TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus

John Castiblanco; Diana Cristina Varela; Natalia Castaño-Rodríguez; Adriana Rojas-Villarraga; María Eugenia Hincapié; Juan Manuel Anaya

doi:10.1016/j.meegid.2008.03.001

TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus

John Castiblanco
, Diana Cristina Varela
, Natalia Castaño-Rodríguez
, Adriana Rojas-Villarraga
, María Eugenia Hincapié
, Juan Manuel Anaya

Research output: Contribution to Journal › Research Article › peer-review

87 Scopus citations

Abstract

Background and aim: The involvement of Toll-like receptor (TLR)-mediated pathways in infectious and autoimmunity has been suggested. The MyD88 adaptor-like (Mal) protein, also known as the TIR domain-containing adaptor protein (TIRAP), is implicated in the TLR2- and TLR4-mediated MyD88-dependent signaling pathway. The aim of this study was to investigate the influence of the functional TIRAP (MAL) S180L polymorphism on tuberculosis (TB) and four autoimmune diseases namely: rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1D). Methods: This was a case-control and family based association study in which 1325 individuals from a well-defined Colombian population were involved. TIRAP (MAL) S180L genotyping was done by using a polymerase chain reaction-restriction fragment length polymorphism technique and by direct sequencing. Results: Leu180 allele was found to be a protective factor against developing TB (odd ratio (OR): 0.53, 95% confidence interval (CI): 0.29-0.97) and SLE (OR: 0.29, 95% CI: 0.14-0.61) while no significant influence on RA, pSS and T1D was observed. Conclusion: These results support the influence of TIRAP (MAL) S180L polymorphism on TB and indicate that TB and SLE might share a common immunogenetic pathway in the innate immune response.

Original language	English (US)
Pages (from-to)	541-544
Number of pages	4
Journal	Infection, Genetics and Evolution
Volume	8
Issue number	5
DOIs	https://doi.org/10.1016/j.meegid.2008.03.001
State	Published - Sep 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Microbiology
Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics
Microbiology (medical)
Infectious Diseases

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10.1016/j.meegid.2008.03.001

Cite this

@article{edb1dd0676a04bcb8d11feb1222dd69b,

title = "TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus",

abstract = "Background and aim: The involvement of Toll-like receptor (TLR)-mediated pathways in infectious and autoimmunity has been suggested. The MyD88 adaptor-like (Mal) protein, also known as the TIR domain-containing adaptor protein (TIRAP), is implicated in the TLR2- and TLR4-mediated MyD88-dependent signaling pathway. The aim of this study was to investigate the influence of the functional TIRAP (MAL) S180L polymorphism on tuberculosis (TB) and four autoimmune diseases namely: rheumatoid arthritis (RA), primary Sj{\"o}gren's syndrome (pSS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1D). Methods: This was a case-control and family based association study in which 1325 individuals from a well-defined Colombian population were involved. TIRAP (MAL) S180L genotyping was done by using a polymerase chain reaction-restriction fragment length polymorphism technique and by direct sequencing. Results: Leu180 allele was found to be a protective factor against developing TB (odd ratio (OR): 0.53, 95\% confidence interval (CI): 0.29-0.97) and SLE (OR: 0.29, 95\% CI: 0.14-0.61) while no significant influence on RA, pSS and T1D was observed. Conclusion: These results support the influence of TIRAP (MAL) S180L polymorphism on TB and indicate that TB and SLE might share a common immunogenetic pathway in the innate immune response.",

author = "John Castiblanco and Varela, \{Diana Cristina\} and Natalia Casta{\~n}o-Rodr{\'i}guez and Adriana Rojas-Villarraga and Hincapi{\'e}, \{Mar{\'i}a Eugenia\} and Anaya, \{Juan Manuel\}",

