Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy

Diego H. Caceres; Christina M. Scheel; Ángela M. Tob́on; Angela Ahlquist Cleveland; Ángela Restrepo; Mary E. Brandt; Tom Chiller; Beatriz L. Gómez

doi:10.1128/CVI.00101-14

Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy

Diego H. Caceres, Christina M. Scheel, Ángela M. Tob́on, Angela Ahlquist Cleveland, Ángela Restrepo, Mary E. Brandt, Tom Chiller, Beatriz L. Gómez

School of Medicine and Health Sciences

Research output: Contribution to journal › Research Article › peer-review

42 Scopus citations

Abstract

We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy.

Original language	English (US)
Pages (from-to)	1364-1368
Number of pages	5
Journal	Clinical and Vaccine Immunology
Volume	21
Issue number	9
DOIs	https://doi.org/10.1128/CVI.00101-14
State	Published - Sep 2014

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Clinical Biochemistry
Microbiology (medical)

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10.1128/CVI.00101-14

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Caceres, D. H., Scheel, C. M., Tob́on, Á. M., Cleveland, A. A., Restrepo, Á., Brandt, M. E., Chiller, T., & Gómez, B. L. (2014). Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy. Clinical and Vaccine Immunology, 21(9), 1364-1368. https://doi.org/10.1128/CVI.00101-14

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title = "Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy",

abstract = "We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86\%, and the overall specificity was 94\%. The antigen test successfully monitored the response to therapy.",

author = "Caceres, \{Diego H.\} and Scheel, \{Christina M.\} and To{\'b}on, \{{\'A}ngela M.\} and Cleveland, \{Angela Ahlquist\} and {\'A}ngela Restrepo and Brandt, \{Mary E.\} and Tom Chiller and G{\'o}mez, \{Beatriz L.\}",

year = "2014",

month = sep,

doi = "10.1128/CVI.00101-14",

language = "English (US)",

volume = "21",

pages = "1364--1368",

journal = "Clinical and Vaccine Immunology",

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}

Caceres, DH, Scheel, CM, Tob́on, ÁM, Cleveland, AA, Restrepo, Á, Brandt, ME, Chiller, T & Gómez, BL 2014, 'Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy', Clinical and Vaccine Immunology, vol. 21, no. 9, pp. 1364-1368. https://doi.org/10.1128/CVI.00101-14

Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy. / Caceres, Diego H.; Scheel, Christina M.; Tob́on, Ángela M. et al.
In: Clinical and Vaccine Immunology, Vol. 21, No. 9, 09.2014, p. 1364-1368.

Research output: Contribution to journal › Research Article › peer-review

TY - JOUR

T1 - Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy

AU - Caceres, Diego H.

AU - Scheel, Christina M.

AU - Tob́on, Ángela M.

AU - Cleveland, Angela Ahlquist

AU - Restrepo, Ángela

AU - Brandt, Mary E.

AU - Chiller, Tom

AU - Gómez, Beatriz L.

PY - 2014/9

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AB - We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy.

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IS - 9

ER -

Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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