TY - JOUR
T1 - The high immunogenicity induced by modified sporozoites' malarial peptides depends on their phi (ϕ) and psi (ψ) angles
AU - Patarroyo, Manuel Elkin
AU - Bermudez Quintero, Adriana Janneth
AU - Alba, Martha Patricia
PY - 2012/12/7
Y1 - 2012/12/7
N2 - The importance of CSP- and STARP-derived ϕ and ψ dihedral angles in mHABP structure was analysed by (1)H NMR in the search for molecules which can be included as components of a first-line-of-defence Plasmodium falciparum sporozoite multi-epitope vaccine against the most lethal form of human malaria. Most of the aforementioned dihedral angles were left-hand-like polyproline type II (PPII(L)) structures whilst others had right-hand-like α-helix (α(R)), thus allowing mHABPS to fit better into MHCII molecules and thereby form an appropriate pMHCII complex and also establish the H-bonds which stabilise such complex and by this means induce an appropriate immune response. This information has great implications for vaccine development, malaria being one of them
AB - The importance of CSP- and STARP-derived ϕ and ψ dihedral angles in mHABP structure was analysed by (1)H NMR in the search for molecules which can be included as components of a first-line-of-defence Plasmodium falciparum sporozoite multi-epitope vaccine against the most lethal form of human malaria. Most of the aforementioned dihedral angles were left-hand-like polyproline type II (PPII(L)) structures whilst others had right-hand-like α-helix (α(R)), thus allowing mHABPS to fit better into MHCII molecules and thereby form an appropriate pMHCII complex and also establish the H-bonds which stabilise such complex and by this means induce an appropriate immune response. This information has great implications for vaccine development, malaria being one of them
UR - http://www.sciencedirect.com/science/article/pii/S0006291X12020803?via%3Dihub
U2 - 10.1016/j.bbrc.2012.10.088
DO - 10.1016/j.bbrc.2012.10.088
M3 - Article
SN - 0006-291X
VL - 429
SP - 81
EP - 86
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1-2
ER -
