Abstract
TO THE EDITOR: According to the Fick’s law of diffusion, the
flux of a molecule is proportional to its concentration
gradient. During exercise, this gradient for muscle oxygen
apparently decreases because intramuscular and interstitial
values become similar. Hence, how it is possible to explain
that, in this condition, the O2 flow is doubled. To answer this
paradox, Clanton (1) offers one elegant model focusing on
the role of the myoglobin as sensor and controller of the
mitochondrial reticular network. While this presents a fine
mechanism from a valid biochemical approach, this model
assumes constancy in the diffusion coefficient, which minimizes the role of other physical factors and results in an
incomplete picture of this phenomenon.
flux of a molecule is proportional to its concentration
gradient. During exercise, this gradient for muscle oxygen
apparently decreases because intramuscular and interstitial
values become similar. Hence, how it is possible to explain
that, in this condition, the O2 flow is doubled. To answer this
paradox, Clanton (1) offers one elegant model focusing on
the role of the myoglobin as sensor and controller of the
mitochondrial reticular network. While this presents a fine
mechanism from a valid biochemical approach, this model
assumes constancy in the diffusion coefficient, which minimizes the role of other physical factors and results in an
incomplete picture of this phenomenon.
| Translated title of the contribution | THE IMPORTANCE OF DIFFUSION COEFFICIENT AND TEMPERATURE IN MUSCLE O2 |
|---|---|
| Original language | English |
| Pages (from-to) | 794-794 |
| Number of pages | 1 |
| Journal | Journal of Applied Physiology |
| Volume | 126 |
| DOIs |
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| State | Published - Mar 25 2019 |