A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis

Livia Cristina Liporagi Lopes; Allan J. Guimarães; Mariana Duarte De Cerqueira; Beatriz L. Gómez; Joshua D. Nosanchuk

doi:10.1128/CVI.00033-10

A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis

Livia Cristina Liporagi Lopes
, Allan J. Guimarães
, Mariana Duarte De Cerqueira
, Beatriz L. Gómez
, Joshua D. Nosanchuk

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

17 Citas (Scopus)

Resumen

Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	1155-1158
Número de páginas	4
Publicación	Clinical and Vaccine Immunology
Volumen	17
N.º	7
DOI	https://doi.org/10.1128/CVI.00033-10
Estado	Publicada - jul. 2010
Publicado de forma externa	Sí

Áreas temáticas de ASJC Scopus

Inmulogía y alergología
Inmunología
Bioquímica clínica
Microbiología (médica)

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title = "A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis",

abstract = "Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.",

author = "Lopes, \{Livia Cristina Liporagi\} and Guimar{\~a}es, \{Allan J.\} and \{De Cerqueira\}, \{Mariana Duarte\} and G{\'o}mez, \{Beatriz L.\} and Nosanchuk, \{Joshua D.\}",

year = "2010",

month = jul,

doi = "10.1128/CVI.00033-10",

language = "English (US)",

volume = "17",

pages = "1155--1158",

journal = "Clinical and Vaccine Immunology",

issn = "1556-6811",

publisher = "American Society for Microbiology",

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}

A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis. / Lopes, Livia Cristina Liporagi; Guimarães, Allan J.; De Cerqueira, Mariana Duarte et al.
En: Clinical and Vaccine Immunology, Vol. 17, N.º 7, 07.2010, p. 1155-1158.

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

TY - JOUR

T1 - A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis

AU - Lopes, Livia Cristina Liporagi

AU - Guimarães, Allan J.

AU - De Cerqueira, Mariana Duarte

AU - Gómez, Beatriz L.

AU - Nosanchuk, Joshua D.

PY - 2010/7

Y1 - 2010/7

N2 - Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.

AB - Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.

UR - https://www.scopus.com/pages/publications/77954382075

UR - https://www.scopus.com/pages/publications/77954382075#tab=citedBy

U2 - 10.1128/CVI.00033-10

DO - 10.1128/CVI.00033-10

M3 - Research Article

C2 - 20484567

AN - SCOPUS:77954382075

SN - 1556-6811

VL - 17

SP - 1155

EP - 1158

JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

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ER -

A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis

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