Use of subcutaneous ivermectin in hyperinfection syndrome by Strongyloides stercoralis. A case report / Uso de ivermectina subcutánea en síndrome de hiperinfección por Strongyloides stercoralis. Reporte un caso

Translated title of the contribution: Use of subcutaneous ivermectin in hyperinfection syndrome by Strongyloides stercoralis. A case report

Diana Carolina Hennessey, Oscar Andrés Ballesteros, Diego Javier Merchán, Freddy Orlando Guevara, Diego Fernando Severiche

Research output: Contribution to journalArticlepeer-review

Abstract

Strongyloidiasis is a disease caused by the nematode Strongyloides stercoralis that is endemic in rural regions in tropical and subtropical countries. Immunosuppressed patients have an increased risk of infection by this parasitic and are at risk of developing a hyperinfection syndrome which carries a higher risk of death. However, in Colombia and the world there is no parenteral presentation of ivermectin for the use in humans, which is an important problem in patients who have compromised enteral absorption, as in the case of patients with intestinal obstructions. We present the first case of hyperinfection syndrome by Strongyloides stercoralis in Colombia treated with subcutaneous ivermectin in order to encourage pharmacokinetic and pharmacodynamic studies to establish this route of administration in the future as an alternative to those patients who have a high risk of therapeutic failure with the oral route.

Translated title of the contributionUse of subcutaneous ivermectin in hyperinfection syndrome by Strongyloides stercoralis. A case report
Original languageEnglish
Article number6098
JournalBiomedica
Volume40
Issue number2
StatePublished - Jun 15 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Concepts

  • Concept
  • Injections, subcutaneous
  • Intestinal obstruction
  • immunosuppression
  • Ivermectin
  • Strongyloidiasis/drug therapy

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