What is known about the immune response induced by Plasmodium vivax malaria vaccine candidates?

Carolina López, Yoelis Yepes-Pérez, Natalia Hincapié-Escobar, Diana Díaz-Arévalo, Manuel A. Patarroyo

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Malaria caused by Plasmodium vivax continues being one of the most important infectious diseases around the world; P. vivax is the second most prevalent species and has the greatest geographic distribution. Developing an effective antimalarial vaccine is considered a relevant control strategy in the search for means of preventing the disease. Studying parasite-expressed proteins, which are essential in host cell invasion, has led to identifying the regions recognized by individuals who are naturally exposed to infection. Furthermore, immunogenicity studies have revealed that such regions can trigger a robust immune response that can inhibit sporozoite (hepatic stage) or merozoite (erythrocyte stage) invasion of a host cell and induce protection. This review provides a synthesis of the most important studies to date concerning the antigenicity and immunogenicity of both synthetic peptide and recombinant protein candidates for a vaccine against malaria produced by P. vivax.

Original languageEnglish (US)
Article number126
JournalFrontiers in Immunology
Volume8
Issue numberFEB
DOIs
StatePublished - Feb 13 2017

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Author Keywords

  • Concept

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