Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy

Diego H. Caceres, Christina M. Scheel, Ángela M. Tob́on, Angela Ahlquist Cleveland, Ángela Restrepo, Mary E. Brandt, Tom Chiller, Beatriz L. Gómez

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy.

Original languageEnglish (US)
Pages (from-to)1364-1368
Number of pages5
JournalClinical and Vaccine Immunology
Volume21
Issue number9
DOIs
StatePublished - Sep 2014

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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