Bilateral Herpes Simplex Uveitis: Review of the Literature and Own Reports‏

Alejandra de-la-Torre, Juanita Valdes-Camacho, C. Stephen Foster

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Herpes simplex-associated uveitis is usually considered a unilateral eye disease, and rarely included in the differential diagnosis whenever there is bilateral involvement. We report three cases of bilateral herpetic anterior uveitis. Methods: We evaluated three patients who presented with clinical manifestations of bilateral uveitis suggestive of viral origin. Results: We found intraocular hypertension, cells in the anterior chamber, paralytic mydriasis, iris atrophy with transillumination defects, and variable anterior vitreous cellularity. According to the clinical findings, supported with herpes-specific antibody titers and aqueous humor PCR results in two of them, they were diagnosed with bilateral anterior herpetic uveitis. Conclusions: Our patients were initially misdiagnosed as having non-infectious uveitis and were treated with immunomodulatory medications, which could have favored the extension of infection bilaterally. Although uncommon, bilateral herpetic uveitis should always be considered in the differential diagnoses, when patients present with hypertensive uveitis in both eyes.
Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalOcular Immunology and Inflammation
DOIs
StatePublished - Mar 20 2016

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Herpes Simplex
Uveitis
Anterior Uveitis
Differential Diagnosis
Transillumination
Mydriasis
Eye Diseases
Aqueous Humor
Anterior Chamber
Iris
Diagnostic Errors
Atrophy
Hypertension
Polymerase Chain Reaction
Antibodies
Infection

Cite this

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title = "Bilateral Herpes Simplex Uveitis: Review of the Literature and Own Reports‏",
abstract = "Purpose: Herpes simplex-associated uveitis is usually considered a unilateral eye disease, and rarely included in the differential diagnosis whenever there is bilateral involvement. We report three cases of bilateral herpetic anterior uveitis. Methods: We evaluated three patients who presented with clinical manifestations of bilateral uveitis suggestive of viral origin. Results: We found intraocular hypertension, cells in the anterior chamber, paralytic mydriasis, iris atrophy with transillumination defects, and variable anterior vitreous cellularity. According to the clinical findings, supported with herpes-specific antibody titers and aqueous humor PCR results in two of them, they were diagnosed with bilateral anterior herpetic uveitis. Conclusions: Our patients were initially misdiagnosed as having non-infectious uveitis and were treated with immunomodulatory medications, which could have favored the extension of infection bilaterally. Although uncommon, bilateral herpetic uveitis should always be considered in the differential diagnoses, when patients present with hypertensive uveitis in both eyes.",
author = "Alejandra de-la-Torre and Juanita Valdes-Camacho and Foster, {C. Stephen}",
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Bilateral Herpes Simplex Uveitis: Review of the Literature and Own Reports‏. / de-la-Torre, Alejandra; Valdes-Camacho, Juanita; Foster, C. Stephen.

In: Ocular Immunology and Inflammation, 20.03.2016, p. 1-6.

Research output: Contribution to journalArticle

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T1 - Bilateral Herpes Simplex Uveitis: Review of the Literature and Own Reports‏

AU - de-la-Torre, Alejandra

AU - Valdes-Camacho, Juanita

AU - Foster, C. Stephen

PY - 2016/3/20

Y1 - 2016/3/20

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AB - Purpose: Herpes simplex-associated uveitis is usually considered a unilateral eye disease, and rarely included in the differential diagnosis whenever there is bilateral involvement. We report three cases of bilateral herpetic anterior uveitis. Methods: We evaluated three patients who presented with clinical manifestations of bilateral uveitis suggestive of viral origin. Results: We found intraocular hypertension, cells in the anterior chamber, paralytic mydriasis, iris atrophy with transillumination defects, and variable anterior vitreous cellularity. According to the clinical findings, supported with herpes-specific antibody titers and aqueous humor PCR results in two of them, they were diagnosed with bilateral anterior herpetic uveitis. Conclusions: Our patients were initially misdiagnosed as having non-infectious uveitis and were treated with immunomodulatory medications, which could have favored the extension of infection bilaterally. Although uncommon, bilateral herpetic uveitis should always be considered in the differential diagnoses, when patients present with hypertensive uveitis in both eyes.

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