Thalamo-cortical synchronization during sensory information processing in the vibrissal motor cortex in rats

Proyecto: Proyecto de Investigación

Detalles del proyecto

Descripción

Vibrissal sensorymotor system enables rodents to extract precise information about three-dimensional configurations in their proximal immediate environment. Whisking movements are generated by both extrinsic (retraction) and intrinsic (protraction) vibrissal muscles controlled by facial motoneurons. Motoneuronal activity is driven by primary motor cortex (vM1) both directly and through premotor structures participating in central pattern generators. Vibrissal movement instantly modifies sensory input, which, in turn, biases exploration focus as a function of animal's ongoing task and motivational state. Given its central role in whisking control, vM1 mustTo do so, it generates motor commands based on sensory input instant changes, which requires continuous interactions between vibrissal motor cortex (vM1) and somatosensory thalamic nuclei (posteromedial, POM; and, ventroposteromedial, VPM). Bipolar stimulating whisker pad electrodes and vM1 and POM or VPM recording electrodes will be implanted to anesthetized Wistar rats to evaluate such interactions. Single and paired whisker pad stimuli will be administered while cortical and thalamic field potentials were recorded. Following single whisker pad stimuli short-latency population spikes occurred simultaneously in vM1, POM, and VPM. Such spikes were followed by low frequency oscillations associated to long-lasting epochs of enhanced thalamo-cortical coherence. The aim of the present project will be evaluate the thalamo-cortical interaction in motor cortex after sensory stimulation.
Título cortoSincronización talamo cortical
EstadoFinalizado
Fecha de inicio / finalización efectiva12/3/1912/15/20