Púrpura trombocitopénica trombótica en un paciente con infección por vih

Translated title of the contribution: Thrombotic thrombocytopenic purpura, in a hiv-infected patient. Case report

Juan Camilo Motta, Camilo Rodríguez, Antonia Pino Marín, Edgar Barrera

Research output: Contribution to journalArticlepeer-review

Abstract

Hematological manifestations for human immunodeficiency virus (HIV) infection are frequent and diverse due to its ability to affect almost all cell lines. Among these, thrombotic thrombocytopenic purpura (TTP) is one of the thrombotic microangiopathies syndromes, characterized by the presence of thrombocytopenia and microangiopathic hemolytic anemia with impaired renal function. Nowadays, the relationship between these two entities is rare given the current highly active antiretroviral therapy (HAART). We report the case of a 28-year-old patient, who presented with fever associated with gingival bleeding, generalized mucocutaneous pallor and progressive weakness. Routine investigations showed anemia and severe thrombocytopenia, schistocytes and micro spherocytes in peripheral blood smear. Required blood transfusion, with decreased ADAMTS 13 enzyme activity (6.8%). With these findings,TTP was diagnosed as the initial manifestation of the HIV infection. The patient received management with five sessions of plasmapheresis and HAART with subsequent improvement.

Translated title of the contributionThrombotic thrombocytopenic purpura, in a hiv-infected patient. Case report
Original languageSpanish
Pages (from-to)108-113
Number of pages6
JournalRevista Chilena de Infectologia
Volume38
Issue number1
DOIs
StatePublished - 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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