum was compared between subjects from Italy and Colombia. Results: We found high titers of antibodies against four of five microorganisms tested, Toxoplasma gondii (50.8%), rubella virus (German measles) (75%), cytomegalovirus (86.3%), Epstein-Barr virus (83.3%) and Treponema pallidum (6.3%) in completely healthy individuals from a tropical country (Colombia) and a European country (Italy). Differences between two groups of volunteers were noted regarding two infectious agents. The prevalence of immunoglobulin G anti-rubella antibodies was significantly higher among Italian subjects (85% vs. 67.9%, P = 0.002), whereas antibodies against CMV were less prevalent among Italian as compared to Colombian subjects (77% vs. 92.9%, P <0.001). Conclusions: These differences might also result in a different tendency towards development of autoimmune diseases associated with these infectious agents in different populations.
Idioma originalEnglish (US)
Páginas (desde-hasta)65-68
Número de páginas4
PublicaciónIsrael Medical Association Journal
EstadoPublished - ene 1 2008

Huella dactilar

Colombia
Italy
Rubella virus
Treponema pallidum
Cytomegalovirus
Human Herpesvirus 4
Autoimmune Diseases
Antibodies
Rubella
Toxoplasmosis
Toxoplasma
Autoimmunity
Population
Communicable Diseases
Volunteers
Anti-Idiotypic Antibodies
Immunoglobulin G

Citar esto

Pordeus, V., Barzilai, O., Sherer, Y., Luiz, R. R., Blank, M., Bizzaro, N., ... Shoenfeld, Y. (2008). A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia. Israel Medical Association Journal, 65-68.
Pordeus, Victor ; Barzilai, Ori ; Sherer, Yaniv ; Luiz, Ronir Raggio ; Blank, Miri ; Bizzaro, Nicola ; Villalta, Danilo ; Anaya, Juan Manuel ; Shoenfeld, Yehuda. / A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia. En: Israel Medical Association Journal. 2008 ; pp. 65-68.
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title = "A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia",
abstract = "Background: Infectious agents are important in the pathogenesis of autoimmune disease since they are a major part of the environmental trigger of autoimmunity. A negative relationship between latitude and infectious disease species richness has been suggested. Objectives: To examine whether their prevalence differs in two latitudinally different populations. Methods: The prevalence of infections with Toxoplasma gondii, rubella virus, cytomegalovirus, Epstein-Barr virus and Treponema pallidum was compared between subjects from Italy and Colombia. Results: We found high titers of antibodies against four of five microorganisms tested, Toxoplasma gondii (50.8{\%}), rubella virus (German measles) (75{\%}), cytomegalovirus (86.3{\%}), Epstein-Barr virus (83.3{\%}) and Treponema pallidum (6.3{\%}) in completely healthy individuals from a tropical country (Colombia) and a European country (Italy). Differences between two groups of volunteers were noted regarding two infectious agents. The prevalence of immunoglobulin G anti-rubella antibodies was significantly higher among Italian subjects (85{\%} vs. 67.9{\%}, P = 0.002), whereas antibodies against CMV were less prevalent among Italian as compared to Colombian subjects (77{\%} vs. 92.9{\%}, P <0.001). Conclusions: These differences might also result in a different tendency towards development of autoimmune diseases associated with these infectious agents in different populations.",
author = "Victor Pordeus and Ori Barzilai and Yaniv Sherer and Luiz, {Ronir Raggio} and Miri Blank and Nicola Bizzaro and Danilo Villalta and Anaya, {Juan Manuel} and Yehuda Shoenfeld",
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Pordeus, V, Barzilai, O, Sherer, Y, Luiz, RR, Blank, M, Bizzaro, N, Villalta, D, Anaya, JM & Shoenfeld, Y 2008, 'A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia', Israel Medical Association Journal, pp. 65-68.

A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia. / Pordeus, Victor; Barzilai, Ori; Sherer, Yaniv; Luiz, Ronir Raggio; Blank, Miri; Bizzaro, Nicola; Villalta, Danilo; Anaya, Juan Manuel; Shoenfeld, Yehuda.

En: Israel Medical Association Journal, 01.01.2008, p. 65-68.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia

AU - Pordeus, Victor

AU - Barzilai, Ori

AU - Sherer, Yaniv

AU - Luiz, Ronir Raggio

AU - Blank, Miri

AU - Bizzaro, Nicola

AU - Villalta, Danilo

AU - Anaya, Juan Manuel

AU - Shoenfeld, Yehuda

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Background: Infectious agents are important in the pathogenesis of autoimmune disease since they are a major part of the environmental trigger of autoimmunity. A negative relationship between latitude and infectious disease species richness has been suggested. Objectives: To examine whether their prevalence differs in two latitudinally different populations. Methods: The prevalence of infections with Toxoplasma gondii, rubella virus, cytomegalovirus, Epstein-Barr virus and Treponema pallidum was compared between subjects from Italy and Colombia. Results: We found high titers of antibodies against four of five microorganisms tested, Toxoplasma gondii (50.8%), rubella virus (German measles) (75%), cytomegalovirus (86.3%), Epstein-Barr virus (83.3%) and Treponema pallidum (6.3%) in completely healthy individuals from a tropical country (Colombia) and a European country (Italy). Differences between two groups of volunteers were noted regarding two infectious agents. The prevalence of immunoglobulin G anti-rubella antibodies was significantly higher among Italian subjects (85% vs. 67.9%, P = 0.002), whereas antibodies against CMV were less prevalent among Italian as compared to Colombian subjects (77% vs. 92.9%, P <0.001). Conclusions: These differences might also result in a different tendency towards development of autoimmune diseases associated with these infectious agents in different populations.

AB - Background: Infectious agents are important in the pathogenesis of autoimmune disease since they are a major part of the environmental trigger of autoimmunity. A negative relationship between latitude and infectious disease species richness has been suggested. Objectives: To examine whether their prevalence differs in two latitudinally different populations. Methods: The prevalence of infections with Toxoplasma gondii, rubella virus, cytomegalovirus, Epstein-Barr virus and Treponema pallidum was compared between subjects from Italy and Colombia. Results: We found high titers of antibodies against four of five microorganisms tested, Toxoplasma gondii (50.8%), rubella virus (German measles) (75%), cytomegalovirus (86.3%), Epstein-Barr virus (83.3%) and Treponema pallidum (6.3%) in completely healthy individuals from a tropical country (Colombia) and a European country (Italy). Differences between two groups of volunteers were noted regarding two infectious agents. The prevalence of immunoglobulin G anti-rubella antibodies was significantly higher among Italian subjects (85% vs. 67.9%, P = 0.002), whereas antibodies against CMV were less prevalent among Italian as compared to Colombian subjects (77% vs. 92.9%, P <0.001). Conclusions: These differences might also result in a different tendency towards development of autoimmune diseases associated with these infectious agents in different populations.

M3 - Article

SP - 65

EP - 68

JO - Israel Medical Association Journal

JF - Israel Medical Association Journal

SN - 1565-1088

ER -

Pordeus V, Barzilai O, Sherer Y, Luiz RR, Blank M, Bizzaro N y otros. A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia. Israel Medical Association Journal. 2008 ene 1;65-68.