The eukaryotic genome, its reads, and the unfinished assembly

José Fernando Muñoz, Juan Esteban Gallo, Elizabeth Misas, Juan Guillermo McEwen, Oliver Keatinge Clay

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

In recent years, readily affordable short read sequences provided by next-generation sequencing (NGS) have become longer and more accurate. This has led to a jump in interest in the utility of NGS-only approaches for exploring eukaryotic genomes. The concept of a static, 'finished' genome assembly, which still appears to be a faraway goal for many eukaryotes, is yielding to new paradigms. We here motivate an object-view concept where the raw reads are the main, fixed object, and assemblies with their annotations take a role of dynamically changing and modifiable views of that object.

Original languageEnglish (US)
Pages (from-to)2090-2093
Number of pages4
JournalFEBS Letters
Volume587
Issue number14
DOIs
StatePublished - Jul 11 2013

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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