Validación de la entrevista diagnóstica para estudios genéticos (DIGS) en Colombia.

Translated title of the contribution: Validation of the Diagnostic Interview for Genetic Studies (DIGS) in Colombia

Carlos Alberto Palacio, Jenny García, María Patricia Arbeláez, Ricardo Sánchez, Beatriz Aguirre, Isabel Cristina Garcés, Gabriel Jaime Montoya, Juliana Gómez, Angela Agudelo, Carlos Alberto López, Jorge Julián Calle, Carlos Alberto Cardeño, Juan Fernando Cano, María Cecilia López, Patricia Montoya, Claudia Patricia Herrera, Natalia González, Alejandro González, Gabriel Bedoya, Andrés RuizJorge Ospina

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


An interview tool, Diagnostic Interview for Genetic Studies (DIGS 3.0), was translated into Spanish for application in studies of psychiatric disorders in Colombia. Two Spanish translations of the original English version of DIGS were prepared and back-translated into English. A review committee verified the linguistic and cultural equivalence of the translations. The evaluator and test-retest reliability were assessed calculating Cohen's kappa for samples of 65 and 91 patients respectively. DIGS proved valid in both appearance and content. The confidence interval (C.I.) was excellent for schizophrenia (kappa = 0.81, C.I. 95% = 0.68-0.93), bipolar disorder (kappa = 0.87, C.I. 95% = 0.75-0.99), major depressive disorder (kappa = 0.86, C.I. 95% = 0.70-1.00), and for a normal diagnosis (kappa = 0.65, C.I. 95% = 0.41-0.89); it was good for other psychiatric diagnosis (kappa = 0.65, C.I. 95% = 0.41-0.89) and poor for schizoaffective disorder (kappa = 0.37, C.I. 95% = -0.02-0.76). Test-retest reliability was excellent for all diagnoses (kappa > 0.8), except for "other psychiatric diagnoses" (kappa = 0.64, C.I. 95% = 0.31-0.96). The Spanish translation of the DIGS was comprehensible, with face and content validity, and good test-retest and evaluator reliability. This translation will be a useful tool for genetic studies of psychiatric disorders in Latin America, particularly where schizophrenia and affective disorders are involved.

Translated title of the contributionValidation of the Diagnostic Interview for Genetic Studies (DIGS) in Colombia
Original languageSpanish
Pages (from-to)56-62
Number of pages7
JournalBiomédica : revista del Instituto Nacional de Salud
Issue number1
StatePublished - Mar 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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