TY - JOUR
T1 - Uveitis characteristics and multiple sclerosis phenotype of patients with multiple sclerosis-associated uveitis
T2 - A systematic review and meta-analysis
AU - Saboya-Galindo, Paola
AU - Mejía-Salgado, Germán
AU - Cifuentes-González, Carlos
AU - Rodríguez-Rodríguez, Camilo Andrés
AU - Boada-Robayo, Laura
AU - Méndez-Marulanda, Rafael
AU - Varela, Joan Sebastián
AU - Riveros-Sierra, Laura
AU - Gaviria-Carrillo, Mariana
AU - de-La-Torre, Alejandra
N1 - Publisher Copyright:
© 2024 Saboya-Galindo et al.
PY - 2024/10
Y1 - 2024/10
N2 - Purpose To summarize and meta-analyze uveitis characteristics and multiple sclerosis (MS) phenotype of patients with multiple sclerosis-associated uveitis (MSAU) within a systematic review and meta-analysis. Methods A comprehensive literature search was performed on January 25, 2023, utilizing PubMed, Embase, and Virtual Health Library (VHL) databases. We included studies involving patients with MSAU, such as case series with over 10 patients, cross-sectional, case-control, and cohort studies. Quality and risk of bias were assessed using CLARITY tools and validated metrics like the Hoy et al. and Hassan Murad et al. tools. The pooled analysis focused on 1) uveitis characteristics, 2) ocular complications, 3) MS phenotype, and 3) administered treatments for uveitis and MS. Gender-based subgroup analysis was conducted across continents; heterogeneity was measured using the I2 statistic. Statistical analysis was performed using R software version 4.3.1. The study was registered in PROSPERO with CRD42023453495 number.
AB - Purpose To summarize and meta-analyze uveitis characteristics and multiple sclerosis (MS) phenotype of patients with multiple sclerosis-associated uveitis (MSAU) within a systematic review and meta-analysis. Methods A comprehensive literature search was performed on January 25, 2023, utilizing PubMed, Embase, and Virtual Health Library (VHL) databases. We included studies involving patients with MSAU, such as case series with over 10 patients, cross-sectional, case-control, and cohort studies. Quality and risk of bias were assessed using CLARITY tools and validated metrics like the Hoy et al. and Hassan Murad et al. tools. The pooled analysis focused on 1) uveitis characteristics, 2) ocular complications, 3) MS phenotype, and 3) administered treatments for uveitis and MS. Gender-based subgroup analysis was conducted across continents; heterogeneity was measured using the I2 statistic. Statistical analysis was performed using R software version 4.3.1. The study was registered in PROSPERO with CRD42023453495 number.
UR - http://www.scopus.com/inward/record.url?scp=85207738950&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85207738950&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0307455
DO - 10.1371/journal.pone.0307455
M3 - Research Article
C2 - 39453915
AN - SCOPUS:85207738950
SN - 1932-6203
VL - 19
JO - PLOS ONE
JF - PLOS ONE
IS - 10 October
M1 - e0307455
ER -