Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy

Diego H. Caceres; Christina M. Scheel; Ángela M. Tob́on; Angela Ahlquist Cleveland; Ángela Restrepo; Mary E. Brandt; Tom Chiller; Beatriz L. Gómez

doi:10.1128/CVI.00101-14

Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy

Diego H. Caceres
, Christina M. Scheel
, Ángela M. Tob́on
, Angela Ahlquist Cleveland
, Ángela Restrepo
, Mary E. Brandt
, Tom Chiller
, Beatriz L. Gómez

School of Medicine and Health Sciences

Research output: Contribution to Journal › Research Article › peer-review

43 Scopus citations

Abstract

We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy.

Original language	English (US)
Pages (from-to)	1364-1368
Number of pages	5
Journal	Clinical and Vaccine Immunology
Volume	21
Issue number	9
DOIs	https://doi.org/10.1128/CVI.00101-14
State	Published - Sep 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Clinical Biochemistry
Microbiology (medical)

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10.1128/CVI.00101-14

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Caceres, D. H., Scheel, C. M., Tob́on, Á. M., Cleveland, A. A., Restrepo, Á., Brandt, M. E., Chiller, T., & Gómez, B. L. (2014). Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy. Clinical and Vaccine Immunology, 21(9), 1364-1368. https://doi.org/10.1128/CVI.00101-14

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title = "Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy",

abstract = "We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86\%, and the overall specificity was 94\%. The antigen test successfully monitored the response to therapy.",

author = "Caceres, \{Diego H.\} and Scheel, \{Christina M.\} and To{\'b}on, \{{\'A}ngela M.\} and Cleveland, \{Angela Ahlquist\} and {\'A}ngela Restrepo and Brandt, \{Mary E.\} and Tom Chiller and G{\'o}mez, \{Beatriz L.\}",

year = "2014",

month = sep,

doi = "10.1128/CVI.00101-14",

language = "English (US)",

volume = "21",

pages = "1364--1368",

number = "9",

}

Caceres, DH, Scheel, CM, Tob́on, ÁM, Cleveland, AA, Restrepo, Á, Brandt, ME, Chiller, T & Gómez, BL 2014, 'Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy', Clinical and Vaccine Immunology, vol. 21, no. 9, pp. 1364-1368. https://doi.org/10.1128/CVI.00101-14

Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy. / Caceres, Diego H.; Scheel, Christina M.; Tob́on, Ángela M. et al.
In: Clinical and Vaccine Immunology, Vol. 21, No. 9, 09.2014, p. 1364-1368.

Research output: Contribution to Journal › Research Article › peer-review

TY - JOUR

T1 - Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy

AU - Caceres, Diego H.

AU - Scheel, Christina M.

AU - Tob́on, Ángela M.

AU - Cleveland, Angela Ahlquist

AU - Restrepo, Ángela

AU - Brandt, Mary E.

AU - Chiller, Tom

AU - Gómez, Beatriz L.

PY - 2014/9

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N2 - We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy.

AB - We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy.

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U2 - 10.1128/CVI.00101-14

DO - 10.1128/CVI.00101-14

M3 - Research Article

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AN - SCOPUS:84940299660

SN - 1556-6811

VL - 21

SP - 1364

EP - 1368

JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

IS - 9

ER -

Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy

Abstract

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All Science Journal Classification (ASJC) codes

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