TY - JOUR
T1 - The impact of HIV-1 within-host evolution on transmission dynamics
AU - Theys, Kristof
AU - Libin, Pieter
AU - Pineda-Peña, Andrea Clemencia
AU - Nowé, Ann
AU - Vandamme, Anne Mieke
AU - Abecasis, Ana B.
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2018/2
Y1 - 2018/2
N2 - The adaptive potential of HIV-1 is a vital mechanism to evade host immune responses and antiviral treatment. However, high evolutionary rates during persistent infection can impair transmission efficiency and alter disease progression in the new host, resulting in a delicate trade-off between within-host virulence and between-host infectiousness. This trade-off is visible in the disparity in evolutionary rates at within-host and between-host levels, and preferential transmission of ancestral donor viruses. Understanding the impact of within-host evolution for epidemiological studies is essential for the design of preventive and therapeutic measures. Herein, we review recent theoretical and experimental work that generated new insights into the complex link between within-host evolution and between-host fitness, revealing temporal and selective processes underlying the structure and dynamics of HIV-1 transmission.
AB - The adaptive potential of HIV-1 is a vital mechanism to evade host immune responses and antiviral treatment. However, high evolutionary rates during persistent infection can impair transmission efficiency and alter disease progression in the new host, resulting in a delicate trade-off between within-host virulence and between-host infectiousness. This trade-off is visible in the disparity in evolutionary rates at within-host and between-host levels, and preferential transmission of ancestral donor viruses. Understanding the impact of within-host evolution for epidemiological studies is essential for the design of preventive and therapeutic measures. Herein, we review recent theoretical and experimental work that generated new insights into the complex link between within-host evolution and between-host fitness, revealing temporal and selective processes underlying the structure and dynamics of HIV-1 transmission.
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U2 - 10.1016/j.coviro.2017.12.001
DO - 10.1016/j.coviro.2017.12.001
M3 - Review article
C2 - 29275182
AN - SCOPUS:85038847406
SN - 1879-6257
VL - 28
SP - 92
EP - 101
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -
