ZC3H12A (MCPIP1): Molecular characteristics and clinical implications

Ricardo A. Cifuentes, Paola Cruz-Tapias, Adriana Rojas-Villarraga, Juan Manuel Anaya

Research output: Contribution to journalLiterature review

9 Citations (Scopus)

Abstract

Background: ZC3H12A is a gene whose absence is related to autoimmune disorders and to other phenotypical alterations. Methods: A comprehensive review of the structure, molecular functions and regulation of ZC3H12A gene and its protein MCPIP1 is done in order to understand their clinical implications. Results: ZC3H12A, at 1p34.3, has 9860 bp, six exons and 61 described SNPs. Eleven are non-synonymous thus leading to changes in MCPIP1, the protein encoded by ZC3H12A. MCPIP1 is induced by MCP-1 and IL-1 whose signals are transduced through the NF-kβ and MAPkinase pathways. This protein acts as an RNAse by degrading chemokine transcripts such as IL-1 as well as its own mRNA and as a transcription factor by reducing the expression of other chemokines induced by NF-kβ such as MCP-1. It also up-regulates genes involved in several differentiation processes and apoptosis. Therefore, ZC3H12A is an equilibrium gatekeeper that not only regulates its own inducers but also controls the regulation by degrading its own mRNA. Conclusion: Understanding ZC3H12A gives a comprehensive panorama that promises to improve our understanding of processes in which this gene is involved including autoimmune, infectious and cardiovascular diseases. © 2010 Elsevier B.V.
Original languageEnglish (US)
Pages (from-to)1862-1868
Number of pages7
JournalClinica Chimica Acta
DOIs
StatePublished - Dec 14 2010

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Genes
Interleukin-1
Chemokines
Messenger RNA
Proteins
Molecular Structure
Molecular structure
Autoimmune Diseases
Single Nucleotide Polymorphism
Communicable Diseases
Exons
Transcription Factors
Cardiovascular Diseases
Up-Regulation
Apoptosis

Cite this

Cifuentes, R. A., Cruz-Tapias, P., Rojas-Villarraga, A., & Anaya, J. M. (2010). ZC3H12A (MCPIP1): Molecular characteristics and clinical implications. Clinica Chimica Acta, 1862-1868. https://doi.org/10.1016/j.cca.2010.08.033
Cifuentes, Ricardo A. ; Cruz-Tapias, Paola ; Rojas-Villarraga, Adriana ; Anaya, Juan Manuel. / ZC3H12A (MCPIP1): Molecular characteristics and clinical implications. In: Clinica Chimica Acta. 2010 ; pp. 1862-1868.
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Cifuentes, RA, Cruz-Tapias, P, Rojas-Villarraga, A & Anaya, JM 2010, 'ZC3H12A (MCPIP1): Molecular characteristics and clinical implications', Clinica Chimica Acta, pp. 1862-1868. https://doi.org/10.1016/j.cca.2010.08.033

ZC3H12A (MCPIP1): Molecular characteristics and clinical implications. / Cifuentes, Ricardo A.; Cruz-Tapias, Paola; Rojas-Villarraga, Adriana; Anaya, Juan Manuel.

In: Clinica Chimica Acta, 14.12.2010, p. 1862-1868.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - ZC3H12A (MCPIP1): Molecular characteristics and clinical implications

AU - Cifuentes, Ricardo A.

AU - Cruz-Tapias, Paola

AU - Rojas-Villarraga, Adriana

AU - Anaya, Juan Manuel

PY - 2010/12/14

Y1 - 2010/12/14

N2 - Background: ZC3H12A is a gene whose absence is related to autoimmune disorders and to other phenotypical alterations. Methods: A comprehensive review of the structure, molecular functions and regulation of ZC3H12A gene and its protein MCPIP1 is done in order to understand their clinical implications. Results: ZC3H12A, at 1p34.3, has 9860 bp, six exons and 61 described SNPs. Eleven are non-synonymous thus leading to changes in MCPIP1, the protein encoded by ZC3H12A. MCPIP1 is induced by MCP-1 and IL-1 whose signals are transduced through the NF-kβ and MAPkinase pathways. This protein acts as an RNAse by degrading chemokine transcripts such as IL-1 as well as its own mRNA and as a transcription factor by reducing the expression of other chemokines induced by NF-kβ such as MCP-1. It also up-regulates genes involved in several differentiation processes and apoptosis. Therefore, ZC3H12A is an equilibrium gatekeeper that not only regulates its own inducers but also controls the regulation by degrading its own mRNA. Conclusion: Understanding ZC3H12A gives a comprehensive panorama that promises to improve our understanding of processes in which this gene is involved including autoimmune, infectious and cardiovascular diseases. © 2010 Elsevier B.V.

AB - Background: ZC3H12A is a gene whose absence is related to autoimmune disorders and to other phenotypical alterations. Methods: A comprehensive review of the structure, molecular functions and regulation of ZC3H12A gene and its protein MCPIP1 is done in order to understand their clinical implications. Results: ZC3H12A, at 1p34.3, has 9860 bp, six exons and 61 described SNPs. Eleven are non-synonymous thus leading to changes in MCPIP1, the protein encoded by ZC3H12A. MCPIP1 is induced by MCP-1 and IL-1 whose signals are transduced through the NF-kβ and MAPkinase pathways. This protein acts as an RNAse by degrading chemokine transcripts such as IL-1 as well as its own mRNA and as a transcription factor by reducing the expression of other chemokines induced by NF-kβ such as MCP-1. It also up-regulates genes involved in several differentiation processes and apoptosis. Therefore, ZC3H12A is an equilibrium gatekeeper that not only regulates its own inducers but also controls the regulation by degrading its own mRNA. Conclusion: Understanding ZC3H12A gives a comprehensive panorama that promises to improve our understanding of processes in which this gene is involved including autoimmune, infectious and cardiovascular diseases. © 2010 Elsevier B.V.

U2 - 10.1016/j.cca.2010.08.033

DO - 10.1016/j.cca.2010.08.033

M3 - Literature review

SP - 1862

EP - 1868

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

ER -