note = "Funding Information: We thank all patients and participants in this study and to Juan G. McEwen for his support. This study was granted by the “Comit{\'e} para el Desarrollo de la Investigaci{\'o}n” of the Universidad de Antioquia (Sostenibilidad 2007–2008), Medellin, Colombia, and the Rosario University, Bogot{\'a}, Colombia. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2008",

month = sep,

doi = "10.1016/j.meegid.2008.03.001",

language = "English (US)",

volume = "8",

pages = "541--544",

journal = "Infection, Genetics and Evolution",

issn = "1567-1348",

publisher = "Elsevier BV",

number = "5",

}

TY - JOUR

T1 - TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus

AU - Castiblanco, John

AU - Varela, Diana Cristina

AU - Castaño-Rodríguez, Natalia

AU - Rojas-Villarraga, Adriana

AU - Hincapié, María Eugenia

AU - Anaya, Juan Manuel

N1 - Funding Information: We thank all patients and participants in this study and to Juan G. McEwen for his support. This study was granted by the “Comité para el Desarrollo de la Investigación” of the Universidad de Antioquia (Sostenibilidad 2007–2008), Medellin, Colombia, and the Rosario University, Bogotá, Colombia. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2008/9

Y1 - 2008/9

N2 - Background and aim: The involvement of Toll-like receptor (TLR)-mediated pathways in infectious and autoimmunity has been suggested. The MyD88 adaptor-like (Mal) protein, also known as the TIR domain-containing adaptor protein (TIRAP), is implicated in the TLR2- and TLR4-mediated MyD88-dependent signaling pathway. The aim of this study was to investigate the influence of the functional TIRAP (MAL) S180L polymorphism on tuberculosis (TB) and four autoimmune diseases namely: rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1D). Methods: This was a case-control and family based association study in which 1325 individuals from a well-defined Colombian population were involved. TIRAP (MAL) S180L genotyping was done by using a polymerase chain reaction-restriction fragment length polymorphism technique and by direct sequencing. Results: Leu180 allele was found to be a protective factor against developing TB (odd ratio (OR): 0.53, 95% confidence interval (CI): 0.29-0.97) and SLE (OR: 0.29, 95% CI: 0.14-0.61) while no significant influence on RA, pSS and T1D was observed. Conclusion: These results support the influence of TIRAP (MAL) S180L polymorphism on TB and indicate that TB and SLE might share a common immunogenetic pathway in the innate immune response.

AB - Background and aim: The involvement of Toll-like receptor (TLR)-mediated pathways in infectious and autoimmunity has been suggested. The MyD88 adaptor-like (Mal) protein, also known as the TIR domain-containing adaptor protein (TIRAP), is implicated in the TLR2- and TLR4-mediated MyD88-dependent signaling pathway. The aim of this study was to investigate the influence of the functional TIRAP (MAL) S180L polymorphism on tuberculosis (TB) and four autoimmune diseases namely: rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1D). Methods: This was a case-control and family based association study in which 1325 individuals from a well-defined Colombian population were involved. TIRAP (MAL) S180L genotyping was done by using a polymerase chain reaction-restriction fragment length polymorphism technique and by direct sequencing. Results: Leu180 allele was found to be a protective factor against developing TB (odd ratio (OR): 0.53, 95% confidence interval (CI): 0.29-0.97) and SLE (OR: 0.29, 95% CI: 0.14-0.61) while no significant influence on RA, pSS and T1D was observed. Conclusion: These results support the influence of TIRAP (MAL) S180L polymorphism on TB and indicate that TB and SLE might share a common immunogenetic pathway in the innate immune response.

UR - https://www.scopus.com/pages/publications/46749097334

UR - https://www.scopus.com/pages/publications/46749097334#tab=citedBy

U2 - 10.1016/j.meegid.2008.03.001

DO - 10.1016/j.meegid.2008.03.001

M3 - Research Article

C2 - 18417424

AN - SCOPUS:46749097334

SN - 1567-1348

VL - 8

SP - 541

EP - 544

JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

IS - 5

ER -

TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus

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