A latent genetic subtype of major depression identified by whole-exome genotyping data in a Mexican-American cohort

C. Q. Yu, M. Arcos-Burgos, Julio Licinio, Ma Li Wong

Resultado de la investigación: Contribución a RevistaArtículo

8 Citas (Scopus)

Resumen

Identifying data-driven subtypes of major depressive disorder (MDD) is an important topic of psychiatric research. Currently, MDD subtypes are based on clinically defined depression symptom patterns. Although a few data-driven attempts have been made to identify more homogenous subgroups within MDD, other studies have not focused on using human genetic data for MDD subtyping. Here we used a computational strategy to identify MDD subtypes based on single-nucleotide polymorphism genotyping data from MDD cases and controls using Hamming distance and cluster analysis. We examined a cohort of Mexican-American participants from Los Angeles, including MDD patients (n=203) and healthy controls (n=196). The results in cluster trees indicate that a significant latent subtype exists in the Mexican-American MDD group. The individuals in this hidden subtype have increased common genetic substrates related to major depression and they also have more anxiety and less middle insomnia, depersonalization and derealisation, and paranoid symptoms. Advances in this line of research to validate this strategy in other patient groups of different ethnicities will have the potential to eventually be translated to clinical practice, with the tantalising possibility that in the future it may be possible to refine MDD diagnosis based on genetic data.

Idioma originalEnglish (US)
Número de artículoe1134
PublicaciónTranslational Psychiatry
Volumen7
N.º5
DOI
EstadoPublished - may 16 2017
Publicado de forma externa

Huella dactilar

Exome
Major Depressive Disorder
Depression
Depersonalization
Los Angeles
Medical Genetics
Sleep Initiation and Maintenance Disorders
Research
Single Nucleotide Polymorphism
Cluster Analysis
Psychiatry
Anxiety

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Biological Psychiatry

Citar esto

Yu, C. Q. ; Arcos-Burgos, M. ; Licinio, Julio ; Wong, Ma Li. / A latent genetic subtype of major depression identified by whole-exome genotyping data in a Mexican-American cohort. En: Translational Psychiatry. 2017 ; Vol. 7, N.º 5.
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A latent genetic subtype of major depression identified by whole-exome genotyping data in a Mexican-American cohort. / Yu, C. Q.; Arcos-Burgos, M.; Licinio, Julio; Wong, Ma Li.

En: Translational Psychiatry, Vol. 7, N.º 5, e1134, 16.05.2017.

Resultado de la investigación: Contribución a RevistaArtículo

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