The autoimmune ecology

Juan Manuel Anaya, Carolina Ramirez-Santana, Maria A. Alzate, Nicolas Molano-Gonzalez, Adriana Rojas-Villarraga

Research output: Contribution to journalLiterature review

36 Citations (Scopus)

Abstract

© 2016 Anaya, Ramirez-Santana, Alzate, Molano-Gonzalez and Rojas-Villarraga.Autoimmune diseases (ADs) represent a heterogeneous group of disorders that affect specific target organs or multiple organ systems. These conditions share common immunopathogenic mechanisms (i.e., the autoimmune tautology), which explain the clinical similarities they have among them as well as their familial clustering (i.e., coaggregation). As part of the autoimmune tautology, the influence of environmental exposure on the risk of developing ADs is paramount (i.e., the autoimmune ecology). In fact, environment, more than genetics, shapes immune system. Autoimmune ecology is akin to exposome, that is all the exposures - internal and external - across the lifespan, interacting with hereditary factors (both genetics and epigenetics) to favor or protect against autoimmunity and its outcomes. Herein, we provide an overview of the autoimmune ecology, focusing on the immune response to environmental agents in general, and microbiota, cigarette smoking, alcohol and coffee consumption, socioeconomic status (SES), gender and sex hormones, vitamin D, organic solvents, and vaccines in particular. Inclusion of the autoimmune ecology in disease etiology and health will improve the way personalized medicine is currently conceived and applied.
Original languageEnglish (US)
JournalFrontiers in Immunology
DOIs
StatePublished - Apr 26 2016

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Ecology
Autoimmune Diseases
Precision Medicine
Microbiota
Coffee
Environmental Exposure
Gonadal Steroid Hormones
Autoimmunity
Epigenomics
Social Class
Vitamin D
Alcohol Drinking
Cluster Analysis
Immune System
Vaccines
Smoking
Health

Cite this

Anaya, J. M., Ramirez-Santana, C., Alzate, M. A., Molano-Gonzalez, N., & Rojas-Villarraga, A. (2016). The autoimmune ecology. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2016.00139
Anaya, Juan Manuel ; Ramirez-Santana, Carolina ; Alzate, Maria A. ; Molano-Gonzalez, Nicolas ; Rojas-Villarraga, Adriana. / The autoimmune ecology. In: Frontiers in Immunology. 2016.
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Anaya, JM, Ramirez-Santana, C, Alzate, MA, Molano-Gonzalez, N & Rojas-Villarraga, A 2016, 'The autoimmune ecology', Frontiers in Immunology. https://doi.org/10.3389/fimmu.2016.00139

The autoimmune ecology. / Anaya, Juan Manuel; Ramirez-Santana, Carolina; Alzate, Maria A.; Molano-Gonzalez, Nicolas; Rojas-Villarraga, Adriana.

In: Frontiers in Immunology, 26.04.2016.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - The autoimmune ecology

AU - Anaya, Juan Manuel

AU - Ramirez-Santana, Carolina

AU - Alzate, Maria A.

AU - Molano-Gonzalez, Nicolas

AU - Rojas-Villarraga, Adriana

PY - 2016/4/26

Y1 - 2016/4/26

N2 - © 2016 Anaya, Ramirez-Santana, Alzate, Molano-Gonzalez and Rojas-Villarraga.Autoimmune diseases (ADs) represent a heterogeneous group of disorders that affect specific target organs or multiple organ systems. These conditions share common immunopathogenic mechanisms (i.e., the autoimmune tautology), which explain the clinical similarities they have among them as well as their familial clustering (i.e., coaggregation). As part of the autoimmune tautology, the influence of environmental exposure on the risk of developing ADs is paramount (i.e., the autoimmune ecology). In fact, environment, more than genetics, shapes immune system. Autoimmune ecology is akin to exposome, that is all the exposures - internal and external - across the lifespan, interacting with hereditary factors (both genetics and epigenetics) to favor or protect against autoimmunity and its outcomes. Herein, we provide an overview of the autoimmune ecology, focusing on the immune response to environmental agents in general, and microbiota, cigarette smoking, alcohol and coffee consumption, socioeconomic status (SES), gender and sex hormones, vitamin D, organic solvents, and vaccines in particular. Inclusion of the autoimmune ecology in disease etiology and health will improve the way personalized medicine is currently conceived and applied.

AB - © 2016 Anaya, Ramirez-Santana, Alzate, Molano-Gonzalez and Rojas-Villarraga.Autoimmune diseases (ADs) represent a heterogeneous group of disorders that affect specific target organs or multiple organ systems. These conditions share common immunopathogenic mechanisms (i.e., the autoimmune tautology), which explain the clinical similarities they have among them as well as their familial clustering (i.e., coaggregation). As part of the autoimmune tautology, the influence of environmental exposure on the risk of developing ADs is paramount (i.e., the autoimmune ecology). In fact, environment, more than genetics, shapes immune system. Autoimmune ecology is akin to exposome, that is all the exposures - internal and external - across the lifespan, interacting with hereditary factors (both genetics and epigenetics) to favor or protect against autoimmunity and its outcomes. Herein, we provide an overview of the autoimmune ecology, focusing on the immune response to environmental agents in general, and microbiota, cigarette smoking, alcohol and coffee consumption, socioeconomic status (SES), gender and sex hormones, vitamin D, organic solvents, and vaccines in particular. Inclusion of the autoimmune ecology in disease etiology and health will improve the way personalized medicine is currently conceived and applied.

U2 - 10.3389/fimmu.2016.00139

DO - 10.3389/fimmu.2016.00139

M3 - Literature review

C2 - 27199979

JO - Frontiers in Immunology

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Anaya JM, Ramirez-Santana C, Alzate MA, Molano-Gonzalez N, Rojas-Villarraga A. The autoimmune ecology. Frontiers in Immunology. 2016 Apr 26. https://doi.org/10.3389/fimmu.2016.00139