Uveitis and nail psoriasis in a patient without articular involvement: a case report

Juan Sebastián Pineda-Sierra, Luisa Fernanda Peña-Pulgar, Carlos Cifuentes-González, William Rojas-Carabali, Alejandra de-la-Torre

Research output: Contribution to journalResearch Articlepeer-review


Background: This study aimed to report a case of bilateral anterior non-granulomatous chronic non-infectious uveitis associated with isolated nail psoriasis without articular involvement. Case presentation: A 55-year-old man with a history of open-angle glaucoma was referred to our uveitis and ocular immunology center with intraocular inflammation concordant with chronic non-infectious bilateral anterior non-granulomatous uveitis. At presentation, he had moderate inflammation in the anterior chamber bilaterally and lesions characteristic of nail psoriasis. Nail psoriasis was later confirmed by nail ultrasonography performed by a radiologist who specialized in psoriasis. Appropriate clinical and paraclinical assessments were conducted, ruling out all other possible causes of uveitis. The patient required dual systemic immunomodulatory therapy with methotrexate and adalimumab, topical anti-inflammatory drugs (steroidal and non-steroidal), and anti-glaucoma therapy to achieve satisfactory inflammatory and ocular pressure control. Discussion and conclusions: This is the first report of non-infectious uveitis associated with nail compromise in a patient without other manifestations of psoriasis. Despite reports on the relationship between psoriatic disease and uveitis, there is insufficient information on clinical phenotypes associated with uveitis that could lead to later diagnosis and treatment of associated intraocular inflammation. Clinicians should be aware of all subtypes of psoriasis that increases a risk of developing uveitis in these patients.

Translated title of the contributionUveítis y psoriasis ungueal en un paciente sin compromiso articular: reporte de un caso
Original languageEnglish (US)
Article number384
Pages (from-to)1-5
Number of pages5
JournalBMC Ophthalmology
Issue number384
StatePublished - Sep 24 2022

All Science Journal Classification (ASJC) codes

  • Ophthalmology


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