Valor de las pruebas inmunologicas en el diagnostico de la histoplasmosis meningea

N. Ordóñez; M. Arango; B. Gómez; A. M. Tobón; I. Gómez; L. Franco; M. I. Medina; E. Sánchez; E. Castañeda; A. Restrepo

Valor de las pruebas inmunologicas en el diagnostico de la histoplasmosis meningea

Translated title of the contribution: Value of immunological assays in the diagnosis of meningeal histoplasmosis

N. Ordóñez, M. Arango, B. Gómez, A. M. Tobón, I. Gómez, L. Franco, M. I. Medina, E. Sánchez, E. Castañeda, A. Restrepo

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Introduction. Between 1985 and 1995, 3,860 cerebrospinal fiuid (CSF) samples from patients with mycotic meningitis were analyzed. Methods. Direct examination, cultures, complement fixation (CF) and immunodiffusion (ID) with Histoplasma capsulatum were carried out. Results. Seventy four samples from 31 patients (three of them with AIDS) were reactive at the immunological assays. Cultures were positive in five patients. In 26 patients the clinical diagnosis together with positive CSF assays gave indirect evidence of meningeal histoplasmosis. ID ad CF reactivity were 93.5% and 100% respectively. For 23 patients who had simultaneous examination of blood and CSF the double positivity was 78.2%. Conclusions. Because of the direct isolation of Histoplasma capsulatum is a difficult one, the diagnosis of subacute or chronic meningeal histoplasmosis may be confirmed by indirect immunological assays.

Translated title of the contribution	Value of immunological assays in the diagnosis of meningeal histoplasmosis
Original language	Spanish
Pages (from-to)	1376-1380
Number of pages	5
Journal	Revista de Neurologia
Volume	25
Issue number	145
State	Published - Sep 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Clinical Neurology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Valor de las pruebas inmunologicas en el diagnostico de la histoplasmosis meningea",

abstract = "Introduction. Between 1985 and 1995, 3,860 cerebrospinal fiuid (CSF) samples from patients with mycotic meningitis were analyzed. Methods. Direct examination, cultures, complement fixation (CF) and immunodiffusion (ID) with Histoplasma capsulatum were carried out. Results. Seventy four samples from 31 patients (three of them with AIDS) were reactive at the immunological assays. Cultures were positive in five patients. In 26 patients the clinical diagnosis together with positive CSF assays gave indirect evidence of meningeal histoplasmosis. ID ad CF reactivity were 93.5% and 100% respectively. For 23 patients who had simultaneous examination of blood and CSF the double positivity was 78.2%. Conclusions. Because of the direct isolation of Histoplasma capsulatum is a difficult one, the diagnosis of subacute or chronic meningeal histoplasmosis may be confirmed by indirect immunological assays.",

author = "N. Ord{\'o}{\~n}ez and M. Arango and B. G{\'o}mez and Tob{\'o}n, {A. M.} and I. G{\'o}mez and L. Franco and Medina, {M. I.} and E. S{\'a}nchez and E. Casta{\~n}eda and A. Restrepo",

year = "1997",

month = sep,

language = "Espa{\~n}ol",

volume = "25",

pages = "1376--1380",

journal = "Revista de Neurologia",

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publisher = "Revista de Neurologia",

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TY - JOUR

T1 - Valor de las pruebas inmunologicas en el diagnostico de la histoplasmosis meningea

AU - Ordóñez, N.

AU - Arango, M.

AU - Gómez, B.

AU - Tobón, A. M.

AU - Gómez, I.

AU - Franco, L.

AU - Medina, M. I.

AU - Sánchez, E.

AU - Castañeda, E.

AU - Restrepo, A.

PY - 1997/9

Y1 - 1997/9

N2 - Introduction. Between 1985 and 1995, 3,860 cerebrospinal fiuid (CSF) samples from patients with mycotic meningitis were analyzed. Methods. Direct examination, cultures, complement fixation (CF) and immunodiffusion (ID) with Histoplasma capsulatum were carried out. Results. Seventy four samples from 31 patients (three of them with AIDS) were reactive at the immunological assays. Cultures were positive in five patients. In 26 patients the clinical diagnosis together with positive CSF assays gave indirect evidence of meningeal histoplasmosis. ID ad CF reactivity were 93.5% and 100% respectively. For 23 patients who had simultaneous examination of blood and CSF the double positivity was 78.2%. Conclusions. Because of the direct isolation of Histoplasma capsulatum is a difficult one, the diagnosis of subacute or chronic meningeal histoplasmosis may be confirmed by indirect immunological assays.

AB - Introduction. Between 1985 and 1995, 3,860 cerebrospinal fiuid (CSF) samples from patients with mycotic meningitis were analyzed. Methods. Direct examination, cultures, complement fixation (CF) and immunodiffusion (ID) with Histoplasma capsulatum were carried out. Results. Seventy four samples from 31 patients (three of them with AIDS) were reactive at the immunological assays. Cultures were positive in five patients. In 26 patients the clinical diagnosis together with positive CSF assays gave indirect evidence of meningeal histoplasmosis. ID ad CF reactivity were 93.5% and 100% respectively. For 23 patients who had simultaneous examination of blood and CSF the double positivity was 78.2%. Conclusions. Because of the direct isolation of Histoplasma capsulatum is a difficult one, the diagnosis of subacute or chronic meningeal histoplasmosis may be confirmed by indirect immunological assays.

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M3 - Artículo

C2 - 9377293

AN - SCOPUS:0030866806

SN - 0210-0010

VL - 25

SP - 1376

EP - 1380

JO - Revista de Neurologia

JF - Revista de Neurologia

IS - 145

ER -

Valor de las pruebas inmunologicas en el diagnostico de la histoplasmosis meningea

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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